Patterns in Zika Virus Testing and Infection, by Report of Symptoms and Pregnancy Status — United States, January 3–March 5, 2016

Dasgupta, Sharoda; Reagan‐Steiner, Sarah; Goodenough, Dana; Russell, Kate; Tanner, Mary R.; Lewis, Lillianne; Petersen, Emily E.; Powers, Ann M.; Kniss, Krista; Meaney‐Delman, Dana; Oduyebo, Titilope; O’Leary, Daniel R.; Chiu, Sophia; Talley, Pamela; Hennessey, Morgan; Hills, Susan L.; Cohn, Amanda C.; Gregory, Christopher J.; Laven, Janeen; Kosoy, Olga; Panella, Amanda J.; Fischer, Marc; Calvert, Amanda E.; Basile, Alison Jane; Goodman, Christin H.; Lanciotti, Robert S.; Ledermann, Jeremy P.; Lehman, Jennifer; Mossel, Eric C.; Chu, Katherine; Futoran, Charles; Burns, Paul; Karpathy, Sandor E.; Singleton, Joseph; Kelly, Aubree J.; Allerdice, Michelle E. J.; Priestley, Rachael A.; Fitzpatrick, Kelly; Brooks, Sher’i; Stein, Avi; Lauterbach, Molly; Pappert, Ryan; Replogle, Adam J.; Yockey, Brook; Sexton, Chris C.; Young, John

doi:10.15585/mmwr.mm6515e1

Cited by 33 publications

(25 citation statements)

References 9 publications

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“…Especially, our results demonstrate that viral RNA was abundant in lacrimal fluids in ZIKV-infected adult macaques, supporting the use of tears or lacrimal fluids for clinical diagnosis. ZIKV-associated damages have been documented in babies with microcephaly (de Paula Freitas et al, 2016, Ventura et al, 2016a, Ventura et al, 2016b), and conjunctivitis is also a common symptom in adult ZIKV patients (Dasgupta et al, 2016, Deng et al, 2016, Duffy et al, 2009). Whether the level of viral RNA in body fluids associated with disease severity remains unknown.…”

Section: Discussionmentioning

confidence: 99%

Characterization of a 2016 Clinical Isolate of Zika Virus in Non-human Primates

et al. 2016

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Animal models are critical to understand disease and to develop countermeasures for the ongoing epidemics of Zika virus (ZIKV). Here we report a non-human primate model using a 2016 contemporary clinical isolate of ZIKV. Upon subcutaneous inoculation, rhesus macaques developed fever and viremia, with robust excretion of ZIKV RNA in urine, saliva, and lacrimal fluid. Necropsy of two infected animals revealed that systematic infections involving central nervous system and visceral organs were established at the acute phrase. ZIKV initially targeted the intestinal tracts, spleen, and parotid glands, and retained in spleen and lymph nodes till 10 days post infection. ZIKV-specific immune responses were readily induced in all inoculated animals. The non-human primate model described here provides a valuable platform to study ZIKV pathogenesis and to evaluate vaccine and therapeutics.

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Section: Discussionmentioning

confidence: 99%

Characterization of a 2016 Clinical Isolate of Zika Virus in Non-human Primates

et al. 2016

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“…14, 15 The illness is usually mild, resolves in within a week, and provides immunity to further attacks. 14 Symptoms typically include, inter alia, acute but low fever, body rash (especially in the face and trunk), headache, arthralgia and conjunctivitis, and less commonly including diarrhea, abdominal pain, etc.…”

Section: Clinical Manifestationsmentioning

confidence: 99%

The Epidemic that Shook the World—The Zika Virus Rampage

Nandy¹,

Basak²

2017

Exploratory Research and Hypothesis in Medicine

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The sudden emergence in 2015 of neurologically complex infections attributed to the Zika virus (ZIKV) epidemic in Oceania and South America caught the medical and scientific world by surprise. The virus, which was detected often by serological tests, was known to circulate in Africa and in South/South-East Asian countries, causing mild febrile illness accompanied by nausea and aches, and often confused with dengue and chikungunya. How such an apparently benign virus could suddenly become so highly pathogenic-causing unprecedented levels of infections and an epidemic that affected fetuses in pregnant women to manifest microcephaly and other neurological disorders in newborns-is not yet understood, nor are there any drugs or vaccines to inhibit its progress. In this review, we recount the epidemiological aspects of the ZIKV spread, its clinical manifestations and diagnosis, and the genetics of the virus; we also narrate the efforts to understand the causes of the epidemic strains and discuss different designs of preventives and therapeutics.

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“…Infection with ZIKV during all the trimesters of pregnancy has been associated with fetal anomalies. The highest risk of severe fetal sequelae occurs with infection during the first and second trimesters and may occur among pregnant women with clear symptoms of the disease as well as the asymptomatic ones . The major outcomes include fetal death, microcephaly, cerebral calcifications (parenchymal, periventricular, thalamic, and basal ganglia), ventriculomegaly, hydranencephaly, retardation of growth and neuropsychomotor development, ocular alterations, fetal hydrops, and auditory defects …”

Section: Introductionmentioning

confidence: 99%

Use of induced pluripotent stem cells (iPSCs) and cerebral organoids in modeling the congenital infection and neuropathogenesis induced by Zika virus

Majolo

Marinowic

Moura

et al. 2018

Journal of Medical Virology

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Infection with Zika virus (ZIKV) was recently demonstrated to be associated with damage to the central nervous system, especially microcephaly and the Guillain‐Barré syndrome. This finding had alarmed public health agencies and mobilized institutions around the world to search for more information about the virus, its effects, pathophysiological mechanisms, and potential immunizations and treatments. Given the increasing interest in using iPSCs and cerebral organoids to model the congenital infection and neuropathogenesis induced by ZIKV, the aim of this review was to present an up‐to‐date summary of the publications on the association of ZIKV with microcephaly, using iPSCs and organoids. According to our review, the number of studies has decreased concomitantly with a decrease in the number of cases. The presence of subclinical lesions at birth, which may eventually present cognitive or behavioral problems in the future, suggests that persistent research efforts on the virus should be undertaken by the global health community till the threat is completely wiped out.

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Patterns in Zika Virus Testing and Infection, by Report of Symptoms and Pregnancy Status — United States, January 3–March 5, 2016

Cited by 33 publications

References 9 publications

Characterization of a 2016 Clinical Isolate of Zika Virus in Non-human Primates

Characterization of a 2016 Clinical Isolate of Zika Virus in Non-human Primates

The Epidemic that Shook the World—The Zika Virus Rampage

Use of induced pluripotent stem cells (iPSCs) and cerebral organoids in modeling the congenital infection and neuropathogenesis induced by Zika virus

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