Patterns of metastases in intestinal and diffuse types of carcinoma of the stomach

Duarte, Ignacio; Llanos, O

doi:10.1016/s0046-8177(81)80124-4

Cited by 115 publications

(65 citation statements)

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“…It is usually of the signet-ring cell rather than the gland-forming subtype and has a predilection for metastasizing to the ovaries (Duarte and Llanos, 1981;Holtz and Hart, 1982). When gastric cancer metastasizes to the ovary, the tumor is named a Krukenberg tumor, which is characterized by pleomorphic mucin-filled signet-ring cells accompanied by a sarcomatoid proliferation of the ovarian stroma (Serov et al, 1973).…”

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confidence: 99%

Preferential Loss of Fhit Expression in Signet-Ring Cell and Krukenberg Subtypes of Gastric Cancer

Chang

et al. 2002

Laboratory Investigation

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SUMMARY:Gastric cancer of youth is predominantly a disease of women, usually of the signet-ring cell subtype, with a predilection for metastasizing to the ovaries. The metastatic ovarian tumor is named a Krukenberg tumor. However, the characteristic genetic alterations between the primary gastric cancer and its metastatic ovarian tumor have not been studied. We used laser capture microdissection to procure tissues from 7 patients with gastric cancer who had ovarian metastases (Krukenberg tumor) and tissues from 14 patients with gastric cancer without ovarian metastases. Loss of heterozygosity (LOH) analysis was performed by use of 16 polymorphic markers, which are mapped to the FHIT, APC, p16, BRCA2, p53, BRCA1, and DPC4 loci. Immunohistochemical staining with anti-Fhit antibody was performed in 7 Krukenberg tumors and 92 gastric cancers without ovarian metastases. LOH at the FHIT locus was observed in six (85.7%) of the seven Krukenberg tumors. In contrast, the gastric cancers without ovarian metastases showed a lower frequency (28.6%, 4/14) of LOH at the FHIT locus (p Ͻ 0.05, odds ratio ϭ 1/15). Anti-Fhit antibody showed that expression of Fhit was lost in each of the 7 (100%) Krukenberg tumors but in only 41 (44.6%) of the 92 patients who had gastric cancer without ovarian metastases (p Ͻ 0.05; odds ratio ϭ 1/18.614). Further analysis showed that loss of Fhit expression is highly associated with signet-ring cell type gastric cancer (p Ͻ 0.0001, odds ratio ϭ 62.5) but is not correlated with prognosis. Alteration of the FHIT gene is a characteristic of signet-ring cell type gastric cancer and Krukenberg tumor. (Lab Invest 2002, 82:1201-1208.

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confidence: 99%

Preferential Loss of Fhit Expression in Signet-Ring Cell and Krukenberg Subtypes of Gastric Cancer

Chang

et al. 2002

Laboratory Investigation

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“…However, E-cadherin is necessary for secondary tumor formation in the liver (Osada et al, 1996). In fact, welldifferentiated colorectal or gastric cancers, which express high amounts of E-cadherin at the point of cell-cell contact, often metastasize to the liver; however, liver metastasis of scattered-type undifferentiated cancers is rare (Duarte and Llanos, 1981;Esaki et al, 1990;Yasui et al, 1997). These observations indicate the importance of transient inactivation of the cadherin system during the process of liver metastasis.…”

Section: Genda Et Almentioning

confidence: 99%

Loss of Cell-Cell Contact Is Induced by Integrin-Mediated Cell-Substratum Adhesion in Highly-Motile and Highly-Metastatic Hepatocellular Carcinoma Cells

Genda

Sakamoto²,

Ichida

et al. 2000

Laboratory Investigation

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SUMMARY:The cadherin-mediated cell-cell adhesion system plays a critical role in normal development and morphogenesis.Inactivation of this system is thought to be responsible for cancer invasion and metastasis. A human hepatocellular carcinoma (HCC) cell line, KYN-2, was observed to have great potential for intrahepatic metastasis when orthotopically implanted into the liver of SCID mice. In vitro cultures of KYN-2 cells showed that they formed trabecular structures in suspension but lost tight cell-cell adhesion and became scattered when attached to a substratum such as collagen or fibronectin. In response to adhesion to the substratum, subcellular colocalization of E-cadherin and actin filaments were shown to be reduced, and a significant amount of ␣-catenin was dissociated from the E-cadherin-catenin complex in KYN-2 cells. These changes of cell-cell adhesion were blocked by inhibitory monoclonal antibodies against ␤1 and ␤5 integrins. We found that c-Src was coimmunoprecipitated with E-cadherin-catenin complex and was tyrosine-dephosphorylated and activated in the adherent cells. The tyrosine dephosphorylation of c-Src was induced by cell adhesion to the substratum and inhibited by addition of inhibitory monoclonal antibodies against ␤1 and ␤5 integrins. These findings indicate that integrin-mediated cell-substratum adhesion inhibits cadherin-mediated cell-cell adhesion, possibly through c-Src activation, and suggest that this cross-talk mediates transient inactivation of the cadherin system and plays an important role in intrahepatic metastasis of human HCC. Modulation of this interaction might provide a new approach to prevent metastasis and recurrence of HCC. (Lab Invest 2000, 80:387-394).M etastasis to other parts of the liver through tumor cell dispersal via the portal vein is a common feature of human hepatocellular carcinoma (HCC) (Nakashima, 1976). This intrahepatic metastasis is observed more frequently than extrahepatic metastasis at a relatively early stage of the disease. It is one of the main causes of recurrence within the liver after initial treatment and for the poor prognosis of HCC patients (Nagao et al, 1990;Yuki et al, 1990).Recently we constructed models of intrahepatic metastasis using orthotopic implantation of human HCC cell lines and identified the critical features of HCC cell lines with high metastatic potential (Genda et al, 1999). The highly-metastatic HCC cell lines showed high motility in vitro, mediated by small guanosine triphosphatase Rho and its downstream effector, Rhoassociated kinase, through actin reorganization. Inhibition of cell motility resulted in prevention of intrahepatic metastasis in vivo, indicating that intrahepatic metastasis of HCC is critically regulated by the motility of cancer cells. Rapid and dynamic alterations of the actin cytoskeleton are observed in motile cells; for example, disruption of cortical actin bundles or stress fibers and formation of filopodia or lamellipodia. These structures of actin filaments are linked via cytoplasmic proteins to tr...

