Patterns of Proinflammatory Cytokines and Inhibitors during Typhoid Fever

Keuter, Monique; Dharmana, Edi; Gasem, Muhammad Hussein; Ven-Jongekrijg, J. van der; Djokomoeljanto, R.; Dolmans, W.M.V.; Demacker, P.N.M.; Sauerwein, Robert W.; Gallati, H.; Meer, J.W.M. van der

doi:10.1093/infdis/169.6.1306

Cited by 85 publications

(51 citation statements)

References 36 publications

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“…The pathology observed in hu-SRC-SCID mice infected with S. Typhi resembles human typhoid in a number of respects, including hepatic Kupffer cell swelling and splenic granulomatous inflammation with epithelioid macrophages and multinucleated giant cells (Mallory 1898;Ayhan et al 1973;Bharadwaj et al 2009). Elevated serum levels of the cytokines IL-6, IFN-g, and TNF-a are also observed, as in patients with typhoid fever (Butler et al 1993;Keuter et al 1994). Engraftment of human hematopoietic stem cells into a different mouse background, Rag2 IL2rg null mice, has also been shown to render mice susceptible to S. Typhi infection.…”

Section: Humanized Micementioning

confidence: 99%

Host Specificity of Bacterial Pathogens

Bäumler

Fang

2013

Cold Spring Harbor Perspectives in Medicine

165

134

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Section: Humanized Micementioning

confidence: 99%

Host Specificity of Bacterial Pathogens

Bäumler

Fang

2013

Cold Spring Harbor Perspectives in Medicine

165

134

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“…The clinical and laboratory characteristics are summarized in Tables 1 and 2. The median age of the eight healthy volunteers, two males and six females, was 24 (20)(21)(22)(23)(24)(25) years.…”

Section: Clinical Characteristics Of Patients and Control Subjectsmentioning

confidence: 99%

Cytokine profiles in bronchoalveolar lavage fluid and blood in HIV‐seronegative patients with Pneumocystis carinii pneumonia

Perenboom

Schijndel

Beckers

et al. 1996

Eur J Clin Investigation

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Abstract. Concentrations and ex vivo production of interleukin-(IL-1 /?), tumour necrosis factor-a (TNF), interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL-1RA) and TNF soluble receptors were followed in bronchoalveolar lavage (BAL) fluid and blood from 10 HIV -seronegative patients with Pneumocystis carinii pneumonia (PCP) and compared with values found in healthy volunteers. During the acute phase of PCP, TNF but not IL-6 or IL-1/? was detectable in BAL fluid. At that time, plasma concentrations of the proinfiammatory cyto kines were low, whereas plasma concentrations of the anti-inflammatory cytokines were high. The ex vivo production capacity of proinfiammatory cytokines was suppressed in the acute phase, in the blood as well as at the site of infection. During convalescence the production capacity of the blood cells normalized. The I.L-1RA production capacity of the alveolar cells was also suppressed in the acute phase, but preserved in blood cells.

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“…Of these, the TNF gene, which encodes the pro-inflammatory cytokine TNF-α, is a strong candidate. Keuter et al (1994) measured TNF-α levels in typhoid fever patients and found that the production of this cytokine was lower in the acute phase of the disease than in convalescence. Bhutta et al (1997) have reported an association between circulating TNF-α levels and typhoid fever severity and more recently House et al (2002) showed that low ex vivo production of TNF-α was associated with a delayed recovery.…”

Section: Introductionmentioning

confidence: 99%

A TNF region haplotype offers protection from typhoid fever in Vietnamese patients

et al. 2007

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The genomic region surrounding the TNF locus on human chromosome 6 has previously been associated with typhoid fever in Vietnam. We used a haplotypic approach to understand this association further. Eighty single nucleotide polymorphisms (SNPs) spanning a 150 kb region were genotyped in 95 Vietnamese individuals (typhoid case/mother/father trios). A subset of data from 33 SNPs with a minor allele frequency of >4.3% was used to construct haplotypes. Fifteen SNPs, which tagged the 42 constructed haplotypes were selected. The haplotype tagging SNPs (T1-T15) were genotyped in 380 confirmed typhoid cases and 380 Vietnamese ethnically matched controls. Allelic frequencies of seven SNPs (T1, T2, T3, T5, T6, T7, T8) were significantly different between typhoid cases and controls. Logistic regression results support the hypothesis that there is just one signal associated with disease at this locus. Haplotype-based analysis of the tag SNPs provided positive evidence of association with typhoid (posterior probability 0.821). The analysis highlighted a low-risk cluster of haplotypes that each carry the minor allele of T1 or T7, but not both, and otherwise carry the combination of alleles *12122*1111 at T1-T11, further supporting the one associated signal hypothesis. Finally, individuals that carry the typhoid fever protective haplotype *12122*1111 also produce a relatively low TNF-α response to LPS.

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Patterns of Proinflammatory Cytokines and Inhibitors during Typhoid Fever

Cited by 85 publications

References 36 publications

Host Specificity of Bacterial Pathogens

Host Specificity of Bacterial Pathogens

Cytokine profiles in bronchoalveolar lavage fluid and blood in HIV‐seronegative patients with Pneumocystis carinii pneumonia

A TNF region haplotype offers protection from typhoid fever in Vietnamese patients

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