Patterns of retinal nerve fiber layer loss in multiple sclerosis patients with or without optic neuritis and glaucoma patients

Böck, Markus; Brandt, Alexander U.; Dörr, Jan; Kraft, H; Weinges-Evers, Nicholetta; Gaede, Gunnar; Pfueller, Caspar F.; Herges, Katja; Radbruch, Helena; Ohlraun, Stephanie; Bellmann‐Strobl, Judith; Kuchenbecker, J; Zipp, Frauke; Paul, Friedemann

doi:10.1016/j.clineuro.2010.04.014

Cited by 109 publications

(93 citation statements)

References 22 publications

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“…Although the patterns of RNFL loss are different in ON compared with other diseases such as glaucoma, with the highest degree of RNFL loss in the temporal quadrant, 10,23 our findings are similar to that previously observed in glaucoma patients.…”

Section: Discussionsupporting

confidence: 81%

“…In fact, RNFL thickness in patients with ON and/or MS is thinner than in controls, particularly in the temporal quadrant. 23,24 Rebolleda et al 25 evaluated 50 patients after unilateral ON by Stratus-OCT and they found a significant inverse correlation between the C/D ratios asymmetry and RNFL thickness, mainly in the temporal quadrant. In this study, measurements are higher with Cirrus than Stratus at thinner RNFL values ( Figure 2).…”

Section: Discussionmentioning

confidence: 99%

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Comparison of retinal nerve fiber layer measured by time domain and spectral domain optical coherence tomography in optic neuritis

Rebolleda

García-García²,

Kim³

et al. 2010

Eye

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Purpose To study the relationship between retinal nerve fiber layer (RNFL) thickness measurements from time domain (Stratus) and spectral domain (Cirrus HD) optical coherence tomography (OCT) in subjects with optic neuritis. Methods A total of 18 patients who had suffered monocular acute optic neuritis were imaged by a single trained operator using the Stratus-OCT (fast RNFL scan mode) and Cirrus HD-OCT (optic disc cube mode) on the same day. The relationship between RNFL thickness measurements of the two OCTs (overall and by quadrants) were evaluated using intraclass correlation coefficient (ICC) and Bland-Altman plots. Comparisons between eyes having optic neuritis (ON-group) and fellow eyes (fellow-group) were assessed by a generalized estimating equation (GEE) regression model.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Comparison of retinal nerve fiber layer measured by time domain and spectral domain optical coherence tomography in optic neuritis

Rebolleda

García-García²,

Kim³

et al. 2010

Eye

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“…Recent studies on macular region and NFL composition revealed a reduced thickness in both macular area as well as NFL thickness in MS patients compared with controls. 13,14,30 In addition, Bock et al measured no difference in retinal NFL loss between MS patients and glaucoma patients. 30 However, it is unclear if there is a shared mechanism involved.…”

Section: Discussionmentioning

confidence: 99%

“…13,14,30 In addition, Bock et al measured no difference in retinal NFL loss between MS patients and glaucoma patients. 30 However, it is unclear if there is a shared mechanism involved. Male gender is Abbreviations: HR, Hazard Ratio; CI, Confidence Interval; N, number of cataract/glaucoma patients; IV, intravenous *analysis includes free-text information on oral and intravenous exposure during MS relapse # : referent: patients without multiple sclerosis; adjusted for age and gender, smoking, body mass index, hypnotics/anxiolytics, anticonvulsants, antidepressants use 6 months prior, diabetes mellitus, chronic obstructive pulmonary disease, cerebrovascular disease, epilepsy and any ocular surgery ever before & : referent: patients without multiple sclerosis; adjusted for age and gender, smoking, body mass index, anticonvulsants, serotonin-selective reuptake inhibitors, tricyclic antidepressants use 6 months prior, cerebrovascular disease, epilepsy and any uveitis ever before § : π: Statistically significant difference (p < 0.05) of the exposure to oral and intravenous glucocorticoids versus non-exposure to oral and IV glucocorticoids 6 months before ¥ : Statistically significant difference (p < 0.05) of the exposure to systemic glucocorticoids versus non-exposure to systemic glucocorticoids ever before π : Statistically significant difference (p < 0.05) of the exposure to oral and intravenous glucocorticoids versus non-exposure to oral and IV glucocorticoids 6 months before ξ : Statistically significant difference (p < 0.05) of the short-course exposure to oral and intravenous glucocorticoids versus non-short-.course exposure to oral and IV glucocorticoids in the year before φ : Statistically significant difference (p < 0.05) of the short-course exposure to oral glucocorticoids versus intravenous short-course exposure to glucocorticoids in the year before reported to be predictive for progression of glaucomatous disease.…”

