Patterns of impairment in autobiographical memory in the degenerative dementias constrain models of memory

Ivanoiu, Adrian; Cooper, Janine M.; Shanks, Michael F.; Venneri, Annalena

doi:10.1016/j.neuropsychologia.2006.01.030

Cited by 75 publications

(63 citation statements)

References 33 publications

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“…According t o t he Const ruct ive Model, t hese are all abilit ies required in hierarchical search of AM, t hough t here is no consensus as t o t heir relat ive cont ribut ions. Moreover, t he evidence base wit h regard t o t heir cont ribut ion is inconsist ent : semant ic f luency has been shown t o correlat e wit h only semant ic AM (Eust ache et al , 2004;Moses, Culpin, Lowe, & McWilliam, 2004); wit h only episodic AM (Greene, Hodges, & Baddeley, 1995); wit h bot h semant ic and episodic AM (Sart ori, Snit z, Sorcinelli, & Daum, 2004); or not at all (Ivanoiu, Cooper, Shanks, & Venneri, 2006). Similarly diverse result s have been report ed wit h respect t o phonemic f luency (Greene et al , 1995;Ivanoiu et al , 2006;Moses et al , 2004).…”

Section: Insights From Research In Alzheimer's Diseasementioning

confidence: 99%

“…Moreover, t he evidence base wit h regard t o t heir cont ribut ion is inconsist ent : semant ic f luency has been shown t o correlat e wit h only semant ic AM (Eust ache et al , 2004;Moses, Culpin, Lowe, & McWilliam, 2004); wit h only episodic AM (Greene, Hodges, & Baddeley, 1995); wit h bot h semant ic and episodic AM (Sart ori, Snit z, Sorcinelli, & Daum, 2004); or not at all (Ivanoiu, Cooper, Shanks, & Venneri, 2006). Similarly diverse result s have been report ed wit h respect t o phonemic f luency (Greene et al , 1995;Ivanoiu et al , 2006;Moses et al , 2004). Met hodological dif f erences are likely t o explain such inconsist ent result s. For example, most st udies of t he relat ionship bet ween execut ive f unct ion and WM and AM have used t he Aut obiographical Memory Test (AMT; Williams & Broadbent , 1986) which does not allow f or t he measurement of "ment al t ime t ravel" t hat must occur f or t he t ruly episodic reliving of phenomenological det ails (Mat uszewski et al , 2006).…”

Section: Insights From Research In Alzheimer's Diseasementioning

confidence: 99%

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The role of working memory and verbal fluency in autobiographical memory in early Alzheimer's disease and matched controls

et al. 2015

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The role of working memory and verbal fluency in autobiographical memory in early Alzheimer's disease and matched controls. Neuropsychologia, 78. pp. 115-121. ISSN 0028-3932. Link to official URL (if available):http://dx.doi.org/10.1016/j.neuropsychologia. 2015.10.006 This version is made available in accordance with publishers' policies. All material made available by CReaTE is protected by intellectual property law, including copyright law. Any use made of the contents should comply with the relevant law. AbstractRet rieval of aut obiographical memories (AMs) is import ant f or "sense of self ".Previous research and t heoret ical account s suggest t hat working memory (WM) and semant ic and phonemic f luency abilit ies f acilit at e t he hierarchical search f or, and reliving of past , personal event s in t he mind's eye. However, t here remains a lack of consensus as t o t he nat ure of t he relat ionships bet ween t hese cognit ive f unct ions and t he t ruly episodic aspect s of AM. The present st udy t heref ore aimed t o explore t he associat ions bet ween t hese variables in a sample wit h a wide range of cognit ive abilit ies. The st udy incorporat ed a bet ween-groups component , and a correlat ional component wit h mult iple regression. Part icipant s wit h Alzheimer's disease (n = 10) and mat ched healt hy cont rols (n = 10) were assessed on measures of semant ic and episodic AM search and ret rieval, audit ory and spat ial WM, and semant ic and phonemic f luency. The AD group produced less episodic AM cont ent compared t o cont rols. Semant ic f luency predict ed episodic AM ret rieval independent of age ef f ect s but t here were no signif icant relat ionships bet ween measures of phonemic f luency, WM and episodic AM. The result s suggest t hat t he abilit y t o maint ain hierarchical search of t he semant ic knowledge-base is import ant f or t ruly episodic reliving, and int ervent ions f or people wit h AM impairment might t heref ore benef it f rom incorporat ing st ruct ured, individualised ext ernal memory-aids t o f acilit at e AM search and ret rieval. allow f or t he measurement of "ment al t ime t ravel" t hat must occur f or t he t ruly episodic reliving of phenomenological det ails (Mat uszewski et al. , 2006). This is a key limit at ion because it is possible t hat previous associat ions t hought t o occur bet ween execut ive f unct ion or WM and episodic reliving may act ually be 5 Keywords WORKING MEMORY AND VERBAL FLUENCY IN AUTOBIOGRAPHICAL MEMORYrelat ionships wit h semant ic rat her t han episodic AM. This issue is f urt her complicat ed by result s suggest ing a role f or MTL-mediat ed episodic memory in semant ic f luency t asks. For example, Sheldon and Moscovit ch (2012) have demonst rat ed t hat inherent ly aut obiographical semant ic f luency t asks (e. g. "names of f riends") recruit MTL st ruct ures compared t o closed-ended semant ic f luency t asks requiring lit t le spat ial or cont ext ual inf ormat ion (e. g. "t hings t hat are red"), but t hat t here was increa...

