“…1,3,4 In addition, multiple clinical, radiological, and histopathological factors have been directly and indirectly associated with survival in oral cavity cancer. 1,4,[7][8][9] Currently, the classification of malignant tumors (TNM) system is the preferred method of tumor staging and is mainly based on anatomical tumor characteristics. 6 For MSCC specifically thus far, these factors include posterosuperior tumor extension, perineural invasion, vasoinvasive growth, positive surgical margins, and postoperative large midfacial defects.…”