Patterns of Care and Survival Comparison of Adult and Pediatric Wilms Tumor in the United States: A Study of the National Cancer Database

Saltzman, Amanda F.; Carrasco, Alonso; Amini, Arya; Cost, Nicholas G.

doi:10.1016/j.urology.2019.10.007

Cited by 11 publications

(11 citation statements)

References 22 publications

(52 reference statements)

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“…Two big observational studies have successfully specified clinical, therapeutic, and survival characteristics in adult patients with Wilms' tumor [14,15]. [15].…”

Section: Discussionmentioning

confidence: 99%

“…Two big observational studies have successfully specified clinical, therapeutic, and survival characteristics in adult patients with Wilms' tumor [14,15]. [15]. The standard of treatment of pediatric Wilms' tumor usually involves multimodal therapy; even though surgery is the cornerstone of therapy, many patients will require chemotherapy or adjuvant radiotherapy to improve the probability of response and complete remission of the disease [3,15].…”

Section: Discussionmentioning

confidence: 99%

“…Two big observational studies have successfully specified clinical, therapeutic, and survival characteristics in adult patients with Wilms' tumor [ 14 , 15 ]. The EUROCARE study, published in 2006, reported a cohort of adult patients with Wilms' tumor from Europe, including patients from 15 to 99 years, finding 143 patients in 16 countries, with a median age of presentation of 34 years, an annual incidence of 0.17-0.27 cases per million persons, and a global survival of 69.9% at one year after diagnosis and 47% at five years, with better survival in women than men [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

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Adult Wilms' Tumor: Case Report and Literature Review

Yepes¹,

Bermúdez²,

Camacho-Nieto³

et al. 2021

Cureus

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Wilms' tumor is childhood's most common renal tumor, and its presentation in the adult age is extremely rare. Due to the low frequency in adults, no standard management guidelines are available for this population, also the natural history of the disease and management is unclear. We present a case report of a 31-year-old woman with metastatic Wilms' tumor, with lymph node, lung and liver involvement; systemic treatment with chemotherapy was started, with complete clinical response. Finally, a literature review is performed to showcase the differences in the clinical course, prognosis, and treatment alternatives, in adult disease compared to childhood.

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“…Two big observational studies have successfully specified clinical, therapeutic, and survival characteristics in adult patients with Wilms' tumor [14,15]. [15].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Adult Wilms' Tumor: Case Report and Literature Review

Yepes¹,

Bermúdez²,

Camacho-Nieto³

et al. 2021

Cureus

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“…6 However, a disappointing prognosis still exists for some specific subgroups of patients, including those with an unfavorable histology, relapsed tumors and bilateral/unilateral high-risk tumors. [7][8][9] Moreover, serious chronic health conditions occur in approximately 25% of Wilms tumor survivors. 10 The genetics of Wilms tumor is complex, with multiple oncogenic drivers identified in recent decades.…”

Section: Introductionmentioning

confidence: 99%

Role of FTO gene polymorphisms in Wilms tumor predisposition: A five‐center case–control study

Hua

et al. 2021

The Journal of Gene Medicine

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Background: Wilms tumor is the most frequently occurring renal malignancy in pediatrics. The FTO gene exhibits a featured genetic contribution to cancer development.Nonetheless, its single nucleotide polymorphism (SNP) contribution to Wilms tumor remains unknown.Methods: In the present study, 402 Wilms tumor patients and 1198 healthy controls were successfully genotyped for FTO gene SNPs (rs1477196 G>A, rs9939609 T>A, rs7206790 C>G and rs8047395 A>G) using TaqMan SNP genotyping assays. Odds ratios (ORs) and 95% confidence intervals (CIs), generated from unconditional logistic regression, were applied to quantify the effects of FTO gene SNPs on Wilms tumor risk.Results: We found that the rs8047395 A>G polymorphism was significantly correlated with an increased risk for Wilms tumor (GG versus AA/AG: adjusted OR = 1.38, 95% CI = 1.04-1.85, p = 0.027). Carriers with 1 and 1-2 risk genotypes are more susceptible of developing Wilms tumor than those without risk genotypes. Stratified analysis of rs8047395 and risk genotypes revealed more significant relationships with Wilms tumor risk in certain subgroups. Preliminary functional annotations revealed that the rs8047395 A allele increases expression levels of the FTO gene as determined by expression quantitative trait locus analysis. Conclusions:The present study provides evidence that rs8047395 may regulate FTO gene expression and thus confer susceptibility to Wilms tumor. The candidate FTO gene rs8047395 A>G polymorphism identified in this study warrants independent investigation.

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“…Wilms tumor (WT) is extremely rare in adults, representing <1% of all renal tumors [1,2]. It is a curable disease if managed with multimodal therapy according to the guidelines of pediatric protocols [1,2]. The standard of care in children with WT includes open nephrectomy associated with chemotherapy and sometimes radiotherapy [3].…”

Section: Introductionmentioning

confidence: 99%

Abdominal Recurrence after Robotic Nephron-Sparing Surgery for Wilms Tumor in an Adult Patient

et al. 2021

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A 31-year-old man was referred to an adult urologist for a renal polar mass that measured 7.2 cm in maximum diameter. Robotic assisted complete tumor excision for suspicious renal cell carcinoma was carried out, preserving the rest of the left kidney. Histopathology showed a Wilms tumor (WT) with positive margins. No postoperative therapy was made, and the patient shortly presented an abdominal recurrence. The patient was referred to our pediatric oncology unit; he received preoperative chemotherapy, followed by surgery (completion nephrectomy and removal of neoplastic deposits in the omentum and parietal peritoneum), postoperative chemotherapy, and abdomen radiotherapy. He is well at the 5-year follow-up. Peritoneal dissemination after laparoscopic nephron-sparing surgery (NSS) in a child with a 10-cm WT was previously reported. We suggest open NSS for large WT may be safer than laparoscopic or robotic NSS because carbon dioxide pneumoperitoneum and traumatic handling of tumor may predispose to tumor cell migration. An abdominal WT relapse in adults can be salvaged by multimodal therapy recommended by current pediatric WT guidelines.

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Patterns of Care and Survival Comparison of Adult and Pediatric Wilms Tumor in the United States: A Study of the National Cancer Database

Cited by 11 publications

References 22 publications

Adult Wilms' Tumor: Case Report and Literature Review

Adult Wilms' Tumor: Case Report and Literature Review

Role of FTO gene polymorphisms in Wilms tumor predisposition: A five‐center case–control study

Abdominal Recurrence after Robotic Nephron-Sparing Surgery for Wilms Tumor in an Adult Patient

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