Patterns of Sensitization to Inhalant Allergens in Japanese Lower-Grade Schoolchildren and Related Factors

Abstract

were lower in those subjected to maternal passive smoking as well as among boys with pets. AORs of sensitization to JCP alone were lower in those with a history of otitis media, those who had been bottle milk fed, and those who were not the firstborn and who lived near a busy road. Conclusion: Sensitization to HDM and JCP was detected in 51 and 39% of lower-grade schoolchildren, respectively.

Janus-faced Acrolein prevents allergy but accelerates tumor growth by promoting immunoregulatory Foxp3+ cells: Mouse model for passive respiratory exposure

“…This resulted in a relatively high concentration of acrolein with irritative potential at the nasal mucosa of mice during the applications, even though applied dose of acrolein corresponded to levels relevant in passive smoking. The immune effects in mice were, however, fundamental and systemic, and data observed in human smokers and non-smokers validate our model173435363738444546. Last, the molecular mechanisms were eluded by “ in vitro ” studies with reporter cells and antagonists and, therefore, future studies must clearly confirm the specific effects of acrolein on the promiscuous AhR receptor in the light of other receptor candidates.…”

“…In cross-sectional studies maternal smoking decreased the risk of allergic sensitization1735363738. We hypothesized that acrolein as a main compound occurring in cigarette smoke could produce systemic immune suppression, thereby affecting specific B- and T-cell responses and inhibit allergic sensitization.…”

Aeroallergen sensitization and allergic disease phenotypes in Asia

“…16,17 Japanese cedar pollen is a major aeroallergen unique to Japan and has been implicated in allergic airway diseases in Japanese children. [31][32][33] The dispersed cedar pollen load in Japan increased significantly in the last 30 years following maturation of cedar forests planted after the Second World War. Reported sensitization rates in atopic Japanese ranged between 10-30%, second only to house dust mites.…”

Sensitization to Inhalant Allergens in Schoolchildren with Special Reference to Passive Smoking

“…Yamazaki et al [1] conducted a cross-sectional study to determine the factors associated with sensitization to inhalant allergens in schoolchildren. The adjusted odds ratios (AORs) of some of the respiratory symptoms in children and their parents for the sensitization were significantly increased.…”

“…Yamazaki et al [1] presented risk and protective factors for sensitization to inhalant allergens in children by the method of serological epidemiology. As sex and age are both important factors for this association, further study is needed.…”