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Section: Insights From Research In Alzheimer's Diseasementioning

confidence: 99%

Section: Insights From Research In Alzheimer's Diseasementioning

confidence: 99%

The role of working memory and verbal fluency in autobiographical memory in early Alzheimer's disease and matched controls

et al. 2015

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“…Visual memory for familiar faces was assessed by asking the patient to identify photos of familiar individuals in a set including also unknown people. Semantic memory was measured administering part of the Laiacona et al (1993) [22] test while the test of Ivanoiu et al (2006) [18] was used to test semantic and episodic autobiographical memory. The presence of mood disorders, anosognosia, strategies of compensation to cope with the cognitive deficits and related social disability was also ascertained.…”

Section: Neuropsychological Assessmentmentioning

confidence: 99%

Visuo-Spatial Imagery Impairment in Posterior Cortical Atrophy: A Cognitive and SPECT Study

Gardini

Concari

Pagliara³

et al. 2011

Behavioural Neurology

Self Cite

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Abstract. This study investigated the cognitive profile and the cerebral perfusion pattern in a highly educated 70 year old gentleman with posterior cortical atrophy (PCA). Visuo-perceptual abilities, spatial memory, spatial representation and navigation, visuospatial mental imagery, semantic and episodic-autobiographical memory were assessed. Regional cerebral blood flow (rCBF) was imaged with SPECT. Cognitive testing showed visual-perceptual impairment, apperceptive visual and landmark agnosia, topographical disorientation with way-finding deficits, impaired map learning and poor mental image generation. Semantic memory was normal, while episodic-autobiographical memory was impaired. Reduced rCBF was found mainly in the right hemisphere, in the precentral gyrus, posterior cingulate and middle temporal gyri, cuneus and precuneus, in the left superior temporal and lingual gyri and in the parahippocampus bilaterally. Hypoperfusion in occipito-parietal regions was associated with visuo-spatial deficits, whereas deficits in visuo-spatial mental imagery might reflect dysfunction related to hypoperfusion in the parahippocampus and precuneus, structures which are responsible for spatial and imagery processing. Dissociating performance between preserved semantic memory and poor episodic-autobiographical recall is consistent with a pattern of normal perfusion in frontal and anterior temporal regions but abnormal rCBF in the parahippocampi. The present findings indicate that PCA involves visuo-spatial imagery deficits and provide further validation to current neuro-cognitive models of spatial representation and topographical disorientation.

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“…All the studies agree that in AD, the episodic component of AM is deteriorated [37,48,54,55,57,[59][60][61]. In other words, there are great difficulties in mentally reviving past events and phenomenological aspects such as visual images [48].…”

Section: Autobiographical Memory Decline In the Course Of Alzheimer-tmentioning

confidence: 71%

Behavior and Emotion in Dementia

Rodríguez¹,

Sales²,

RedondoFlores³

et al. 2016

Update on Dementia

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During the course of disease, the patient and caregiver face emotional and behavioral problems that may occur. Therefore, it is important to knowing how emotions and the perception of them are modified and thus to know the impact they have on mood and behavior of the patient and caregiver. Publicizing the type of pathology, both emotional and behavioral levels, in a patient with dementia can help in the development of nonpharmacological interventions that could slow the symptoms and improve the quality of life of patients.

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Patterns of impairment in autobiographical memory in the degenerative dementias constrain models of memory

Cited by 75 publications

References 33 publications

The role of working memory and verbal fluency in autobiographical memory in early Alzheimer's disease and matched controls

The role of working memory and verbal fluency in autobiographical memory in early Alzheimer's disease and matched controls

Visuo-Spatial Imagery Impairment in Posterior Cortical Atrophy: A Cognitive and SPECT Study

Behavior and Emotion in Dementia

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