Patterning of the Embryonic Avian Midbrain after Experimental Inversions: A Polarizing Activity from the Isthmus

Marı́n, Faustino; Puelles, Luis

doi:10.1006/dbio.1994.1120

Cited by 193 publications

(103 citation statements)

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“…This cdh1 distribution was very similar to the wnt1 expression pattern at the same stage (F). Scale bars ϭ 200 m. (Brand et al, 1996;Joyner, 1996;Marin and Puelles, 1994;Martinez et al, 1991). E-cadherin adhesion may help maintain the integrity of this organizing center.…”

Section: Discussion Cdh1 Expression During Early Embryogenesis Indicamentioning

confidence: 99%

“…Expression was found in the telencephalon, diencephalon, and rhombencephalon and was prominent at the MHB (Fig. 3A-C), a structure that acts as an organizer for development of the adjacent optic tectum, tegmentum, and cerebellum (Martinez et al, 1991;Marin and Puelles, 1994;Brand et al, 1996).…”

Section: Zebrafish E-cadherin Cdna Cloning and Expression In Early Dementioning

confidence: 98%

“…In zebrafish, mutations in the Pax2.1 gene (no isthmus or noi) and in the Fgf8 gene (acerebellar or ace) disrupt MHB development (Brand et al, 1996). When formed, the MHB displays organizer activities (Marin and Puelles, 1994;Martinez et al, 1991), generating signals that induce the development of cerebellum, tegmentum, and optic tectum. wnt1 mutations in mouse disrupt MHB development (McMahon and Bradley, 1990;McMahon et al, 1992;Thomas and Capecchi, 1990;Thomas et al, 1991), and wnt1 distributions suggest a similar role in MHB formation in zebrafish (Kelly and Moon, 1995), but mutations in the zebrafish wnt1 gene have not been identified.…”

Section: Introductionmentioning

confidence: 99%

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Zebrafish E‐cadherin: Expression during early embryogenesis and regulation during brain development

Babb

Barnett

Doedens

et al. 2001

Developmental Dynamics

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ABSTRACT:Zebrafish E-cadherin (cdh1) cell adhesion molecule cDNAs were cloned. We investigated spatial and temporal expression of cdh1 during early embryogenesis. Expression was observed in blastomeres, the anterior mesoderm during gastrulation, and developing epithelial structures. In the developing nervous system, cdh1 was detected at the pharyngula stage (24 hpf) in the midbrain-hindbrain boundary (MHB). Developmental regulation of MHB formation involves wnt1 and pax2.1. wnt1 expression preceded cdh1 expression during MHB formation, and cdh1 expression in the MHB was dependent on normal development of this structure.

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Section: Discussion Cdh1 Expression During Early Embryogenesis Indicamentioning

confidence: 99%

Section: Zebrafish E-cadherin Cdna Cloning and Expression In Early Dementioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Zebrafish E‐cadherin: Expression during early embryogenesis and regulation during brain development

Babb

Barnett

Doedens

et al. 2001

Developmental Dynamics

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“…The IsO was first identified through transplantation experiments, in which MHB tissue grafts were transplanted to more rostral or caudal neural locations, resulting in the induction of mesencephalic-metencephalic fate in the host tissue surrounding the graft (Martinez et al, 1991;Marin and Puelles, 1994). This organizer-like activity on the surrounding neural tissue is thought to be mediated by fibroblast growth factor 8 (Fgf8) and Wnt1 proteins which are secreted from the MHB tissue.…”

Section: Functional Conservation Of Otd/otx Genes In Embryonic Brain mentioning

confidence: 99%

Insights into the urbilaterian brain: conserved genetic patterning mechanisms in insect and vertebrate brain development

2005

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Recent molecular genetic analyses of Drosophila melanogaster and mouse central nervous system (CNS) development revealed strikingly similar genetic patterning mechanisms in the formation of the insect and vertebrate brain. Thus, in both insects and vertebrates, the correct regionalization and neuronal identity of the anterior brain anlage is controlled by the cephalic gap genes otd/Otx and ems/Emx, whereas members of the Hox genes are involved in patterning of the posterior brain. A third intermediate domain on the anteroposterior axis of the vertebrate and insect brain is characterized by the expression of the Pax2/5/8 orthologues, suggesting that the tripartite ground plans of the protostome and deuterostome brains share a common evolutionary origin. Furthermore, cross-phylum rescue experiments demonstrate that insect and mammalian members of the otd/Otx and ems/Emx gene families can functionally replace each other in embryonic brain patterning. Homologous genes involved in dorsoventral regionalization of the CNS in vertebrates and insects show remarkably similar patterning and orientation with respect to the neurogenic region (ventral in insects and dorsal in vertebrates). This supports the notion that a dorsoventral body axis inversion occurred after the separation of protostome and deuterostome lineages in evolution. Taken together, these findings demonstrate conserved genetic patterning mechanisms in insect and vertebrate brain development and suggest a monophyletic origin of the brain in protostome and deuterostome bilaterians.

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“…Brain regionalization, which is an important step for brain development, involves the action of a variety of transcription factors such as Krox20, Otx2, Pax2 and Eng2 (Joyner and Guillemot, 1994). In addition, the midhindbrain region has been suggested to be an organizing center for midbrain patterning and induction (Marin and Puelles, 1994) and its boundary (MHB) is important in restricting cell lineage 3. Phenotypes of cops6 morphants.…”

Section: Cops6 Is Expressed Throughout the Body During Early Zebrafismentioning

confidence: 99%

The deubiquitylating enzyme, Cops6, regulates different developmental processes during early zebrafish embryogenesis

Tse¹,

You²,

Ho³

et al. 2011

Int. J. Dev. Biol.

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Zebrafish cops6 encodes a putative deubiquitylating enzyme (DUB) that belongs to the JAMM family. It consists of 297 amino acids and includes the Mov34/MPN/PAD-1 (PF01398) domain. Ubiquitylation is involved in many cellular processes and deconjugation of ubiquitinmodified substrates is important to maintain a sufficient amount of free ubiquitin in the cell. Here, we report our findings regarding the general function of the cops6 gene, as a continuation of our previous studies involving DUB knockdown screening. We have found that cops6 plays different roles in early embryonic development in the zebrafish, including dorsoventral patterning, convergent extension movement and brain formation. In addition, our findings indicate that cops6 plays an anti-apoptotic role during segmentation. Overall, the present study that consolidates our previous work on zebrafish DUB genes, corroborates the hypothesis of multi-functional roles for DUB genes during development.

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Patterning of the Embryonic Avian Midbrain after Experimental Inversions: A Polarizing Activity from the Isthmus

Cited by 193 publications

References 0 publications

Zebrafish E‐cadherin: Expression during early embryogenesis and regulation during brain development

Zebrafish E‐cadherin: Expression during early embryogenesis and regulation during brain development

Insights into the urbilaterian brain: conserved genetic patterning mechanisms in insect and vertebrate brain development

The deubiquitylating enzyme, Cops6, regulates different developmental processes during early zebrafish embryogenesis

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