Pcl/Chitosan Blended Nanofibrous Tubes Made by Dual Syringe Electrospinning

Hild, Martin; Rez, Mohammed Fayez Al; Aibibu, Dilbar; Toskas, Georgios; Cheng, Tai; Laourine, Ezzedine; Cherif, Chokri

doi:10.1515/aut-2015-0016

Cited by 9 publications

(5 citation statements)

References 22 publications

(27 reference statements)

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“…These findings agreed with other reported results. Hild et al 38 prepared PCL-CS membranes with diameters ranging from 200 to 400 nm, 38 while Van der Schueren et al 11 obtained smaller PCL-CS membranes (200 to 250 nm). 11 Considering poly(ε-caprolactone)-based membranes loaded with dexamethasone (5 to 20 wt.% concerning the whole polymer content), Martins et al 30 reported nanofibers with diameters ranging from 150 nm to 1.6 µm.…”

Section: Resultsmentioning

confidence: 99%

Chitosan Imparts Better Biological Properties for Poly(ε-caprolactone) Electrospun Membranes than Dexamethasone

Machado

Roberto

Bonafé

et al. 2019

J. Braz. Chem. Soc.

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Poly(ε-caprolactone), an aliphatic polyester with biodegradability and cytocompatibility, has been used to create scaffolds for tissue engineering purposes. However, the hydrophobicity and low water absorptivity of poly(ε-caprolactone) reduce cell anchorage on their membranes. Here, poly(ε-caprolactone)-based scaffolds were prepared by electrospinning of poly(ε-caprolactone)chitosan blend, and poly(ε-caprolactone)-dexamethasone solution. Chitosan and dexamethasone play an essential role to increase the scaffolding performance of poly(ε-caprolactone)-based electrospun membranes. A poly(ε-caprolactone) membrane without chitosan and dexamethasone did not provide satisfactory results to promote cell culture of adipose mesenchymal stem cells (AMSCs). Compared to the poly(ε-caprolactone)-dexamethasone surface, poly(ε-caprolactone)chitosan membrane imparts better cytoskeletal reorganization, and cell spreading, increasing the strength of cell attachment. Also, poly(ε-caprolactone)-chitosan composite provides strong antimicrobial activity against Pseudomonas aeruginosa (ca. 90% inhibition). Therefore, the poly(ε-caprolactone)-chitosan composite is a better alternative to treat skin diseases and promote skin regeneration than conventional approaches based on dexamethasone.

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Section: Resultsmentioning

confidence: 99%

Chitosan Imparts Better Biological Properties for Poly(ε-caprolactone) Electrospun Membranes than Dexamethasone

Machado

Roberto

Bonafé

et al. 2019

J. Braz. Chem. Soc.

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“…14,15 In order to benefit from the advantages of different materials in a single scaffold, electrospun composites are prepared. Many polymer blends and composites have been electrospun into a single mat using single or twin extrusion systems such as PCL/chitosan blend, 16 polycaprolactonegelatin, 17 silk fibroin-poly(ε caprolactone) blended/poly(ε caprolactone). 18 Furthermore, core-shell fibers can also be produced using the coaxial electrospinning method.…”

Section: Introductionmentioning

confidence: 99%

Enhancing structural strength and improving cell survival through Polycaprolactone/(gelatin/hydroxyapatite) Core‐Shell nanofibers for tissue engineering

