Patterns of fos activation in rat raphe nuclei during feeding behavior

Takase, Luiz Fernando; Nogueira, Maria Inês

doi:10.1016/j.brainres.2008.01.036

Cited by 28 publications

(17 citation statements)

References 69 publications

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“…Interestingly, the raphé of rats exposed to restricted feeding schedules (food available for two hours during the day for 15 days early in the light phase of the light dark cycle) show increased c-FOS expression during food search (i.e. prior to meal presentation) in comparison with ad lib controls and animals on the same schedule that are allowed to eat until satiation [27]. Our study confirms these data in mice, and shows that the raphé continues to be active in anticipation of a previously scheduled meal.…”

Section: Discussionmentioning

confidence: 99%

“…Due to various stochastic factors including: missing sections for some animals or failure to meet an appropriate Gunderson's coefficient of error (described below), the first 5 regions (out of the eight total), passing such criterion per group, per brain region, were retained for analysis using the optical fractionator probe within Stereo Investigator v 9 (MBF bioscience, Williston, VT). Regions of interest (ROI), chosen a priori based on previous investigations observing changes in c-FOS under RF [24], [25], [26], [27], [28], [29] were identified using a mouse brain atlas (see Table 1 for a full list of regions, their associated map coordinates, and the sampling parameters used). Cell counting was performed using sampling parameters determined to be sufficient to produce a Gunderson's coefficient of error (GCE, m = 1) less than 0.1.…”

Section: Methodsmentioning

confidence: 99%

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Isolating Neural Correlates of the Pacemaker for Food Anticipation

Blum¹,

Lamont²,

Rodrigues³

et al. 2012

PLoS ONE

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Mice fed a single daily meal at intervals within the circadian range exhibit food anticipatory activity. Previous investigations strongly suggest that this behaviour is regulated by a circadian pacemaker entrained to the timing of fasting/refeeding. The neural correlate(s) of this pacemaker, the food entrainable oscillator (FEO), whether found in a neural network or a single locus, remain unknown. This study used a canonical property of circadian pacemakers, the ability to continue oscillating after removal of the entraining stimulus, to isolate activation within the neural correlates of food entrainable oscillator from all other mechanisms driving food anticipatory activity. It was hypothesized that continued anticipatory activation of central nuclei, after restricted feeding and a return to ad libitum feeding, would elucidate a neural representation of the signaling circuits responsible for the timekeeping component of the food entrainable oscillator. Animals were entrained to a temporally constrained meal then placed back on ad libitum feeding for several days until food anticipatory activity was abolished. Activation of nuclei throughout the brain was quantified using stereological analysis of c-FOS expressing cells and compared against both ad libitum fed and food entrained controls. Several hypothalamic and brainstem nuclei remained activated at the previous time of food anticipation, implicating them in the timekeeping mechanism necessary to track previous meal presentation. This study also provides a proof of concept for an experimental paradigm useful to further investigate the anatomical and molecular substrates of the FEO.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Isolating Neural Correlates of the Pacemaker for Food Anticipation

Blum¹,

Lamont²,

Rodrigues³

et al. 2012

PLoS ONE

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“…Light and sound influence the activity of 5-HT-releasing neurons and extracellular 5-HT across different areas of cortex (Heym et al, 1982;Pum et al, 2008). The ingestion of food increases c-fos immunoreactivity in the dorsal and median raphe nuclei, and the presence of food increases the amount of 5-HT released in response to predator exposure in hippocampus, corpus striatum, amygdala and prefrontal cortex (Rueter and Jacobs, 1996;Takase and Nogueira, 2008). Exposure to TMT increases extracellular 5-HT in the hippocampus, prefrontal cortex, central amygdala and frontal cortex (Hayley et al, 2001;Smith et al, 2006), and restricted movement increases extracellular 5-HT in frontal cortex, amygdala and hippocampus (Mitsushima et al, 2006;Smith et al, 2006;Vahabzadeh and Fillenz, 1994).…”

Section: -Ht Fluctuations During Environmental Eventsmentioning

confidence: 99%

Serotonin in the inferior colliculus fluctuates with behavioral state and environmental stimuli

Hall

Rebec

Hurley

2010

Journal of Experimental Biology

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SUMMARYNeuromodulation by serotonin (5-HT) could link behavioral state and environmental events with sensory processing. Within the auditory system, the presence of 5-HT alters the activity of neurons in the inferior colliculus (IC), but the conditions that influence 5-HT neurotransmission in this region of the brain are unknown. We used in vivo voltammetry to measure extracellular 5-HT in the IC of behaving mice to address this issue. Extracellular 5-HT increased with the recovery from anesthesia, suggesting that the neuromodulation of auditory processing is correlated with the level of behavioral arousal. Awake mice were further exposed to auditory (broadband noise), visual (light) or olfactory (2,5-dihydro-2,4,5-trimethylthiazoline, TMT) stimuli, presented with food or confined in a small arena. Only the auditory stimulus or restricted movement increased the concentration of extracellular 5-HT in the IC. Changes occurred within minutes of stimulus onset, with the auditory stimulus increasing extracellular 5-HT by an average of 5% and restricted movement increasing it by an average of 14%. These findings suggest that the neuromodulation of auditory processing by 5-HT is a dynamic process that is dependent on internal state and behavioral conditions.

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“…For these functions, the FEO is not reliant on any one structure within the network, but employs redundant circuitry during the premeal activity window that drives attention 27, 31, 39–42 , affect or motivation 43–45 , and oscillatory states important for information processing such as hippocampal theta 28, 46 . At the crossroads of this circuitry is the SCN.…”

Section: Discussionmentioning

confidence: 99%

Scheduled feeding restores memory and modulates c-Fos expression in the suprachiasmatic nucleus and septohippocampal complex

Ruby

Fisher

Patton

et al. 2017

Sci Rep

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Disruptions in circadian timing impair spatial memory in humans and rodents. Circadian-arrhythmic Siberian hamsters (Phodopus sungorus) exhibit substantial deficits in spatial working memory as assessed by a spontaneous alternation (SA) task. The present study found that daily scheduled feeding rescued spatial memory deficits in these arrhythmic animals. Improvements in memory persisted for at least 3 weeks after the arrhythmic hamsters were switched back to ad libitum feeding. During ad libitum feeding, locomotor activity resumed its arrhythmic state, but performance on the SA task varied across the day with a peak in daily performance that corresponded to the previous daily window of food anticipation. At the end of scheduled feeding, c-Fos brain mapping revealed differential gene expression in entrained versus arrhythmic hamsters in the suprachiasmatic nucleus (SCN) that paralleled changes in the medial septum and hippocampus, but not in other neural structures. These data show that scheduled feeding can improve cognitive performance when SCN timing has been compromised, possibly by coordinating activity in the SCN and septohippocampal pathway.

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Patterns of fos activation in rat raphe nuclei during feeding behavior

Cited by 28 publications

References 69 publications

Isolating Neural Correlates of the Pacemaker for Food Anticipation

Isolating Neural Correlates of the Pacemaker for Food Anticipation

Serotonin in the inferior colliculus fluctuates with behavioral state and environmental stimuli

Scheduled feeding restores memory and modulates c-Fos expression in the suprachiasmatic nucleus and septohippocampal complex

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