Patterns and determinants of cardiovascular drug utilization in coronary care unit patients of a tertiary care hospital

George, Jesso; Devi, Padmini; Kamath, Deepak; Anthony, Naveen; Kunnoor, Nitin S.; Sanil, Sandra S.

doi:10.1016/j.jcdr.2013.12.001

Cited by 11 publications

(18 citation statements)

References 28 publications

(24 reference statements)

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“…For 2015, of the total 540 patients, 168 patients (31%) were hypertensive, 82 patients (15%) were diabetic and 112 patients (21%) were found to have both HTN and DM, while 178 patients (33%) neither had HTN or DM associated with IHD, and for 2013, of the total 410 patients, 104 patients (25%) were hypertensive, 65 patients (16%) were diabetic and 82 patients (20%) were found to have both HTN and DM, while 159 patients (39%) neither had HTN or DM associated with IHD. This result is similar to a study done by George et al 20 Prevalence of hypertension in India, for the last three decades, has increased by about 30 and 10 times among urban and rural residents respectively. 23 Hypertension and diabetes mellitus are major and modifiable risk factors which when controlled can significantly reduce IHDs morbidity and mortality.…”

Section: Discussionsupporting

confidence: 92%

“…Polypharmacy may be justified as this was a tertiary care setting where the majority of patients were hospitalized with multiple co-morbidities. This result was similar to the finding by George et al 20 Duration of stay at the hospital varied from patient to patient and their associated conditions. In our study for the year 2015, the average number of days spent by the patients in the hospital was 3.51 and that in 2013 was 3.59 days.…”

Section: Discussionsupporting

confidence: 91%

“…For 2013, highest number of patients (both males and females included) were in the age group of 51-60 years (161 patients, 39.27%), followed by the age group of 61-70 years (99 patients, 24.15%), and mean age group was around 56.93 years. This result is similar to a study done by George et al 20 Early age at onset of IHD has been documented as one of the unique barriers to the optimal management of IHD in India. 21 Polypharmacy has been observed in our study.…”

Section: Discussionsupporting

confidence: 91%

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Drug utilization study in ischaemic heart disease in a tertiary care hospital, Mangalore, India

Zachariah

Subramanyam

Pooja

et al. 2017

Int J Basic Clin Pharmacol

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Background: The study of drug utilization is a component of a medical audit and periodic evaluation need to be done to enable suitable modifications in prescription of drugs to increase the therapeutic benefit and decrease the adverse effects. When new drugs are used additional information on safety and efficacy may be generated. Ischaemic heart disease (IHD) is a condition in which there is an inadequate supply of blood and oxygen to a portion of the myocardium. Medications for IHD include anti-platelet therapy, nitrates, statins, ACE inhibitors, beta blockers, CCB’s, diuretics.Methods: The study was carried out at cardiology department of K. S. Hegde Charitable Hospital for a period of one year from January 2015, and relevant retrospective data were also collected from hospital records for period pertaining to one year from 1/1/2013.Results: We assessed discharge summaries of 950 patients and found that majority of patients were males than females. The highest number of patients were in the age group of 51-60 years. Polypharmacy has been observed in our study. The average number of days spent by the patients in the hospital was 3.5 days. None of the drugs were prescribed using generic names, all the drugs (100%) were prescribed in brand names only. Common co-morbidities associated with IHD were hypertension and diabetes. Most commonly prescribed drugs for IHD were Aspirin, followed by Atorvastatin, Clopidogrel, and Nitrates.Conclusions: In our study, on analysing the drug prescription data it was observed that there was no statistically significant change in drug utilization between the two years.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Drug utilization study in ischaemic heart disease in a tertiary care hospital, Mangalore, India

Zachariah

Subramanyam

Pooja

et al. 2017

Int J Basic Clin Pharmacol

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“…Polypharmacy may be justified as this was a CCU setup where the majority of patients were hospitalized with multiple co morbidities. This result was similar to the finding by George et al 15 Comparing 2010 with 2016 shows average number of drugs per prescription is increased in prospective study.…”

