Paucity of Sjogren-like syndrome in a cohort of HIV-1-positive patients in the HAART era. Part II

Panayiotakopoulos, George; Aroni, Kyriaki; Kyriaki, Despina; Paikos, Spyros; Vouyioukas, N.; Vlachos, Adrianna; Kontos, Athanasios; Kordossis, T.

doi:10.1093/rheumatology/keg316

Cited by 40 publications

(28 citation statements)

References 13 publications

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“…The findings in the present study on the effect of HAART on cryoglobulinemia agree with previous studies demonstrating a beneficial effect of HAART in other autoimmune conditions that are associated with HIV infection [Caso et al, 1999;Reveille, 2000;Salliot et al, 2002;Zandman-Goddard and Shoenfeld, 2002;Panayiotakopoulos et al, 2003], but are in contrast with other studies showing an exacerbation of autoimmune manifestations after HAART due to immune reconstitution [Diri et al, 2000;Jubault et al, 2000]. A possible explanation for this discrepancy may be that different pathogenetic mechanisms underlie various autoimmune phenomena.…”

Section: Discussionsupporting

confidence: 93%

Decreased prevalence of mixed cryoglobulinemia in the HAART era among HIV‐positive, HCV‐negative patients

Kosmas

Kontos

Panayiotakopoulos

et al. 2006

Journal of Medical Virology

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There is an established association between human immunodeficiency virus (HIV) infection and mixed cryoglobulinemia, as demonstrated in studies mostly conducted before the introduction of highly active antiretroviral therapy (HAART). To assess the impact of the latter on the cryoglobulinemic status in patients with HIV infection, 133 consecutive, unselected HIV-positive patients, from which only 8 (6%) had co-infection with hepatitis C virus (HCV), were evaluated for the presence of cryoglobulins, according to whether they received or not antiretroviral therapy (ART). Patients shown to be cryoglobulin-positive in a previous study were assessed prospectively, after introducing HAART. Cryoglobulinemia was found in 10 (7.5%) of 133 patients:4 (3.9%) of 101 patients receiving ART versus 6 (18.8%) of 32 patients not receiving ART (P = 0.013). When HCV-positive patients were excluded from the analysis, the correlation between cryoglobulinemia and ART remained significant (P = 0.019). Among 11 previously detected cryoglobulin-positive patients, 8 became cryoglobulin-negative after receiving HAART for a mean period of 6.5 years (P = 0.039). Thus, ART seems to decrease the prevalence of cryoglobulinemia in HIV-infected, HCV-negative patients, a finding which provides indirect evidence of the etiologic role of HIV in the pathogenesis of cryoglobulins.

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Section: Discussionsupporting

confidence: 93%

Decreased prevalence of mixed cryoglobulinemia in the HAART era among HIV‐positive, HCV‐negative patients

Kosmas

Kontos

Panayiotakopoulos

et al. 2006

Journal of Medical Virology

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“…Therefore, antiviral drugs may be an effective treatment for virus-induced xerostomia. In point of fact, the prevalence of DILS has significantly decreased among cohorts of HIV patients since the introduction of highly active antiretroviral treatment (HAART) (1,36).…”

Section: Discussionmentioning

confidence: 99%

Natural Killer Cells Regulate Murine Cytomegalovirus-Induced Sialadenitis and Salivary Gland Disease

Carroll

Lundgren

Wei

et al. 2012

J Virol

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The transmission of herpesviruses depends on viral shedding at mucosal surfaces. The salivary gland represents a major site of persistent viral replication for many viruses, including cytomegalovirus. We established a mouse model of salivary gland dysfunction after acute viral infection and investigated the cellular requirements for the loss of secretion. Murine cytomegalovirus (MCMV) infection severely impaired saliva secretion independently of salivary gland virus levels. Lymphocytes or circulating monocytes/macrophages were not required for secretory dysfunction. Dysfunction occurred before glandular inflammation, suggesting that a soluble mediator initiated the disruption of acinar cell function. Despite genetic differences in innate resistance to MCMV, NK cells protected the host against acinar atrophy and the loss of secretions under conditions of an exceedingly low virus inoculum. NK cells also modulated the type of glandular inflammation after infection, as they prevented an influx of Siglec-F ؉ polymorphonuclear leukocytes (PMNs). Therefore, beyond their recognized role in controlling MCMV replication, NK cells preserve organ integrity and function and regulate the innate inflammatory response within the gland.

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“…Although HAART is important in improving outcomes for PLWHA, its effect on the development of autoimmune diseases is unclear 6. A previous epidemiological study showed that the prevalence of autoimmune disease (eg, Sjögren syndrome) significantly decreased after the initiation of HAART among PLWHA 7. However, a case report suggested that HAART could cause immune restoration inflammatory syndrome and might trigger development of autoimmune diseases 8.…”

Section: Introductionmentioning

confidence: 99%

Incidence of autoimmune diseases in a nationwide HIV/AIDS patient cohort in Taiwan, 2000–2012

Yen

Chuang

Jen³

et al. 2016

Ann Rheum Dis

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Paucity of Sjogren-like syndrome in a cohort of HIV-1-positive patients in the HAART era. Part II

Abstract: It is concluded that SLS, the prevalence of which in the pre-HAART era was 7.8%, has disappeared, possibly as a result of the protective action of HAART.

Cited by 40 publications

References 13 publications

Decreased prevalence of mixed cryoglobulinemia in the HAART era among HIV‐positive, HCV‐negative patients

Decreased prevalence of mixed cryoglobulinemia in the HAART era among HIV‐positive, HCV‐negative patients

Natural Killer Cells Regulate Murine Cytomegalovirus-Induced Sialadenitis and Salivary Gland Disease

Incidence of autoimmune diseases in a nationwide HIV/AIDS patient cohort in Taiwan, 2000–2012

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