et al. 2022

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Bone tissue engineering is a practical approach to repairing broken or damaged bones that combines scaffold, cells, and growth factors for treatment. In this study, polycaprolactone (PCL)/gelatin (Ge)/hydroxyapatite (HA) core‐shell nanocomposites have been produced by the coaxial electrospinning method. Coaxial electrospinning is an efficient method for scaffold preparation to provide an interconnected porous fibrous scaffold. The prepared nanocomposite simultaneously benefited from the good mechanical behavior of the core PCL polymer. The desired biological properties also originated from the outer layer of the Ge/HA nanocomposite. Nanofibrous scaffolds' properties were characterized using SEM, TEM, FTIR, TGA, DSC, tensile test, contact angle, and MTT assay. The morphology of the as‐electrospun nanofibers was investigated using SEM and TEM, which revealed a defect‐less fibrous morphology. TEM images showed the core‐shell structure of the prepared scaffold nanofibers. The contact angle test showed that the presence of HA nanoparticles has improved the wettability of fibrous composites. In addition, HA nanoparticles could effectively strengthen the polymer scaffolds. The highest UTS value of 4.1 MPa was obtained in the PCL/(Ge+10%HA) sample. The cytotoxicity results revealed that the prepared scaffolds were utterly biocompatible. Moreover, significant cell proliferation of osteosarcoma cells was observed at high HA contents. The interconnected pores allowed cells to migrate into the scaffolds and grow inside. Based on the obtained results, PCL/(Ge/ HA) core‐shell nanofibers could be a promising candidate for bone scaffolds.

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“…The developed composite CS–PCL scaffolds showed a faster degradation rate, more hydrophilicity, and higher thermostability, which could make them a good candidate for biomedical applications [ 24 , 25 ]. Numerous studies have shown that CS–PCL membranes are suitable and promising candidates as vascular grafts, wound dressing for the controlled release of drugs, and carriers of encapsulated enoxaparin [ 26 , 27 , 28 , 29 ]. Furthermore, recent efforts have contributed to mediating the cellular osteogenic growth peptide gene by combining amphiphilic CS, PCL, and bioglass, and gene transfection efficiency was dramatically enhanced in the experimental conditions [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

Thermal Stability and Dynamic Mechanical Properties of Poly(ε-caprolactone)/Chitosan Composite Membranes

Zhang

Yang

et al. 2021

Materials

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Poly (ε-caprolactone) (PCL) and chitosan (CS) are widely used as biodegradable and biocompatible polymers with desirable properties for tissue engineering applications. Composite membranes (CS–PCL) with various blend ratios (CS:PCL, w/w) of 0:100, 5:95, 10:90, 15:85, 20:80, and 100:0 were successfully prepared by lyophilization. The thermal stabilities of the CS–PCL membranes were systematically characterized by thermogravimetric analysis (TG), dynamic thermogravimetry (DTG), and differential scanning calorimetry (DSC). It was shown that the blend ratio of PCL and CS had a significant effect on the thermal stability, hydrophilicity, and dynamic mechanical viscoelasticity of the CS–PCL membranes. All the samples in the experimental range exhibited high elasticity at low temperature and high viscosity at high temperatures by dynamic mechanical thermal analysis (DMTA). The performances of the CS–PCL membranes were at optimum levels when the blend ratio (w/w) was 10:90. The glass transition temperature of the CS–PCL membranes increased from 64.8 °C to 76.6 °C compared to that of the pure PCL, and the initial thermal decomposition temperature reached 86.7 °C. The crystallinity and porosity went up to 29.97% and 85.61%, respectively, while the tensile strength and elongation at the breakage were 20.036 MPa and 198.72%, respectively. Therefore, the 10:90 (w/w) blend ratio of CS/PCL is recommended to prepare CS–PCL membranes for tissue engineering applications.

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Pcl/Chitosan Blended Nanofibrous Tubes Made by Dual Syringe Electrospinning

Cited by 9 publications

References 22 publications

Chitosan Imparts Better Biological Properties for Poly(ε-caprolactone) Electrospun Membranes than Dexamethasone

Chitosan Imparts Better Biological Properties for Poly(ε-caprolactone) Electrospun Membranes than Dexamethasone

Enhancing structural strength and improving cell survival through Polycaprolactone/(gelatin/hydroxyapatite) Core‐Shell nanofibers for tissue engineering

Thermal Stability and Dynamic Mechanical Properties of Poly(ε-caprolactone)/Chitosan Composite Membranes

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