Section: Discussionsupporting

confidence: 91%

Periodic evaluation of drug utilization in intensive coronary care unit patients in a tertiary care hospital

Sharma

Holla

Subramanyam

et al. 2018

Int J Basic Clin Pharmacol

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Background: A wide and gradual variation exists periodically in the patterns of pharmacotherapy among patients admitted with CVDs in CCU. Periodic evaluation of drug utilization in the CCU is necessary for optimization of health care system, proper use of resources and making prescription policy.Methods: It was retrospective and prospective study. Study was carried out at Tertiary care hospital in Mangalore. Retrospective study period was from 1/07/2010 till 31/12/2010 and Prospective study duration was from 1/01/2016 till 30/06/2016. Patients from CCU were participants of this study.Results: Data of total 278 patients were taken, out of which 138 patients from 2010 and 140 patients in 2016 were analyzed respectively and were compared among drug therapy for IHD - Nitrates, dual antiplatelet therapy (aspirin and clopidogrel), dyslipidemic drugs and beta blockers remain drug of choice in both retrospective and prospective study. But, anticoagulant (heparin/ LMWH) use increased in prospective studies. In Heart failure - nitrates, antiplatelet, dyslipidemic drugs followed by inotropes and diuretics was used in both study. Cardiomyopathy was managed with diuretics, ACEIs, and nitrates in both retrospective and prospective study.Conclusions: In conclusion, predominance of male gender and poly-pharmacy were observed. However, it has identified areas to further rationalize and optimize patterns of polypharmacy and evidence based use of medications like beta blockers, anticoagulants/antiplatelet agents and antiarrythmisc. The results on the major determinants of cardiovascular drug use in CCU matched with the existing indications and cautions for use with each drug class.

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“…Among other findings, the researchers concluded that antiplatelets were an integral component of treatment of certain CVDs. 8 The current study also indicated a high and significant usage of antiplatelet medications.…”

Section: Discussionsupporting

confidence: 56%

Retrospective Drug Utilization of Cardiovascular Drugs in A Tertiary Healthcare Setting in Malaysia

Yap¹,

Aaseer²,

Ng³

2018

JYP

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Objective:The general objective of this study was to analyse the utilization patterns of cardiovascular drugs among a sample of patients in a tertiary healthcare setting during the preceding two years. Methodology: This study design was exploratory, descriptive and retrospective. Data were extracted from the case sheets pertaining to patients who had been admitted to the study site and administered CV drugs during the preceding two years, into customized data collection format. A total of 100 patient data were obtained, based on the inclusion criteria. The data collected were then analyzed by SPSS v22. Results: A total of 29 males (28.4%) and 73 females (71.6%) data were analysed. The majority of the patients were in the age range 50-55 years. Among the ethnic groups, the Malays (72.5%) were the highest, followed by Indians (14.7%) and the Chinese (11.8%). The co-morbidities observed among the sample are depicted in Table 1 with p < 0.001 (Chi-square test). It was noted that the combination of HTN +DM was the most observed (18.6%). Among the CV medications, statins (54.9%), antiplatelets (39.2%), anticoagulants (26.5%) and beta-blockers (33.3%) were more commonly used for these patients. Conclusion: The usage of all these medications was in accordance with the national guidelines in Malaysia. The mean CV drug count was 3.16, which though optimal might be indicative of potential non-compliance among patients.This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Patterns and determinants of cardiovascular drug utilization in coronary care unit patients of a tertiary care hospital

Cited by 11 publications

References 28 publications

Drug utilization study in ischaemic heart disease in a tertiary care hospital, Mangalore, India

Drug utilization study in ischaemic heart disease in a tertiary care hospital, Mangalore, India

Periodic evaluation of drug utilization in intensive coronary care unit patients in a tertiary care hospital

Retrospective Drug Utilization of Cardiovascular Drugs in A Tertiary Healthcare Setting in Malaysia

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