Patterns of injury detected by pan-computed tomography after road traffic accidents: retrospective review from a trauma center in Saudi Arabia

Orf, Ali Al; Waheed, Khawaja Bilal; Baig, Aftab Ahmed; Mohammad, Khaled Saleh; Sirafy, Mohamed Nasr El; Amin, Muhammad Sohail; Arulanatham, Zechriah Jebakumar

doi:10.5144/0256-4947.2018.245

Cited by 9 publications

(8 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 6 , 10 , 12 , 15–18 Locally, only one study done by Orf et al reported the rate of negative WBCT in a single institute in the KSA, which was 30.5%. 19 However, this study included only the victims of MVCs.…”

Section: Discussionmentioning

confidence: 99%

<p>Negative Whole-Body Computed Tomography Scans in Polytrauma Patients: A Retrospective Cohort Study</p>

Maghraby

Alshaqaq

AlQattan

et al. 2020

OAEM

View full text Add to dashboard Cite

Background Whole-body computed tomography (WBCT) has been a mainstay and an integral part of the evaluation of polytrauma patients in trauma centers and emergency departments (ED) for a comprehensive evaluation of the extent of injuries. However, routine use of WBCT remains controversial since it exposes patients to radiation and exponentially increases financial expense. The primary objective was to determine the rate of negative WBCT in polytrauma patients. Patients and Methods A retrospective cohort study was conducted at an academic hospital in the Kingdom of Saudi Arabia, which is a dedicated trauma center with a mean of 237,392 ED visits and 10,714 trauma per year. The study included all adult (≥18 years) polytrauma patients who presented to our ED, requiring trauma team activation, and underwent WBCT as part of their evaluation from January 2016 to May 2017. We excluded pediatric patients, patients transferred from another facility, and pregnant patients. The primary endpoint was to measure the rate of negative WBCT in polytraumatized patients. Results A total of 186 patients were included with a mean age of 28.8 ± 12.9 years. The rate of negative WBCT scans was 20.4%. The positive scans were subclassified based on the number of anatomical body regions that were affected radiologically. One body region was affected in 47 patients (31.8%), two body regions were affected in 50 patients (33.8%), and ≥3 body regions were affected in 51 patients (34.3%). In a subset analysis, we identified that oxygen saturation <94% and GCS ≤8 were associated with positive CT scans. Conclusion Our study revealed a slightly higher rate of utilization of WBCT in the management of trauma patients compared to studies with similar practice. We believe that in the correct setting with incorporating high index of suspicion, a physical examination with attention to vital signs and mental status, performing E-FAST, and dedicated X-Rays is a way to potentially reduce the use of WBCT in polytrauma patients.

show abstract

Section: Discussionmentioning

confidence: 99%

<p>Negative Whole-Body Computed Tomography Scans in Polytrauma Patients: A Retrospective Cohort Study</p>

Maghraby

Alshaqaq

AlQattan

et al. 2020

OAEM

View full text Add to dashboard Cite

show abstract

“…A study suggested RTAs to be the country’s main cause of death for 16 to 30-year-old males [6]. Similarly, among 305 individuals presenting at a Saudi trauma center due to road traffic accidents, the median age of young males was 26 years (Interquartile Range, 22-33 years) and that of females was 30 years (Interquartile Range, 28-39) [3]. Another aspect of this information is demonstrated in the fact that in industrialized countries, the gross loss due to accidents is 1 ± 2% of the national income while for the KSA, this loss has been estimated to be between 2.2% and 9% [1,8].…”

Section: Discussionmentioning

confidence: 99%

“…Virtually any body region may be affected by these injuries. According to a study conducted from July 2014 to July 2017, the most frequently injured body region in patients with RTAs included the lower limbs followed by the chest, upper limbs, the head, and the spine [3]. Another study reports intra-abdominal lesions caused by RTAs, in which the larger, solid organs like spleen, liver, and kidneys were reported to be most commonly damaged [4].…”

Section: Introductionmentioning

confidence: 99%

“…It may help to estimate the mortality rate in RTA patients. Literature suggests that patients with severe cerebral and abdominopelvic injuries have a high mortality rate [3]. This may, in turn, provide a better understanding of the severity of individual emergency cases and, therefore, may help the doctors in the emergency department to better triage these cases.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Frequency and Nature of Road Traffic Injuries: Data of More than 10,000 Patients from Ha'il, Saudi Arabia

