Patterns of local recurrence after primary resection of cancers that arise in the sinonasal region and the maxillary alveolus

McMahon, Jeremy; Wong, Ling S.; Crowther, John A.; Taylor, Wilson A.; McManners, J.; Devine, J.C.; Wales, Craig; MacIver, Colin

doi:10.1016/j.bjoms.2012.09.018

Cited by 19 publications

(18 citation statements)

References 11 publications

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“…This site is not so difficult to resect completely; however, our results showed that invasion into this site was related to invasion toward posterior sites, such as the middle cranial fossa. 16 Therefore, tumors invading the orbital apex, pterygoid fossa, or pterygoid plates would induce the involvement of those cranial nerves. Although the risk of lymph node metastasis is relatively low in maxillary sinus cancer, patients with nodal involvement demonstrated a worse prognosis.…”

Section: Discussionmentioning

confidence: 99%

Effect of local extension sites on survival in locally advanced maxillary sinus cancer

et al. 2013

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Section: Discussionmentioning

confidence: 99%

Effect of local extension sites on survival in locally advanced maxillary sinus cancer

et al. 2013

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“…Lesions involving the suprastructure spread by extension through the posterior wall into the pterygomaxillary space, pterygopalatine fossa, infratemporal fossa and the middle cranial fossa; through the roof of the sinus into the orbit; or via the ethmoid cavities to the anterior cranial fossa (Figure 3). Tumors may also track along the infraorbital nerve to the gasserian ganglion 4 . Tumors of the infrastructure, generally produce symptoms early, and thus present at an earlier stage, and are more readily amenable to a satisfactory resection with an excellent chance for local control than lesions of the suprastructure.…”

Section: Presentationmentioning

confidence: 99%

Management of the neck in maxillary sinus carcinomas

Dooley

Shah²

2015

Current Opinion in Otolaryngology & Head and Neck Surgery

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Purpose of Review To discuss and review the role for elective treatment of the neck in maxillary squamous cell carcinoma. Improvements in survival have been seen due to improved local therapies and control, therefore the treatment of the neck has become a topic of debate. Recent findings The risk of occult metastases in neck nodes is higher for T 3-4 tumors. The rate of nodal relapse in the N0 neck without elective treatment is 8-15%. With elective irradiation the nodal relapse rate decreases. However, most nodal relapses are accompanied by local failure or distant disease. Local failure remains the most common site of failure and cause of death in this patient population. Summary Treatment failure occurs overall in 62% of all patients, with local recurrence by far the most common site of treatment failure which is rarely amenable to salvage therapy. Therefore elective neck irradiation is not routinely indicated in the clinically N0 neck; those who recur only in the neck can be surgically salvaged more than 50% of the time.

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“…1,3,4 In addition, multiple clinical, radiological, and histopathological factors have been directly and indirectly associated with survival in oral cavity cancer. 1,4,[7][8][9] Currently, the classification of malignant tumors (TNM) system is the preferred method of tumor staging and is mainly based on anatomical tumor characteristics. 6 For MSCC specifically thus far, these factors include posterosuperior tumor extension, perineural invasion, vasoinvasive growth, positive surgical margins, and postoperative large midfacial defects.…”

Section: Introductionmentioning

confidence: 99%

Predicting individualized mortality probabilities for patients with squamous cell carcinoma of the maxilla: Novel models with clinical and histopathological predictors

2019

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Background The aim of this article was to develop prediction models that calculate postoperative 2‐ and 5‐year mortality probabilities of patients with squamous cell carcinoma of the maxilla (MSCC). Methods Data were collected from the medical records of patients who had been operated between 2000 and 2015 for MSCC. Potential clinical and histopathological predictors were identified. Confounding‐(un)adjusted multivariate Cox and logistic regression models were computed with stepwise backward selection. Internal validation was performed to assess calibration and discriminatory ability. Results Ninety‐five patients with MSCC were included. Two‐year follow‐up was complete, and 85 patients had 5‐year follow‐up. Age, neck treatment, surgical margins, bone invasion, spindle growth, and vasoinvasive growth were associated with mortality. Models were adjusted for confounding with Charlson's comorbidities index. C‐indexes were .841 and .770 respectively, and .838 and .749 after bootstrapping. Conclusion The MSCC‐specific mortality probability can be calculated with new prediction models.

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Patterns of local recurrence after primary resection of cancers that arise in the sinonasal region and the maxillary alveolus

Cited by 19 publications

References 11 publications

Effect of local extension sites on survival in locally advanced maxillary sinus cancer

Effect of local extension sites on survival in locally advanced maxillary sinus cancer

Management of the neck in maxillary sinus carcinomas

Predicting individualized mortality probabilities for patients with squamous cell carcinoma of the maxilla: Novel models with clinical and histopathological predictors

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