Patterns in antimicrobial susceptibility of Salmonellae isolated at a tertiary care hospital in northern India

Behl, Preeti; Gupta, Varsha; Sachdev, Atul; Guglani, Vishal; Chander, Jagdish

doi:10.4103/ijmr.ijmr_862_14

Cited by 11 publications

(11 citation statements)

References 10 publications

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“…Multidrug-resistant NTS has become a global concern now. Among NTS, susceptibility was observed for ampicillin (0-93%; IQR: 6-67), co-trimoxazole (42-93%; IQR: 54-83), chloramphenicol (45-100%; IQR: 64-100), nalidixic acid (23-76%), ciprofloxacin (9-100%; IQR: 31-88), ceftriaxone and azithromycin (>90%)788586 (CMC, unpublished data). The most common types of ESBLs encountered in NTS were CTX-M and TEM (54%).…”

Section: Typhoidal and Non-typhoidal Salmonellamentioning

confidence: 99%

“…In S. Typhi, the antimicrobial susceptibility profile seen for different antimicrobials were, ampicillin (62-97%; IQR: 85-95), co-trimoxazole (73-98%; IQR: 82-97), chloramphenicol (78-98%; IQR: 90-97), nalidixic acid (0-24%; IQR: 0-19), ciprofloxacin (0-81%; IQR: 2-71), ceftriaxone (64-100%; IQR: 81-100), cefixime (98-100%) and azithromycin (52-97%; IQR: 72-94). For S. Paratyphi A, antimicrobial susceptibility profile reported ampicillin (71-100%; IQR: 84-100), co-trimoxazole (71-100%; IQR: 92-100), chloramphenicol (73-100%; IQR: 87-100), nalidixic acid (0-6%; IQR: 0-4), ciprofloxacin (0-80%; IQR: 2-54), ceftriaxone (46-100%; IQR: 71-100) and azithromycin (50-100%)737475767778798081 (CMC, unpublished data).…”

Section: Typhoidal and Non-typhoidal Salmonellamentioning

confidence: 99%

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Antimicrobial susceptibility profile & resistance mechanisms of Global Antimicrobial Resistance Surveillance System (GLASS) priority pathogens from India

Veeraraghavan¹,

Walia²

2019

Indian J Med Res

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Antimicrobial resistance is a major concern globally. Infections due to drug-resistant pathogens are becoming difficult and a challenge to treat. As treatment choices are limited due to the high-drug resistance rates, there is an increase in the health care cost, duration of hospital stay, morbidity and mortality rates. Understanding the true burden of antimicrobial resistance for a geographical location is important to guide effective empirical therapy. To have a national data, it is imperative to have a systemic data capturing across the country through surveillance studies. Very few surveillance studies have been conducted in India to generate national data on antimicrobial resistance. This review aims to report the cumulative antibiogram and the resistance mechanisms of Global Antimicrobial Resistance Surveillance System (GLASS) priority pathogens from India.

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Section: Typhoidal and Non-typhoidal Salmonellamentioning

confidence: 99%

Section: Typhoidal and Non-typhoidal Salmonellamentioning

confidence: 99%

Antimicrobial susceptibility profile & resistance mechanisms of Global Antimicrobial Resistance Surveillance System (GLASS) priority pathogens from India

Veeraraghavan¹,

Walia²

2019

Indian J Med Res

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“…The antimicrobial susceptibilities of Salmonella isolates were conducted using a modified Kirby-Bauer disk diffusion method (Bauer et al ., 1966). A panel of 12 antibiotics commonly used in human and veterinary medicine belonging to 8 different classes of antibiotics were screened for Penicillin (Amoxicillin+ clavulanic acid 20µg + 10µg, Penicillin 10µg, Oxacillin 1µg), Chloramphenicol (Chloramphenicol 30µg), Aminoglycoside (Gentamicin 10µg), Cephalosporins (Cefazolin 30µg), Sulfonamide (Trimethoprim 5µg), Nitrofurans (Nitrofurantoin 30µg), Quinolones (Nalidixic acid 30µg), Fluoroquinolones (Ofloxacin 5µg, Enrofloxacin 5µg), Polymyxin (Colistin 10µg) were tested.…”

Section: Methodsmentioning

confidence: 99%

“…The antimicrobial susceptibilities of Salmonella isolates were conducted using a modified Kirby-Bauer disk diffusion method (Bauer et al, 1966). A panel of 12 antibiotics commonly used in human Hinton agar plates using sterile cotton swabs.…”

Section: Antimicrobial Susceptibility Profiles Of the Isolatesmentioning

confidence: 99%

Occurrence of Salmonella species in local and commercial chickens slaughtered at Samaru and Sabon-gari live bird markets, Kaduna State

