Patterns of human thyroid parenchymal reaction following low‐dose childhood irradiation

Spitalnik, Patrice F.; Straus, Francis H.

doi:10.1002/1097-0142(197803)41:3<1098::aid-cncr2820410344>3.0.co;2-#

Cited by 74 publications

(10 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Conversely, exposure to viral agents and/or X-irradiation may be examples of conditions that confer on epithelial cells a stimulatory phenotype capable of activating potentially autoreactiveTcel1 clones. For example, reovirus infection is well known to be associated with autoimmune polyendocrine disease [9-141 and childhood X-irradiation results in a high incidence of lymphocytic thyroiditis [28]. It can thus be concluded that a variety of factors that exert control over the phenotype of epithelial cells ultimately determine whether these cells will be protected from, or be the trigger and target of, autoimmune attack.The presence or absence of such factors under highly diverse clinical and experimental settings may also explain the seemingly controversial reports concerning the lymphostimulatory properties of class I1 antigen-expressing epithelial cells [2, 15, 27, 29-3 11.…”

Section: M5 Cellsmentioning

confidence: 99%

Thyroid‐derived epithelial cells acquire alloantigen‐presenting capabilities following X‐irradiation and class II antigen induction

et al. 1990

View full text Add to dashboard Cite

This work was undertaken to further define the antigen-presenting capabilities of thyroid epithelial cells, as this is of paramount importance with regard to their potential to trigger autoimmune thyroiditis. For this purpose we developed the murine cloned thyroid-derived epithelial cell line M.5 which, as previously reported, could be induced to express class II antigens with interferon (IFN)-gamma, but failed to stimulate a primary mixed leukocyte reaction. We now show that M.5 cells acquired alloantigen-presenting function, under conditions in which their replication was arrested by X-irradiation, during a 4-day period of exposure to UV-inactivated reovirus, or to IFN-gamma, for induction of class II antigens. The allostimulatory function by M.5 cells could not be explained on the basis of enhanced class II antigen expression, as equivalent numbers of M.5 cells, irradiated after the 4-day exposure to reovirus, or to IFN-gamma, expressed higher amounts of class II antigens, but did not stimulate a primary mixed leukocyte reaction. Early X-irradiation appeared to induce in the class II-expressing M.5 cells a co-stimulatory signal needed for T cell proliferation, similar to that otherwise provided by phorbol esters in this system. Preservation of alloantigen-presenting function by M.5 cells following fixation indicated that this co-stimulatory activity did not reside in a soluble molecule. We surmise that M.5 epithelial cells must provide a least two signals in order to be able to stimulate lymphocyte populations. Consequently, the mode and conditions of epithelial cell activation may determine whether these cells acquire the capacity to serve as antigen-presenting cells, and ultimately whether or not they are able to induce autoimmune disease.

show abstract

Section: M5 Cellsmentioning

confidence: 99%

Thyroid‐derived epithelial cells acquire alloantigen‐presenting capabilities following X‐irradiation and class II antigen induction

et al. 1990

View full text Add to dashboard Cite

show abstract

“…In contrast, the review of the literature shows a higher incidence of FTC (10-17%) among radiation-induced thyroid malignancies [27][28][29][30][31] than in studies from Belarus. The lower incidence of FTC in children from Belarus could be due to a longer latent period of this type of DTC after radiation exposure.…”

Section: Discussionmentioning

confidence: 73%

Differentiated thyroid cancer in children and adolescents

Farahati

Parlowsky

Mäder

et al. 1998

Langenbeck's Archives of Surgery

View full text Add to dashboard Cite

It can be concluded that in children and adolescents: 1. The incidence of papillary thyroid cancer is higher in females than males, with a peak at puberty. 2. The only significant factor associated with distant metastases is the advanced tumor stage. 3. Childhood thyroid cancer is frequently associated with lymph-node involvement, distant metastases and advanced tumor stage. 4. Papillary childhood thyroid cancer is more aggressive than follicular type.

show abstract

“…It has been suggested that autoimmune conditions may reduce the thyroid gland's resistance to neoplastic processes in the presence of iodine-131 8) . Additionally, the coexistence of benign and malignant lesions has been suggested by previous histopathological studies of patients with a history of radiation exposure 9,10) .…”

Section: Resultsmentioning

confidence: 93%

Thyroid Abnormality Trend Over Time in Northeastern Regions of Kazakstan, adjacent to the Semipalatinsk Nuclear Test Site: A Case Review of Pathological Findings for 7271 Patients

Zhumadilov

Gusev²,

Takada

et al. 2000

JRR

View full text Add to dashboard Cite

Nuclear weapon testing / Semipalatinsk / Thyroid abnormalities/Pathological specimens/Radiationinduced neoplasmsFrom 1949 through 1989 nuclear weapons testing carried out by the former Soviet Union at the Semipalatinsk Nuclear Test Site (SNTS) resulted in local fallout affecting the residents of Semipalatinsk, Ust-Kamenogorsk and Pavlodar regions of Kazakstan. To investigate the possible relationship between radiation exposure and thyroid gland abnormalities, we conducted a case review of pathological findings of 7271 urban and rural patients who underwent surgery from 1966 -96. Of the 7271 patients, 761 (10.5%) were men, and 6510 (89.5%) were women. The age of the patients varied from 15 to 90 years. Overall, a diagnosis of adenomatous goiter (most frequently multinodular) was found in 1683 patients (63.4%) of Semipalatinsk region, in 2032 patients (68.6%) of Ust-Kamenogorsk region and in 1142 patients (69.0%) of Pavlodar region. In the period 1982-96, as compared before, there was a noticeable increase in the number of cases of Hashimoto's thyroiditis and thyroid cancer. Among histological forms of thyroid cancer, papillary (48.1%) and follicular (33.1%) predominated in the Semipalatinsk region. In later periods (1987 -96), an increased frequency of abnormal cases occurred among patients less than 40 years of age, with the highest proportion among patients below 20 in Semipalatinsk and Ust-Kamenogorsk regions of Kazakstan. Given the positive findings of a significant cancer-period interaction, and a significant trend for the proportion of cancer to increase over time, we recommend 36 Z. ZHUMADILOV ET AL. more detailed and etiologic studies of thyroid disease among populations exposed to radiation fallout from the SNTS in comparison to non-exposed population.

show abstract

Patterns of human thyroid parenchymal reaction following low‐dose childhood irradiation

Cited by 74 publications

References 15 publications

Thyroid‐derived epithelial cells acquire alloantigen‐presenting capabilities following X‐irradiation and class II antigen induction

Thyroid‐derived epithelial cells acquire alloantigen‐presenting capabilities following X‐irradiation and class II antigen induction

Differentiated thyroid cancer in children and adolescents

Thyroid Abnormality Trend Over Time in Northeastern Regions of Kazakstan, adjacent to the Semipalatinsk Nuclear Test Site: A Case Review of Pathological Findings for 7271 Patients

Contact Info

Product

Resources

About