Comparison of retinal nerve fiber layer measured by time domain and spectral domain optical coherence tomography in optic neuritis

Abstract

Purpose To study the relationship between retinal nerve fiber layer (RNFL) thickness measurements from time domain (Stratus) and spectral domain (Cirrus HD) optical coherence tomography (OCT) in subjects with optic neuritis. Methods A total of 18 patients who had suffered monocular acute optic neuritis were imaged by a single trained operator using the Stratus-OCT (fast RNFL scan mode) and Cirrus HD-OCT (optic disc cube mode) on the same day. The relationship between RNFL thickness measurements of the two OCTs (overall and by quadrants) were evaluated using intraclass correlation coefficient (ICC) and Bland-Altman plots. Comparisons between eyes having optic neuritis (ON-group) and fellow eyes (fellow-group) were assessed by a generalized estimating equation (GEE) regression model.

Comparative Diagnostic Accuracy of Ganglion Cell-Inner Plexiform and Retinal Nerve Fiber Layer Thickness Measures by Cirrus and Spectralis Optical Coherence Tomography in Relapsing-Remitting Multiple Sclerosis

“…The abnormality rate in temporal pRNFL color code in eyes with previous history of ON was 66.7% by Cirrus and 61.1% by Spectralis. The current study agrees with previous reports that eyes from patients with RRMS exhibit a significant thinning of the pRNFL and GCIPL compared with the healthy eyes [ 7 , 10 , 11 ] and that pRNFL thinning in RRMS patients typically occurs in the temporal sector [ 4 , 20 – 23 , 27 – 29 ].…”

“…LCA requires tests with binary outcomes to create the model. For simplification of the analysis, white, blue, purple, and green sectors have been labeled as “normal,” and yellow and red ones as “abnormal.” For BCVA, values better than or equal to 0.3 LogMAR were labeled as normal and those worse than 0.3 as “abnormal.” BCVA was included in the model in order to provide a functional outcome that could help better define the latent class “retinal thickness change.” Temporal pRNFL was selected as it was the quadrant with a higher frequency of pRNFL thinning and abnormal results in previous studies [ 4 , 20 – 23 ].…”

Color-Code Agreement Among Stratus, Cirrus, and Spectralis Optical Coherence Tomography in Relapsing-Remitting Multiple Sclerosis With and Without Prior Optic Neuritis

“…[3][4][5][6] All of them conclude that there are significant differences in RNFL thickness measurements among instruments despite a high correlation among them. OCT provides information on probable RNFL defects through comparison of the RNFL FIGURE 3.…”

“…There are significant differences among commercially available OCT devices in RNFL thickness measurements in patients with ON and/or relapsingremitting multiple sclerosis, so that RNFL measurements cannot be directly compared. [3][4][5][6] Clinicians should be aware that measurements are generally higher with Stratus than with Cirrus, 4,5 except at thinner RNFL values, and slightly higher on Spectralis compared to Cirrus OCT. 3,6 OCT provides information on probable RNFL defects as 4 color codes through comparison of the RNFL profile with an internal age-matched normative database. Recently, Kim and associates 7 evaluated the color-code agreement between Cirrus and Stratus OCT in patients with glaucoma, and they concluded that color codes were not interchangeable.…”

Anatomical and functional retinal changes in multiple sclerosis

“…8,9,[11][12][13] Briefly, we used the following setting in this study: a fixation target consisting of a red ring 2°in diameter; white, 14 The points are spaced from each other by 6°. The VF is considered reliable when fixation losses were o20%, and falsepositive and false-negative errors o15%.…”