Ahmed¹,

Mahmood²,

Rizvi³

et al. 2019

Cureus

View full text Add to dashboard Cite

Background Road traffic accidents (RTAs) have become a major issue in today's world. They have caused the loss of more than a million lives in the last decade and are substantially increasing every day. Injuries due to RTAs can cause significant morbidity and mortality. These injuries can be sorted by the type, body region, gender, and age group. We aimed to highlight the frequency and nature of road traffic injuries (RTIs) according to these variables in Ha'il, the Kingdom of Saudi Arabia. Methods A retrospective study was conducted in King Khalid Hospital, Ha'il. Data on the cases of RTIs were collected, which presented to the hospital emergency department from January 1, 2016, to December 31, 2017. Data analysis was then performed using IBM Statistical Package for the Social Sciences 17.0 (SPSS, IBM, NY, USA). Frequencies were calculated using descriptive statistics, and graphs were generated. Results A total of 10,855 patients with RTIs were encountered at the hospital emergency department. Out of these, 8035 patients were males (74.02%) while 2820 were females (25.97%). Fractures of one or more sites were the most common type of injury, encountered in 5173 patients (47.66%). Lacerations occurred in 3487 patients (32.12%). Crush injuries were encountered in 1190 patients (10.96%) while penetrating injuries occurred in 844 patients (7.78%). Abdominal and pelvic visceral injuries were present in 103 patients (0.95%) while thoracic visceral injuries were present in 39 patients (0.36%). Amputations occurred in 19 patients (0.18%). Conclusion Our study highlights the frequency and nature of road traffic injuries that present in the emergency department. As suggested by the high frequency of specific types of injuries, special training should be provided to healthcare professionals to address and treat fractures, head and neck injuries, and serious lacerations effectively.

show abstract

“…Clinically, colorectal cancer (CRC) is a frequently occurring and widely observed malignancy 1 , 2 . Worldwide, CRC is the third and second most common cancer in male and female patients, respectively, and its mortality rate is the fourth and third highest in these groups, respectively 3 , 4 .…”

Section: Introductionmentioning

confidence: 99%

Copanlisib promotes growth inhibition and apoptosis by modulating the AKT/FoxO3a/PUMA axis in colorectal cancer

et al. 2020

View full text Add to dashboard Cite

Colorectal cancer (CRC) is the type of cancer with the third highest incidence and is associated with high mortality and low 5-year survival rates. We observed that copanlisib, an inhibitor of PI3K (pan-class I phosphoinositide 3-kinase) that preferentially inhibits PI3Kδ and PI3Kα, impedes the growth of CRC cells by inducing apoptosis via PUMA. There was a marked increase in the expression of PUMA independent of p53 after treatment with copanlisib. The response of CRC cells to copanlisib could be predicted by PUMA expression. Copanlisib was found to induce PUMA expression through FoxO3a by directly binding to the PUMA promoter after inhibiting AKT signaling. PUMA deficiency mitigated the apoptosis induced by copanlisib. Caspase activation and mitochondrial dysfunction led to copanlisib resistance, as observed through a clonogenic assay, whereas enhanced expression of PUMA increased the copanlisib-induced susceptibility to apoptosis. Moreover, the antitumor effects of copanlisib were suppressed by a deficiency of PUMA in a xenograft model, and caspase activation and reduced apoptosis were also observed in vivo. Copanlisib-mediated chemosensitization seemed to involve the concurrent induction of PUMA expression via mechanisms that were both dependent and independent of p53. These observations indicate that apoptosis mediated by PUMA is crucial for the anticancer effects of copanlisib and that manipulation of PUMA may aid in enhancing anticancer activities.

show abstract

Patterns of injury detected by pan-computed tomography after road traffic accidents: retrospective review from a trauma center in Saudi Arabia

Cited by 9 publications

References 24 publications

<p>Negative Whole-Body Computed Tomography Scans in Polytrauma Patients: A Retrospective Cohort Study</p>

<p>Negative Whole-Body Computed Tomography Scans in Polytrauma Patients: A Retrospective Cohort Study</p>

Frequency and Nature of Road Traffic Injuries: Data of More than 10,000 Patients from Ha'il, Saudi Arabia

Copanlisib promotes growth inhibition and apoptosis by modulating the AKT/FoxO3a/PUMA axis in colorectal cancer

Contact Info

Product

Resources

About