Ashar,

Ameh,

Adamu

et al. 2023

Preprint

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Salmonellosis is a bacterial infection caused by members of the genusSalmonella. It is one of the most common and important zoonotic diseases. The route of infection from animals to humans is usually through contaminated food, water and environment. Bacteriological investigation on 303 cloacal swab samples collected from local (139) and commercial (164) chickens slaughtered at Samaru and Sabon-gari live bird markets, Kaduna State was carried out to determine the occurrence ofSalmonellaspecies. Cultural isolation and identification using conventional biochemical tests, microgen test kit™ and Polymerase Chain Reaction (PCR) amplification ofinvA gene of theSalmonellaisolates was carried out. Isolates were subjected to antimicrobial susceptibility tests, phenotypic detection of Extended Spectrum Beta Lactamases (ESBLs) producingSalmonellaisolates using the modified Clinical and Laboratory Standards Institute (CLSI) ESBL confirmatory test. The occurrence ofSalmonellaspecies based on cultural and biochemical tests was found to be 13 (4.29%), microgen kit identified 7 (53.8%) of the 13Salmonellaspecies while PCR based oninvA gene confirmed 9 (69.2%) as the overall occurrence rate ofSalmonellaspecies. Meanwhile, the study also revealed rate of occurrence ofSalmonellaspecies in local chickens 8 (61.5%) which was higher compared to commercial chickens 1 (7.69%) with a statistical significant association (χ2= 8.775, P = 0.003) between the occurrence ofSalmonellaspecies in local and commercial chickens. Antimicrobial susceptibility testing was carried out using panel of 12 antibiotics from 8 different antibiotic classes. Highest rate of sensitivity of the isolates to antibiotics was observed for Ofloxacin with 90%, while all the isolates (100%) were resistant to Nalidixic Acid, Cefazolin, Amoxicillin + Clavulanic Acid, Oxacillin and Penicillin. This study revealed multidrug-resistance (MDR) profile ofSalmonellawith a total of (25%) ofSalmonellaisolates being resistant to 5 antibiotics belonging to 4 different classes of antimicrobials with the highest multiple antibiotic-resistant (MAR) indices ranging from 0.58 to 0.91. All the nine (9) isolates ofSalmonellatested were found to be negative for ESBLs production. Therefore, it is concluded thatSalmonellaspecies are present in local and commercial chickens slaughtered at Samaru and Sabon-gari live bird markets, Kaduna State and could pose serious public health risks to handlers and to consumers of poultry meat and its products.

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“…that is responsible for entering the host epithelial cells in the intestines thus initiating infection. The inv locus in S. enterica serovar Typhimurium was characterized and it was reported that invA is essential in the display of virulence in the intestine [65].…”

Section: Virulence Genes Of Salmonellamentioning

confidence: 99%

Occurrence of Salmonella Species in Local and Commercial Chickens Slaughtered at Samaru and Sabongari Live Bird Markets, Kaduna State

2023

J Mari Scie Res Ocean

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Salmonellosis is a bacterial infection caused by members of the genus Salmonella. It is one of the most common and important zoonotic diseases. The route of infection from animals to humans is usually through contaminated food, water and environment. Bacteriological investigation on 303 cloacal swab samples collected from local (139) and commercial (164) chickens slaughtered at Samaru and Sabon-gari live bird markets, Kaduna State was carried out to determine the occurrence of Salmonella species. Cultural isolation and identification using conventional biochemical tests, microgen test kit™ and Polymerase Chain Reaction (PCR) amplification of invA gene of the Salmonella isolates was carried out. Isolates were subjected to antimicrobial susceptibility tests, phenotypic detection of Extended Spectrum Beta Lactamases (ESBLs) producing Salmonella isolates using the modified Clinical and Laboratory Standards Institute (CLSI) ESBL confirmatory test. The occurrence of Salmonella species based on cultural and biochemical tests was found to be 13 (4.29%), microgen kit identified 7 (53.8%) of the 13 Salmonella species while PCR based on invA gene confirmed 9 (69.2%) as the overall occurrence rate of Salmonella species. Meanwhile, the study also revealed rate of occurrence of Salmonella species in local chickens 8 (61.5%) which was higher compared to commercial chickens 1 (7.69%) with a statistical significant association (χ2 = 8.775, P = 0.003) between the occurrence of Salmonella species in local and commercial chickens. Antimicrobial susceptibility testing was carried out using panel of 12 antibiotics from 8 different antibiotic classes. Highest rate of sensitivity of the isolates to antibiotics was observed for Ofloxacin with 90%, while all the isolates (100%) were resistant to Nalidixic Acid, Cefazolin, Amoxicillin + Clavulanic Acid, Oxacillin and Penicillin. This study revealed multidrug-resistance (MDR) profile of Salmonella with a total of (25%) of Salmonella isolates being resistant to 5 antibiotics belonging to 4 different classes of antimicrobials with the highest multiple antibiotic-resistant (MAR) indices ranging from 0.58 to 0.91. All the nine (9) isolates of Salmonella tested were found to be negative for ESBLs production. Therefore, it is concluded that Salmonella species are present in local and commercial chickens slaughtered at Samaru and Sabon-gari live bird markets, Kaduna State and could pose serious public health risks to handlers and to consumers of poultry meat and its products.

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Patterns in antimicrobial susceptibility of Salmonellae isolated at a tertiary care hospital in northern India

Cited by 11 publications

References 10 publications

Antimicrobial susceptibility profile & resistance mechanisms of Global Antimicrobial Resistance Surveillance System (GLASS) priority pathogens from India

Antimicrobial susceptibility profile & resistance mechanisms of Global Antimicrobial Resistance Surveillance System (GLASS) priority pathogens from India

Occurrence of Salmonella species in local and commercial chickens slaughtered at Samaru and Sabon-gari live bird markets, Kaduna State

Occurrence of Salmonella Species in Local and Commercial Chickens Slaughtered at Samaru and Sabongari Live Bird Markets, Kaduna State

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