Section: Discussionmentioning

confidence: 99%

Risk of cataract and glaucoma in patients with multiple sclerosis

et al. 2011

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Background: The aim of the study was to evaluate whether multiple sclerosis (MS) is associated with risk of cataract or glaucoma. Methods:We conducted a population-based cohort study utilizing the UK General Practice Research Database (1987Database ( -2009 linked to the national hospital registry of England (1997England ( -2008. Incident MS patients (5576 cases) were identified and each was matched to six patients without MS (controls) by age, gender, and practice. Cox proportional hazard models were used to estimate hazard ratios (HRs) of incident cataract and glaucoma in MS. Time-dependent adjustments were made for age, history of diseases and drug use. Results: MS patients had no overall increased risk of cataract, adjusted (adj.) HR 1.15 (95% CI 0.94-1.41) or glaucoma, adj. HR 1.02 (95% CI 0.78-1.33). Risk of cataract (adj. HR 2.45 (95% CI 1.56-3.86)) and glaucoma (adj. HR 1.70 (95% CI 1.01-2.86)) was significantly greater in patients < 50 years, particularly in men < 50 years: cataract, adj. HR 4.23 (95% CI 2.22-8.05) and glaucoma, adj. HR 2.76 (95% CI 1.28-5.93). Conclusion: This is the first study which showed that the risk of cataract and glaucoma is elevated in MS patients younger than 50 years, particularly men.

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“…[15][16][17][18][19][20][21][22] MS eyes with a previous history of ON have significant loss of RNFL thickness compared with the eyes of healthy controls and clinically unaffected eyes in the patients with MS. 9,15,22,23 According to a review, Visual System in Relapsing-Remitting Multiple Sclerosis 3…”

Section: Discussionmentioning

confidence: 99%

Relationship between Structural and Functional Assessment of the Visual System in Mildly Disabled Relapsing-Remitting Multiple Sclerosis Patients

Huseyinoglu

Ekinci

Özben

et al. 2014

Neuro-Ophthalmology

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Studies that explored the anterior visual pathway in the patients with multiple sclerosis (MS) have demonstrated contradictory results about the correlation between structural and functional status of optic nerve and retina. We aimed to investigate the functional and structural findings in our cohort of mildly disabled relapsing-remitting MS patients. A total of 134 eyes (80 eyes of the patients with MS and 54 eyes of the control group) were investigated. Eyes of MS patients were divided into two groups-as eyes with history of optic neuritis (ON group) and without history of optic neuritis (NON group). Ophthalmological investigation including visual evoked potentials, standard automated perimetry, and optical coherence tomography were performed for all participants. Retinal and macular thicknesses were significantly decreased in ON and NON groups compared with controls. Also, visual evoked potential latencies and visual field loss were worse in the both MS groups compared with control group. We did not find any correlation between visual evoked potentials and retinal or macular thickness values but visual field parameters were correlated between retinal and macular layer loss in the NON group. According to our results and some previous studies, although both functional and structural changes were detected in patients with MS, functional status markers do not always show parallelism (or synchrony) with structural changes, especially in eyes with history of optic neuritis.

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Patterns of retinal nerve fiber layer loss in multiple sclerosis patients with or without optic neuritis and glaucoma patients

Cited by 109 publications

References 22 publications

Comparison of retinal nerve fiber layer measured by time domain and spectral domain optical coherence tomography in optic neuritis

Comparison of retinal nerve fiber layer measured by time domain and spectral domain optical coherence tomography in optic neuritis

Risk of cataract and glaucoma in patients with multiple sclerosis

Relationship between Structural and Functional Assessment of the Visual System in Mildly Disabled Relapsing-Remitting Multiple Sclerosis Patients

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