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“…El 5 fluoracilo ha demostrado aumento de la supervivencia en el cáncer colorectal (10) aún no se dispone de estudios epidemiológicos en cuanto a anomalías congé-nitas en hijos de madres expuestas a dicho quimioterapéutico (15,16)young age or female sex. Experimental and epidemiological data suggest a protective effect of oestrogen against the induction of (intestinal, solo series de casos que muestran abortos en alrededor del 50% de las pacientes en primer trimestre y restricción del crecimiento intrauterine (RCIU) en segundo y tercer trimester lo que hace importante la vigilancia del crecimiento fetal en las gestantes que cursan con cáncer que require manejo con quimioterapia (17)(18)(19)(20) CASO CLÍNICO #1 Presentamos el caso de una paciente de 34 años G4P3 con gestación de 18 semanas y 3 días al ingreso remitida de un primer nivel de atención por cuadro clínico de un mes de evolución caracterizado por dolor lumbosacro izquierdo de intensidad progresiva, con impresión diagnóstica de urolitiasis, evidencia de anemia normocítica normocrómica con Hb 7.5 g/dL y ecografía renal y de vías urinarias institucional normal. La ecografía de abdomen total mostró hallazgos sugestivos de torsión ovárica izquierda sin abdomen quirúrgico en ese momento.…”

Section: Introductionunclassified

Endocarcinoma gástrico y embarazo reporte de dos casos y revisión de la literatura

et al. 2017

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RESUMENLa incidencia de cáncer durante la gestación es de 1: 1000 a 2000 embarazos, siendo los más frecuentes el de cérvix, mama, ovario, melanoma, tiroides, colon y hematológicos como linfoma y leucemia. A pesar de ser una entidad poco frecuente en el embarazo, se ha visto una tendencia a aumentar en los últimos años debido al incremento progresivo de la edad materna en el momento de la concepción.El carcinoma gástrico es una patología aún menos frecuente, siendo su incidencia durante la gestación de aproximadamente 0.016% a 0.026% en las series de casos de Japón, país con la mayor prevalencia de enfermedad. La cirugía es el tratamiento oncológico menos controversial durante la gestación. En los últimos años, ha cobrado importancia la quimioterapia adyuvante con antineoplásicos de tipo antimetabolito como el 5 fluoracilo (5 -FU), medicamento que ha demostrado mejoría de la supervivencia en pacientes gestantes con adenocarcinoma gástrico. Desafortunadamente, el 96.7% de los casos son diagnosticados en estadíos avanzados, pues su presentación clínica suele confundirse con las manifestaciones propias de la primera mitad de la gestación como son las nauseas y el vomito.Presentamos dos casos clinicos, el de una gestante de 34 años con embarazo de 19 semanas y 3 días al momento del diagnóstico de un carcinoma gástrico Bormann III, llevada a laparotomía con intención curativa a las 21 semanas con hallazgo intraoperatorio de enfermedad metastásica avanzada y tumor ovárico izquierdo sugestivo de tumor de Krukenberg, a quien se le inicia a las 23 semanas quimioterapia paliativa con esquema FOLFIRI el cual recibió hasta la finalización de la gestación a las 33 semanas por restricción del crecimiento intrauterino y posteriormente durante el puerperio; y el de una gestante de 31 años con embarazo de 26 semanas y 6 días quien se ingresa para estudio de emesis persistente durante la gestación con confirmación diagnóstica de adenocarcinoma gástrico Bormann III asociado a Restricción del crecimiento intrauterino que fue llevada a cesárea a las 34 semanas y en el puerperio a gastrectomía total con vaciamiento ganglionar del area celiaca y reconstrucción en Y de Roux.

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Patterns of metastases in intestinal and diffuse types of carcinoma of the stomach

Cited by 115 publications

References 8 publications

Preferential Loss of Fhit Expression in Signet-Ring Cell and Krukenberg Subtypes of Gastric Cancer

Preferential Loss of Fhit Expression in Signet-Ring Cell and Krukenberg Subtypes of Gastric Cancer

Loss of Cell-Cell Contact Is Induced by Integrin-Mediated Cell-Substratum Adhesion in Highly-Motile and Highly-Metastatic Hepatocellular Carcinoma Cells

Endocarcinoma gástrico y embarazo reporte de dos casos y revisión de la literatura

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