Patterns of ocular oscillation in oculopalatal tremor

Kim, J. S.; Moon, So Young; Choi, Kwang-Dong; Kim, J. H.; Sharpe, James

doi:10.1212/01.wnl.0000258665.37827.f6

Cited by 81 publications

(63 citation statements)

References 43 publications

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“…However, these data are consistent with previously published data in patients with MS reporting a nystagmus of 2-5 deg amplitude 13,14 and of 3.6 Hz mean frequency 6,[13][14][15] and in patients with OPT a nystagmus of 2-10 deg amplitude 11,16 and of 1-3 Hz frequency. 11,16,17 In addition, we found that the velocity of eye oscillations was higher in patients with OPT than patients with MS, but the cutoff point was not as clear as for frequency. In our study, the main direction of nystagmus was in the torsional and horizontal planes in the MS group and the vertical and torsional planes in the OPT group.…”

Section: Resultssupporting

confidence: 93%

“…This is consistent with previous recordings of 3-dimensional eye motion in APN. 11,15,18,19 Even if the predominant horizontal plane in MS and vertical plane in OPT is a frequent observation, the direction of the nystagmus cannot strictly differentiate between the 2 etiologies. Previous studies that tested APN asymmetry in a subjective way found an equivalent percentage of patients with asymmetric APN (30%-50%) in both MS and OPT groups.…”

Section: Resultsmentioning

confidence: 99%

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Acquired pendular nystagmus in multiple sclerosis and oculopalatal tremor

Tilikete¹,

Jasse²,

Pélisson³

et al. 2011

Neurology

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Objective: Acquired pendular nystagmus occurs mainly in multiple sclerosis (MS) and focal brainstem lesions. In the later case, it is part of the syndrome of oculopalatal tremor. Even though pathophysiology of acquired pendular nystagmus has been clearly characterized experimentally in both etiologies, there is a persisting ambiguity in clinical literature, which leads one to consider both clinical conditions as a common entity. The objective of our work was to compare in a prospective study clinical features, eye movement recording, and functional consequences of acquired pendular nystagmus in 14 patients with oculopalatal tremor and 20 patients with MS. Methods:Besides complete neurologic evaluation, evaluation of visual function, 3-dimensional eye movement recording, and functional scores of the Visual Function Questionnaire were recorded. Results:One patient with oculopalatal tremor and 15 patients with MS disclosed signs of optic neuropathy. The nystagmus in the oculopalatal group showed significant larger mean amplitude (8 deg vs 1 deg), higher mean peak velocity (16 deg/s vs 6 deg/s), lower mean frequency (1-3 Hz vs 4-6 Hz), and larger asymmetry and irregularity of ocular oscillations compared to the MS group. The vision-specific health-related quality of life was more deteriorated in the oculopalatal tremor group than in the MS group. Conclusions:This study emphasizes the need to consider acquired pendular nystagmus in MS and oculopalatal tremor as 2 different clinical entities. This is of particular importance regarding the future evaluation of potential specific effects of pharmacologic agents. Pendular nystagmus corresponds to an enduring to and fro eye oscillation without resetting quick phases. The most common causes of acquired pendular nystagmus (APN) are multiple sclerosis (MS) and focal brainstem lesions. In the later case, APN arises as a feature of the oculopalatal tremor (OPT) syndrome. OPT develops weeks, months, or even years after a single brainstem or cerebellar lesion, 1-3 in most cases a hemorrhagic stroke. It results in synchronized low-frequency tremor of the eyes and palate or other orofacial motor territories and is associated with an hypertrophic degeneration of the inferior olivary nucleus (ION), 2 leading to T2 hypersignal on MRI.1 This condition is triggered by interruption of the GuillainMollaret triangle. 2,4Even though both etiology and clinical aspects appear different in APN associated with MS or OPT, 5 many neurologists are not familiar with the distinct pathogenesis and characteristics of nystagmus in these 2 syndromes. Furthermore, some pharmacologic studies and nystagmus treatment reviews did not differentiate their results according to the underlying etiology. 6 -10 In this study, we aimed to compare clinical features, eye movement recordings, and functional consequences of APN in patients with MS or OPT. The main objective was to emphaFrom the INSERM U1028,

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Section: Resultssupporting

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Acquired pendular nystagmus in multiple sclerosis and oculopalatal tremor

Tilikete¹,

Jasse²,

Pélisson³

et al. 2011

Neurology

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“…When PT is associated with pendular nystagmus, it is called OPT. OPT is a delayed complication of the damage to part of the DROP/GMT except for the dorsal cap of the ION, the dorsolateral reticular formation or the paramedian tract cell groups [22][23][24].…”

Section: Previous Reports On Hypertrophic Olivary Degenerationmentioning

confidence: 99%

Hypertrophic olivary degeneration in children: four new cases and a review of the literature with an emphasis on the MRI findings

Sanverdi¹,

Oguz²,

Haliloğlu³

2012

BJR

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ABSTRACT. Injury to the dentato-rubro-olivary pathway causes hypertrophy and enlargement of the inferior olivary nuclei, which is called hypertrophic olivary degeneration (HOD). To date, adult cases of HOD have usually been reported, and there are only a few individual paediatric cases with limited radiological emphasis in the literature. We present the clinical and MRI findings of four new paediatric cases with HOD. Three of the patients had a posterior fossa surgery, and one did not have an identifiable cause.

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“…OPT is thought to arise from hypersynchronous firing of olivary neurons due to interruption of the supranuclear GABAergic control. 3,4 This abnormal rhythm is subsequently transmitted through ICP to the contralateral cerebellar flocculus and, thus, interferes with physiologic regulations of the oculomotor system. Disruption of the left CTT in this case resulted in hypersynchronous firing from the left ION toward the right cerebellar flocculus.…”

Section: Disclosurementioning

confidence: 99%

“…Recently, the pendular nystagmus has been linked to the structural distortion of the adjacent vertical neural integrators or their efferent projections either by the primary lesion or by the hypertrophied ION. 4 The horizontal one-and-a-half syndrome is characterized by ipsilateral conjugate horizontal gaze palsy and internuclear ophthalmoplegia. The combination results from a unilateral pontine lesion involving the paramedian pontine reticular formation or the abducens nucleus and the ipsilateral medial longitudinal fasciculus.…”

Section: Disclosurementioning

confidence: 99%