Patterns of expression of the immediate-early gene egr-1 in the accessory olfactory bulb of female mice exposed to pheromonal constituents of male urine

Brennan, Peter; Schellinck, Heather M.; Keverne, E.B.

doi:10.1016/s0306-4522(98)00556-9

Cited by 113 publications

(78 citation statements)

References 31 publications

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“…This response in the neostriatum and ventral hyperstriatum correlates with the strength of tutor song learning (Bolhuis et al, 2000). Learning-related increases in Zif268 expression have also been observed in the accessory olfactory bulb of female mice in response to pheromone signals (Brennan et al, 1999) and in the hippocampus after active avoidance learning (Nikolaev et al, 1992) or brightness discrimination (Grimm and Tischmeyer, 1997), although it is not always possible to dissociate the effects of contextual and stress stimuli from that of learning (see Tischmeyer and Grimm, 1999). The regulation of Zif268 has also been examined in the hippocampus and amygdala in relation to contextual fear conditioning.…”

Section: Regulated Transcription Of Zif268 In Synaptic Plasticity Andmentioning

confidence: 87%

Regulated transcription of the immediate‐early gene Zif268: Mechanisms and gene dosage‐dependent function in synaptic plasticity and memory formation

2002

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ABSTRACT:The immediate-early gene Zif268 is a member of the Egr family of inducible transcription factors. Data from gene expression studies have suggested that this gene may play a critical role in initial triggering of the genetic machinery that has long been considered a necessary mechanism for maintenance of the later phases of LTP and also for the consolidation or stabilization of long-lasting memories. Until recently, however, the data supporting this assumption have been based primarily on circumstantial evidence, with no direct evidence to suggest that Zif268 is required for long-lasting synaptic plasticity and memory. In this report, we review our own data using Zif268 mutant mice; we show that although the early phase of dentate gyrus LTP is normal in these mice, the later phases are not present, and the ability of the mice to maintain learned information over a 24-h period is deficient. In addition, we present new information showing a task-dependent gene dosage effect in Zif268 heterozygous mice. We show that spatial learning is particularly sensitive to reduced levels of Zif268, as one-half of the complement of Zif268 in heterozygous mice is insufficient to maintain spatial long-term memories.

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Section: Regulated Transcription Of Zif268 In Synaptic Plasticity Andmentioning

confidence: 87%

Regulated transcription of the immediate‐early gene Zif268: Mechanisms and gene dosage‐dependent function in synaptic plasticity and memory formation

2002

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“…This regionalization is conserved at the level of the first olfactory relay, the AOB, where V1Rs neurons send projections exclusively to the rostral part of the AOB while the V2Rs neurons project to the caudal part of the AOB. It has been shown that these subdivisions of the VNO and AOB sustain functional differences as they respond differentially to pheromonal stimuli in mice [16,37]. After the first olfactory relay, mitral cells of the AOB project in turn to the medial nucleus of the amygdala, where information processed in the two parts (rostral vs caudal) of the vomeronasal pathway converge when their projections overlap in this structure [111].…”

Section: The Accessory Olfactory Systemmentioning

confidence: 99%

“…Among these proteins that act as carrier for volatile ligands, some, such as major urinary proteins (MUPs) [15,40] or aphrodisin [17] have been now clearly characterized. It should be noticed that these carrier proteins might also serve by themselves as cues for individual recognition, especially because they exhibit a high degree of polymorphism [40] and are able to stimulate egr-1 expression in specific regions of the accessory olfactory bulb [16].…”

Section: Functional Roles Of Both the Main And The Accessory Olfactormentioning

confidence: 99%

The main and the accessory olfactory systems interact in the control of mate recognition and sexual behavior

Keller

Baum

Brock

et al. 2009

Behavioural Brain Research

147

101

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“…The V1R-expressing apical receptor neurons project exclusively to the anterior AOB while the V2R-expressing basal receptors project to the posterior AOB. These two subdivisions of the VNO and AOB respond differentially to pheromonal stimuli in mice [10] and information processed in the two parts of vomeronasal pathway only appears to converge when their projections overlap in the amygdala [83]. As well as differing in their structure, signalling proteins and expression, the two families of vomeronasal receptors also respond to different stimuli.…”

Section: The Vomeronasal System In Mammalsmentioning

confidence: 99%

The evolution of pheromonal communication

Swaney

Keverne

2009

Behavioural Brain Research

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Small-brained rodents have been the principle focus for pheromonal research and have provided comprehensive insights into the chemosensory mechanisms that underpin pheromonal communication and the hugely important roles that pheromones play in behavioural regulation. However, pheromonal communication does not start or end with the mouse and the rat, and work in amphibians reveals much about the likely evolutionary origins of the chemosensory systems that mediate pheromonal effects. The dual olfactory organs (the main olfactory epithelium and the vomeronasal organ), their receptors and their separate projection pathways appear to have ancient evolutionary origins, appearing in the aquatic ancestors of all tetrapods during the Devonian period and so pre-dating the transition to land. While the vomeronasal organ has long been considered an exclusively pheromonal organ, accumulating evidence indicates that it is not the sole channel for the transduction of pheromonal information and that both olfactory systems have been co-opted for the detection of different pheromone signals over the course of evolution. This has also led to great diversity in the vomeronasal and olfactory receptor families, with enormous levels of gene diversity and inactivation of genes in different species. Finally, the evolution of trichromacy as well as huge increases in social complexity have minimised the role of pheromones in the lives of primates, leading to the total inactivation of the vomeronasal system in catarrhine primates while the brain increased in size and behaviour became emancipated from hormonal regulation.

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Patterns of expression of the immediate-early gene egr-1 in the accessory olfactory bulb of female mice exposed to pheromonal constituents of male urine

Cited by 113 publications

References 31 publications

Regulated transcription of the immediate‐early gene Zif268: Mechanisms and gene dosage‐dependent function in synaptic plasticity and memory formation

Regulated transcription of the immediate‐early gene Zif268: Mechanisms and gene dosage‐dependent function in synaptic plasticity and memory formation

The main and the accessory olfactory systems interact in the control of mate recognition and sexual behavior

The evolution of pheromonal communication

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