Patterns, Mechanisms and Signals for Intestinal Adaptation

Thomson, A. B. R.; Keelan, M.; Sigalet, D.L.; Fedorak, Richard N.; Garg, Montey; Clandinin, M. T.

doi:10.1159/000171244

Dig Dis

1990

DOI: 10.1159/000171244

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Patterns, Mechanisms and Signals for Intestinal Adaptation

A. B. R. Thomson

M. Keelan²,

D.L. Sigalet³

et al.

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Cited by 9 publications

(1 citation statement)

References 31 publications

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“…Nutrient absorption by the intestine is subject to adaptation (1). For example, there is increased absorption of nutrients in animals with streptozotocin diabetes, or in the remaining intestine following intestinal resection; in contrast there is re-duced absorption of nutrients following abdominal irradiation, with aging, or with the chronic feeding of ethanol (2,3). Alterations in intestinal absorption are associated with changes in the amount and/or type of brush border membrane (BBM) phospholipids of the BBM (4)(5)(6)(7)(8)(9).…”

mentioning

confidence: 99%

Refeeding varying fatty acid and cholesterol diets alters phospholipids in rat intestinal brush border membrane

Keelan

Clandinin

Thomson

1997

Lipids

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Refeeding a diet initially given shortly after weaning results in a different adaptive change in the in vitro intestinal uptake of sugars and lipids than if the diet is given for the first time at a later age. This study was undertaken in rats to test the hypothesis that changes in nutrient uptake associated with refeeding diets containing beef tallow (S), beef tallow plus 1% cholesterol (Sc), fish oil (F), or fish oil plus cholesterol (Fc) are associated with changes in the brush border membrane (BBM) phospholipids and phospholipid fatty acids. Weanling Sprague-Dawley rats were fed ad libitum one of the four diets. At 35 d of age (about 2 wk after weaning), the rats were maintained on either the same diet used at weaning, or were switched to one of the other semisynthetic diets which were then fed for a further 7 wk. At week nine (2 + 7) the rats were either continued on the same diet or were switched back to the original diet for 2 wk (2 + 7 + 2). The groups of animals which were compared included SSSc vs. ScSSc; ScScS vs. SScS; FFFc vs. FcFFc; and FcFcF vs. FFcF. Refeeding S, Sc, F, or Fc had no effect on food consumption or on body weight gain. Refeeding Fc resulted in increased ileal BBM total phospholipids, whereas rechallenge with F resulted in a decline in the jejunal BBM ratio of phospho-lipid/cholesterol. Refeeding Sc resulted in a decrease in the ileal BBM phosphatidylcholine (PC). In rats rechallenged with Fc, there was increased ileal BBM sphingomyelin (SM), increased ileal BBM phosphatidylethanolamine (PE), decreased ileal BBM PC/PE, and an increased ileal BBM SM/PC. Refeeding had no effect on the fatty acyl constituents of the jejunal of ileal BBM PC or PE. These results suggest that there are late effects of the early introduction of dietary cholesterol on intestinal BBM phospholipid content and composition that may contribute to the previously reported changes in intestinal nutrient absorption.

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confidence: 99%

Refeeding varying fatty acid and cholesterol diets alters phospholipids in rat intestinal brush border membrane

Keelan

Clandinin

Thomson

1997

Lipids

Self Cite

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Differential and interactive effects of calcium channel blockers and cholesterol content of the diet on jejunal uptake of lipids in rabbits

Hyson

Thomson

Kappagoda

1994

Lipids

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The present study was undertaken to determine the effects of two classes of calcium channel blockers (CCB), nisoldipine (N) and verapamil (V), on the jejunal uptake of lipids in rabbits. The uptake of cholesterol and long-chain fatty acids into rabbit jejunum was examined after 6 and 36 min of exposure to N or V in vitro ("acute" studies), and after 3-wk feeding of N or V ("chronic" studies). Animals were fed either a low (0.08%) cholesterol diet (LCD) or a high (2.8%) cholesterol diet (HCD), with or without N or V added. Acute in vitro exposure of the jejunum to N or V did not affect the uptake of cholesterol or palmitic acid in rabbits fed LCD or HCD. The effect of N or V feeding depended upon the cholesterol content of the diet; adding N or V to LCD increased cholesterol uptake while adding N or V to HCD enhanced or lowered cholesterol uptake, respectively. Both N and V increased the uptake of stearic acid in LCD. N in HCD had no effect on fatty acid uptake, whereas V lowered the uptake of stearic and linoleic acids and increased the uptake of oleic acid. These changes in lipid uptake were not due to variation in the animals' food intake, body weight gain, or intestinal mucosal surface area. The chronic administration of N or V results in an intestinal adaptative process that alters the jejunal uptake of lipids, the direction of which is influenced by the class of CCB, and by the cholesterol content of the diet. (ABSTRACT TRUNCATED AT 250 WORDS)

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The motor response to intestinal resection: Motor activity in the canine small intestine following distal resection

Quigley

Thompson

1993

Gastroenterology

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Patterns, Mechanisms and Signals for Intestinal Adaptation

Cited by 9 publications

References 31 publications

Refeeding varying fatty acid and cholesterol diets alters phospholipids in rat intestinal brush border membrane

Refeeding varying fatty acid and cholesterol diets alters phospholipids in rat intestinal brush border membrane

Differential and interactive effects of calcium channel blockers and cholesterol content of the diet on jejunal uptake of lipids in rabbits

The motor response to intestinal resection: Motor activity in the canine small intestine following distal resection

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