Patterns of Resistance and Therapeutic Synergism among Alkylating Agents1

Double dose-intensive chemotherapy with autologous stem cell support for relapsed and refractory testicular cancer: the University of Michigan experience and literature review

“…[27][28][29][30][31][32] The correlation of drug dose and tumor response, the use of combination chemotherapy to prevent the rapid emergence of drug resistance, and the selection of agents with differing dose-limiting toxicities and mechanisms of action have all influenced trial design.…”

Tumor models for efficacy determination

“…Using this definition, the combination of cyclophosphamide and melphalan administered simultaneously by i.p. injection every 2 weeks was reported to be therapeutically synergistic in the Ridgeway osteosarcoma growth delay assay (89).…”

Neoadjuvant Chemotherapy in Scirrhous Cancer of the Stomach Using Uracil and Tegafur and Cisplatin.

“…With regard to chemotherapy for advanced gastric cancer, as reviewed by Leichman and Berry in 1991 (7), cisplatin-based regimens have been widely adopted as the effective combinations, based on the experimental results ofSchabel et al in which cisplatin-combined chemotherapy has shown synergistic cytotoxicity against murine LI210 leukemia (8) Gastric Cancer Therapy modulation mechanism which would be later described more in detail (14,15).…”