PCL- b -P(MMA- co -DMAEMA) 2 new triblock copolymer for novel pH-sensitive nanocapsules intended for drug delivery to tumors

Franco, Camila; Antonow, Michelli Barcelos; Beckenkamp, Aline; Buffon, Andréia; Ceolin, Taíse; Tebaldi, Marli Luiza; Silveira, Gustavo Pozza; Guterres, Sílvia Stanisçuaski; Pohlmann, Adriana Raffin

doi:10.1016/j.reactfunctpolym.2017.08.010

Cited by 7 publications

(5 citation statements)

References 46 publications

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“…28 Compared to the synthesized polymer-based DOX containing nanoparticle (60 nm), DELNPs without any surfactant added during the synthesis had a relatively larger size. 29 The EE in the DELNP-C1, C2, and C4 was 64 ± 13, 73 ± 7, and 69 ± 11%, respectively (Figure 2). Despite the larger DOX size (543.52 g mol −1 ) than coumarin 6 (350.40 g mol −1 ), DELNP has a higher drug-entrapping ability than CELNP.…”

Section: ■ Results and Discussionmentioning

confidence: 95%

“…The average particle size of DELNPs suggests that they not only release drugs but also can directly go through fenestrated tumor vascular endothelium (200–780 nm) or lung (1–400 nm) . Compared to the synthesized polymer-based DOX containing nanoparticle (60 nm), DELNPs without any surfactant added during the synthesis had a relatively larger size …”

Section: Resultsmentioning

confidence: 99%

“…These trends are strong evidence of successful drug encapsulation by lignin, since if the drug molecules are adsorbed on the surface of the lignin particle, then its colloidal stability changes. 33 Since it is reported that several polymer-based drug-encapsulated nanoparticles have difficulty in sustaining high surface charge, 29,34,35 kraft lignin could be a good candidate for the fabrication of a hydrophobic drug carrier.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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In Vitro and In Vivo Evaluation of Drug-Encapsulated Lignin Nanoparticles for Release Control

Lee

Jin

et al. 2022

ACS Sustainable Chem. Eng.

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In this study, kraft lignin was used as a polymer for drug-encapsulated nanoparticle synthesis (coumarin 6 and doxorubicin; DOX). Successful drug encapsulation by nanoprecipitation was confirmed (max. 59% for coumarin 6 and max. 73% for DOX). Compared with the pure lignin nanoparticle, drug-encapsulated nanoparticles showed no remarkable change in their size (i.d. 176–469 nm) and surface charge (−40.5 to −32.7 mV) regardless of the drug in the particle. The drug-release profiles of the particles showed that they follow the Fickian diffusion. In vitro cytotoxicity assay revealed that the drug-release effect of DOX-encapsulated nanoparticles was delayed but the anticancer activity was not decreased. In addition, the hemocompatibility test, in vivo allergic reaction test, and tumor inhibition assays using tumors in mice showed high biocompatibility of the lignin-based drug delivery system and reduced side effects during chemotherapy. This study suggests that kraft lignin has great potential as an eco-friendly and economically sustainable drug delivery system.

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Section: ■ Results and Discussionmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%

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In Vitro and In Vivo Evaluation of Drug-Encapsulated Lignin Nanoparticles for Release Control

Lee

Jin

et al. 2022

ACS Sustainable Chem. Eng.

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“…A particular interest to PDMAEMA-based gels is driven by their antibacterial activity [ 65 ] and applications as non-viral gene delivery systems [ 66 , 67 ]. Although PDMAEMA is a polymer with relatively high cytotoxicity [ 68 , 69 ], toxicity of PDMAEMA gels is strongly reduced by copolymerization of DMAEMA monomers with biocompatible monomers [ 70 , 71 , 72 , 73 ].…”

Section: Fitting Of Experimental Datamentioning

confidence: 99%

Equilibrium Swelling of Biocompatible Thermo-Responsive Copolymer Gels

Drozdov

2021

Gels

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Biomedical applications of thermo-responsive (TR) hydrogels require these materials to be biocompatible, non-cytotoxic, and non-immunogenic. Due to serious concerns regarding potential toxicity of poly(N-isopropylacrylamide) (PNIPAm), design of alternative homo- and copolymer gels with controllable swelling properties has recently become a hot topic. This study focuses on equilibrium swelling of five potential candidates to replace PNIPAm in biomedical and biotechnological applications: poly(N-vinylcaprolactam), poly(vinyl methyl ether), poly(N,N-dimethyl amino ethyl methacrylate), and two families of poly(2-oxazoline)s, and poly(oligo(ethylene glycol) methacrylates). To evaluate their water uptake properties and to compare them with those of substituted acrylamide gels, a unified model is developed for equilibrium swelling of TR copolymer gels with various types of swelling diagrams. Depending on the strength of hydrophobic interactions (high, intermediate, and low), the (co)polymers under consideration are split into three groups that reveal different responses at and above the volume phase transition temperature.

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“…The peak at 177 ppm, which verified the grafting reaction, was attributed to the carbonyl group (>C O) of PDMA. [22] The DSC and TGA/DTG thermograms of the CRG-g-PDMA 1 (GR = 25%) and CRG-g-PDMA 2 (GR = 92%) are displayed in Figure 2. In the earlier study, [15] the CRG polymer displayed two endothermic peaks at 189.85 C and 218.74 C, and then an exothermic peak at 238.04 C. In addition, in that study, T g value of CRG was found to be 86.32 C. [15] In this study, with the incorporation of PDMA groups, the exothermic peaks shifted to high temperatures, while the endothermic peaks disappeared.…”

Section: Reversibility Of Swellingdeswelling Behaviormentioning

confidence: 99%

pH/temperature‐responsive poly(dimethylaminoethyl methacrylate) grafted κ‐carrageenan copolymer: Synthesis and physicochemical properties

Geyik

Işıklan

2020

J of Applied Polymer Sci

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κ‐Carrageenan‐graft‐poly(dimethylaminoethyl methacrylate) (CRG‐g‐PDMA) was synthesized via free‐radical copolymerization under microwave irradiation. 13C‐Nuclear magnetic resonance spectroscopy (13C‐NMR), fourier‐transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), and X‐ray diffraction (XRD) methods were used for characterization of the CRG‐g‐PDMA structure. The effect of reaction variables including the concentrations of the initiator and dimethylaminoethyl methacrylate (DMA) as well as the microwave irradiation time and power on graft ratio and conversion was investigated, and their highest values were obtained to be 179 and 76%, respectively. The lower critical solution temperatures (LCSTs) of the CRG‐g‐PDMA copolymers were determined at various pH conditions, and their value in distilled water was found as 47°C. Besides, the swelling capacity of the copolymers under different pH levels was investigated and it was seen that the swelling capacity of the copolymer increased with the decrease in the pH value of the medium. The CRG‐g‐PDMA copolymer exhibited excellent swelling performance in acidic pH conditions and possessed responsiveness to pH and temperature stimuli.

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PCL- b -P(MMA- co -DMAEMA) 2 new triblock copolymer for novel pH-sensitive nanocapsules intended for drug delivery to tumors

Cited by 7 publications

References 46 publications

In Vitro and In Vivo Evaluation of Drug-Encapsulated Lignin Nanoparticles for Release Control

In Vitro and In Vivo Evaluation of Drug-Encapsulated Lignin Nanoparticles for Release Control

Equilibrium Swelling of Biocompatible Thermo-Responsive Copolymer Gels

pH/temperature‐responsive poly(dimethylaminoethyl methacrylate) grafted κ‐carrageenan copolymer: Synthesis and physicochemical properties

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