Patterns and Predictors of Attention-Deficit/Hyperactivity Disorder Persistence into Adulthood: Results from the National Comorbidity Survey Replication

Kessler, Ronald C.; Adler, Lenard A.; Barkley, Russell A.; Biederman, Joseph; Conners, C. Keith; Faraone, Stephen V.; Greenhill, Laurence L.; Jaeger, Savina; Secnik, Kristina; Spencer, Thomas; Üstün, T. Bedirhan; Zaslavsky, Alan M.

doi:10.1016/j.biopsych.2005.04.001

Cited by 560 publications

(376 citation statements)

References 62 publications

(50 reference statements)

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“…[1][2][3][4] Several follow-up studies have shown that at least 30% of ADHD patients diagnosed during childhood continue to suffer the disorder during adolescence and adulthood. [5][6][7][8] The etiology of ADHD is complex, with the involvement of both genetic and environmental factors. Twin, family and adoption studies, however, support the view that there is a major genetic component in its susceptibility.…”

Section: Introductionmentioning

confidence: 99%

Exploration of 19 serotoninergic candidate genes in adults and children with attention-deficit/hyperactivity disorder identifies association for 5HT2A, DDC and MAOB

et al. 2007

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Attention-deficit/hyperactivity disorder (ADHD) is a common psychiatric disorder in which different genetic and environmental susceptibility factors are involved. Several lines of evidence support the view that at least 30% of ADHD patients diagnosed in childhood continue to suffer the disorder during adulthood and that genetic risk factors may play an essential role in the persistence of the disorder throughout lifespan. Genetic, biochemical and pharmacological studies support the idea that the serotonin system participates in the etiology of ADHD. Based on these data, we aimed to analyze single nucleotide polymorphisms across 19 genes involved in the serotoninergic neurotransmission in a clinical sample of 451 ADHD patients (188 adults and 263 children) and 400 controls using a population-based association study. Several significant associations were found after correcting for multiple testing: (1) the DDC gene was strongly associated with both adulthood (P = 0.00053; odds ratio (OR) = 2.17) and childhood ADHD (P = 0.0017; OR = 1.90); (2) the MAOB gene was found specifically associated in the adult ADHD sample (P = 0.0029; OR = 1.90) and (3) the 5HT2A gene showed evidence of association only with the combined ADHD subtype both in adults (P = 0.0036; OR = 1.63) and children (P = 0.0084; OR = 1.49). Our data support the contribution of the serotoninergic system in the genetic predisposition to ADHD, identifying common childhood and adulthood ADHD susceptibility factors, associations that are specific to ADHD subtypes and one variant potentially involved in the continuity of the disorder throughout lifespan.

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Section: Introductionmentioning

confidence: 99%

Exploration of 19 serotoninergic candidate genes in adults and children with attention-deficit/hyperactivity disorder identifies association for 5HT2A, DDC and MAOB

et al. 2007

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“…O TDAH está freqüentemente associado a comprometimentos acadêmico, social e profissional, além de haver maior incidência de transtornos psiquiátricos em portadores quando comparados à população geral, e os sintomas freqüentemente permanecem durante a vida adulta (Kessler et al, 2005). Para o diagnóstico, os sintomas devem gerar comprometimento significativo em pelo menos dois contextos diferentes, além de não serem mais bem explicados por outro transtorno mental.…”

Section: Introductionunclassified

Transtorno do déficit de atenção e hiperatividade: contribuição diagnóstica de avaliação computadorizada de atenção visual

Coutinho

Mattos

Araújo

et al. 2007

Rev. psiquiatr. clín.

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ResumoObjetivo: Identificar se o desempenho num teste de atenção visual permite diferenciar crianças e adolescentes portadoras de TDAH de indivíduos normais. Métodos: 102 crianças e adolescentes com diagnóstico de TDAH, segundo os critérios do DSM-IV, submeteram-se ao Teste de Atenção Visual (TAVIS-III) e tiveram seus desempenhos comparados a 678 controles pareados de um grupo controle. Os indivíduos foram selecionados de duas escolas particulares e uma escola pública, de modo seqüencial com autorização dos pais. Resultados: Uma análise com curvas ROC revelou que os índices tempo médio de reação na tarefa de atenção seletiva, número de erros por omissão na tarefa de atenção alternada e número de erros por ação na tarefa de atenção sustentada, quando comprometidos simultaneamente, revelaram sensibilidade e especificidade elevadas, com um valor preditivo positivo de 87,5%. O valor preditivo negativo da associação de escores normais naqueles três índices foi de 99%. Conclusão: TAVIS-III revelou-se eficiente para discriminar indivíduos normais de portadores de TDAH nesta amostra. , G. et al. / Rev. Psiq. Clín 34 (5); 215-222, 2007 Palavras-chave: Transtorno do déficit de atenção e hiperatividade, atenção, testes neuropsicológicos, diagnóstico. Coutinho AbstractObjective: To investigate if performances in a visual attention test could discriminate between children and adolescents with ADHD and normal subjects. Methods: 102 children and adolescents diagnosed with ADHD according to DSM-IV were submitted to the Test of Visual Attention (TAVIS-III) and had their performance compared to 678 normal paired subjects who comprised a control comparison group. All of the subjects were sequentially recruited from one public and two private schools, following parents' authorization. Results: ROC curves analysis have shown that simultaneous impairment in hit reaction time of focused attention, omission errors in shifted attention and commission errors in sustained attention revealed high sensibility and specificity, with positive predictive value of 87.5%. The negative predictive value was of 99% when the aforementioned indexes occurred simultaneously within normal range. Conclusion: The Test of Visual Attention (TAVIS-III) was efficient to discriminate persons with ADHD and normal persons in this non clinical sample. , G. et al. / Rev. Psiq. Clín 34 (5); 215-222, 2007 Coutinho

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“…Controlling for severity and excluding treatment, none of the other variables (sociodemographics, childhood adversity, traumatic life experiences and comorbidity) significantly predicted persistence, even though they were significantly associated with childhood ADHD [30]. Many studies reported adult persistence was much greater for inattention than for hyperactivity/impulsivity [6,30].…”

Section: Course and Prognosismentioning

confidence: 99%

“…When parent report is used, the prevalence increases to 46% [28]. The [30] study reported that 1 in 3 childhood ADHD still met DSM-IV criteria when aged 18-to 44-years [30]. In [32] study 40% of 18-to 20-year-old "grown up" ADHD patients met full criteria for ADHD, but 90% had at least five symptoms of ADHD [32].…”

Section: Epidemiologymentioning

confidence: 99%

ADHD Through Different Developmental Stages

Kumperščak¹

2013

Attention Deficit Hyperactivity Disorder in Children and Adolescents

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Patterns and Predictors of Attention-Deficit/Hyperactivity Disorder Persistence into Adulthood: Results from the National Comorbidity Survey Replication

Abstract: No modifiable risk factors were found for adult persistence of ADHD. Further research, ideally based on prospective general population samples, is needed to search for modifiable determinants of adult persistence of ADHD.

Cited by 560 publications

References 62 publications

Exploration of 19 serotoninergic candidate genes in adults and children with attention-deficit/hyperactivity disorder identifies association for 5HT2A, DDC and MAOB

Exploration of 19 serotoninergic candidate genes in adults and children with attention-deficit/hyperactivity disorder identifies association for 5HT2A, DDC and MAOB

Transtorno do déficit de atenção e hiperatividade: contribuição diagnóstica de avaliação computadorizada de atenção visual

ADHD Through Different Developmental Stages

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