Patterns of neurocognitive impairment in first-episode bipolar
                        disorder and schizophrenia

Barrett, Suzanne; Mulholland, Ciaran; Cooper, Stephen; Rushe, Teresa

doi:10.1192/bjp.bp.108.054874

Cited by 77 publications

(72 citation statements)

References 29 publications

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“…In mice, brain regions showing paternal influence are abundant in the hypothalamus and septum areas, which mediate instinctual behavior, such as feeding, mating, and social aggression (Keverne et al 1996a, b). Maternal influence is observed in areas related to development of higher order cognition, which is interesting given that cognition is impaired in BPD and schizophrenia patients (Barrett et al 2009;Schouws et al 2009). Furthermore, imprinting syndromes often exhibit psychiatric comorbidities.…”

Section: Parent-of-origin Effectsmentioning

confidence: 91%

Understanding Bipolar Disorder: The Epigenetic Perspective

Khare

Pal

Petronis

2010

Behavioral Neurobiology of Bipolar Disorder and Its Treatment

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Bipolar disease (BPD) is a complex major psychiatric disorder that affects between 1% and 2% of the population and exhibits ?85% heritability. This has made BPD an appealing target for genetic studies yet, despite numerous attempts, the genetic basis of this disease remains elusive. Recently, it has come to light that epigenetic factors may also influence the development of BPD. These factors act via stable but reversible modifications of DNA and chromatin structure. In this chapter, we revisit the epidemiological, clinical, and molecular findings in BPD and reanalyze them from the perspective of inherited and acquired epigenetic misregulation. Epigenetic research has great potential to enhance our understanding of the molecular basis of BPD.

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Section: Parent-of-origin Effectsmentioning

confidence: 91%

Understanding Bipolar Disorder: The Epigenetic Perspective

Khare

Pal

Petronis

2010

Behavioral Neurobiology of Bipolar Disorder and Its Treatment

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“…Although studies vary widely with respect to sample size and the neuropsychological measures used, virtually all studies demonstrated impaired performance of patient groups compared to healthy individuals on most neuropsychological measures and across cognitive domains. The majority of studies found that schizophrenia patients had greater deficits compared to bipolar patients, 14,[26][27][28][29][30][31][32][33][34][35][36] whereas fewer studies, typically of smaller sample size and perhaps reduced power to detect group effects, reported equivalent performances between these groups. [37][38][39][40][41][42][43][44] Whether bipolar patients in cross-diagnostic comparisons have a history of psychosis is not always specified, which could influence the extent of neuropsychological impairment reported in studies involving these groups; among those studies that do, greater cognitive deficits have been observed among bipolar patients with a history of psychosis than those without.…”

Section: Neuropsychological Impairment In Schizophrenia Schizoaffectmentioning

confidence: 99%

Generalized and Specific Neurocognitive Deficits in Psychotic Disorders: Utility for Evaluating Pharmacological Treatment Effects and as Intermediate Phenotypes for Gene Discovery

Reilly

Sweeney

2014

Schizophrenia Bulletin

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A growing body of research suggests that schizophrenia and bipolar disorder share overlapping clinical, neurobiological, and genetic features, raising important questions about the boundaries and distinctiveness of these 2 major psychiatric disorders. A generalized cognitive impairment has long been understood to be a core feature of schizophrenia. More recently, it has become apparent that cognitive impairment also occurs in bipolar disorder, particularly in those patients with a history of psychotic symptoms. Whether a generalized deficit exists across a spectrum of psychotic disorders is less clearly established. Additionally, in the context of a broad impairment, it remains a significant challenge to identify deficits in specific cognitive processes that may have distinct neurochemical or regional brain substrates and linkages to particular risk-associated genetic factors. In this article, we review the findings from neuropsychological studies across a spectrum that includes schizophrenia, schizoaffective and bipolar disorders, and conclude the available evidence strongly supports that a generalized deficit is present across psychotic disorders that differs in severity more so than form. We then consider the implications of generalized and specific deficits in psychosis for 2 areas of research-the evaluation of pharmacological treatments targeting cognitive deficits, and the investigation of cognitive intermediate phenotypes in family genetic studies. Examples from the literature that touch on the relevance of the generalized deficit in these contexts are provided, as well as consideration for the continued need to identify specific impairments that are separable from the generalized deficit in order to advance drug and gene discovery.

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“…Additionally, impairment in divided attention in patients with bipolar depression has been attributed to a reduction of attentional resources by the central executive (i.e., the working memory component) and impaired activation in the frontal lobe (Paus, Zatorre, & Hofle, 1997). According to the results of the present review, all types of attention are significantly impaired in BD (Ancín et al, 2011;Andersson, Barder, Hellvin, Løvdahl, & Malt, 2008;Barrett, Mulholland, Cooper, & Rushe, 2009;Bonnín et al, 2012;Burdick et al, 2009;Iverson, Brooks, & Young, 2009). Specifically, sustained attention and divided attention are more severe in mania and in depression, respectively (Murphy et al, 1999).…”

Section: Discussionmentioning

confidence: 62%

Attention impairment in bipolar disorder: A systematic review.

Camelo

Velasques

Ribeiro

et al. 2013

Psychology & Neuroscience

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Bipolar disorder (BD) has been associated with marked cognitive impairment, including euthymic periods. Attention is among the most compromised functions in BD. Changes related to learning, memory, and visuospatial abilities can be derived from these attention impairments. The objective of this article is to review the scientific literature on the performance of BD patients in attention tests. A systematic review was performed of controlled studies that assessed attention in patients diagnosed with BD aged between 18 and 65 years. The databases included Medline, LILACS, Cochrane Library, Institute for Scientific Information Web of Knowledge, and Scientific Electronic Library Online (SciELO), and the search encompassed the period from 2008 to 2013. Only studies that had a minimum sample of 10 patients were included. A total of 110 articles fulfilled the inclusion criteria. Compared with healthy control subjects, bipolar patients showed poorer attention performance. Compared with other mental disorders, BD was associated with poorer performance than unipolar depression but better performance than schizophrenia. When bipolar patients in different phases of the disease were compared with one another, the performance of euthymic patients was similar to or better than patients in a depressive state; moreover, manic patients performed worse than depressive patients. Attention is significantly impaired in BD. Attention impairment in BD is milder than in schizophrenia but greater than in unipolar depression. Attention impairment is possibly more severe in manic and depressed episodes than in euthymic periods

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Patterns of neurocognitive impairment in first-episode bipolar disorder and schizophrenia

Cited by 77 publications

References 29 publications

Understanding Bipolar Disorder: The Epigenetic Perspective

Understanding Bipolar Disorder: The Epigenetic Perspective

Generalized and Specific Neurocognitive Deficits in Psychotic Disorders: Utility for Evaluating Pharmacological Treatment Effects and as Intermediate Phenotypes for Gene Discovery

Attention impairment in bipolar disorder: A systematic review.

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