Patterns and Seasonal Variations of Perforated Peptic Ulcer Disease: Experience from Ethiopia

Bekele, Abebe; Kassa, Seyoum; Deneke, Andualem; Taye, Mulat; Wondimu, Sahlu

doi:10.4314/aas.v14i2.7

Cited by 16 publications

(28 citation statements)

References 10 publications

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“…Two studies from Nigeria (one on Five-Year Review of Perforated Peptic Ulcer Disease in Irrua, Nigeria by A. E. Dongo et al and another on Audit of Perforated Peptic Ulcer Disease in a Tropical Teaching Hospital) showed the pick age of their patients to be on 5th decade [12,13] and patients with PUD perforation in developed countries are even more older as seen by the study in Norway by Thorsen K et al (68% of their patients were aged 60 years or older). Similar to a previous study by Abebe B in Minilik II hospital, most of our patients (84.5%) came from the capital city Addis Ababa [14].…”

Section: Discussionsupporting

confidence: 89%

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Pattern and outcome of perforated peptic ulcer disease patient in four teaching hospitals in Addis Ababa, Ethiopia: a prospective cohort multicenter study

Bupicha¹,

Gebresellassie²,

Alemayehu³

2020

BMC Surg

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Background: Perforated peptic ulcer disease is a surgical emergency with a high morbidity and mortality. The socio-demographic characteristic and the factors associated with morbidity and mortality seems to differ between the developed and developing world. This is the first a prospective cohort study in Ethiopia designed to analyze pattern and outcome of patients with perforated peptic ulcer disease in four teaching hospitals affiliated with SOM, CHS of Addis Ababa University. Method: This is a prospective cohort study of patients operated for perforated peptic ulcer disease from June 1, 2018 to May 31, 2019 in four teaching hospital affiliated to department of surgery of SOM, CHS of Addis Ababa university. Result: A total of 97 patients were operated in a year. 86.6% were males with a male to female ratio of 6.5:1. The age group 21-30 were most affected constituting 42.3% of all patients. Mean age is 31.9, Median of 27, age ranges from 16 to 76. Alcohol use (45.4%) and previous history of ulcer disease (75.3%) were the most prevalent risk factors.33% were smokers. Abdominal was present in all and most presented within 48 h (79.4%). 85.6% had pneumo = peritoneum in an x-ray at presentation. Size of the perforation is 10 mm or less in 81.3%. 91(93.8%) had anterior first part duodenum perforation. Repair with pedicled omental patch was done in 65 (67.1%) patients. Age, duration of presentation, hypotension at presentation, size of perforation, degree of peritoneal contamination were found to be the significant factors for morbidity and mortality. Major morbidities were observed in 16 (16.5%) and mortality occurred in 3 (3.1%) patients. Conclusion: Perforation of peptic ulcer disease here occurs in the young. Age, duration of presentation, hypotension at presentation, size of perforation, degree of peritoneal contamination were found to be the significant factors for morbidity and mortality. Morbidity and mortality rate of 16.5 and 3.1% observed here are quite acceptable.

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Section: Discussionsupporting

confidence: 89%

“…Another study from Zewditu Memorial hospital by Assefa Z and G/eyesus A. showed 75% of their patients' with PUD perforation use Khat. The use of this substance is associated with a number of gastrointestinal problems [9,14].…”

Section: Discussionmentioning

confidence: 99%

Pattern and outcome of perforated peptic ulcer disease patient in four teaching hospitals in Addis Ababa, Ethiopia: a prospective cohort multicenter study

Bupicha¹,

Gebresellassie²,

Alemayehu³

2020

BMC Surg

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“…This is due to the fact that the age mix of the disease has changed with more elderly females on NSAIDs and many with serious concomitant medical illnesses (poor American Society of Anaesthesiologists score-ASA) (9). With the younger population in sub-Saharan Africa, the high mortality of PPU (∼20%) is mostly due to the high prevalence of the causative H. pylori and late presentation (10)(11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

An Overview of Gastroduodenal Perforation

Weledji

2020

Front. Surg.

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“…PUP occurs in 2% -10% of patients with ulcer disease, it is the second most frequent complication after bleeding [7]. Gastroduodenal perforation, with leakage of alimentary contents into the peritoneal cavity, is a common surgical emergency associated with morbidity and mortality in 50% and 30% of cases respectively [8] [9].…”

Section: Introductionmentioning

confidence: 99%

Helicobacter Pylori Infections in Peptic Ulcer Perforations: A Retrospective Analysis in Two Referral Hospitals in Douala, Cameroon

Bokalli¹,

McWright²,

Aseneh³

et al. 2020

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Background: Perforations are major complications of peptic ulcer disease and surgical emergencies with important mortality and morbidity. Helicobacter pylori (H. pylori) has been identified as one of the commonest factors associated with peptic ulcer disease. However, little is known about its implication in cases of perforations in Cameroon. We aimed to determine the frequency of Helicobacter pylori infections in cases of perforated peptic ulcers, describe clinical features and outcomes of these cases in Cameroon. Method: A hospital-based retrospective cross-sectional study was conducted through the review of patients' records admitted for peptic ulcer perforations in Laquintinie and Douala General Hospitals over a period of 5 years (January 2014-December 2018). We defined H. pylori infection as; positive result on tissue biopsy at time of surgery. We used SPSS version 23.0 to analyse data and set an alpha value at P = 0.05. Results: We reviewed 115 cases of peptic ulcer perforation, with a mean age of 40 years and sex ratio (M:F) of 5:1. All patients underwent emergency laparotomy, 48 (41%) cases had a biopsy report and the prevalence of H. pylori infection in these cases was 47.9 %. Smoking, alcohol consumption and Non-Steroidal Anti-inflammatory Drugs (NSAIDs) use, were not associated with peptic ulcer perforation. The morbidity was at 43.7% and mortality at 14%. Mortality was increasing with a higher Mannheim Peritonitis Index score

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Patterns and Seasonal Variations of Perforated Peptic Ulcer Disease: Experience from Ethiopia

Cited by 16 publications

References 10 publications

Pattern and outcome of perforated peptic ulcer disease patient in four teaching hospitals in Addis Ababa, Ethiopia: a prospective cohort multicenter study

Pattern and outcome of perforated peptic ulcer disease patient in four teaching hospitals in Addis Ababa, Ethiopia: a prospective cohort multicenter study

An Overview of Gastroduodenal Perforation

Helicobacter Pylori Infections in Peptic Ulcer Perforations: A Retrospective Analysis in Two Referral Hospitals in Douala, Cameroon

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