Patterned Poly(dopamine) Films for Enhanced Cell Adhesion

Chen, Xi; Cortez‐Jugo, Christina; Choi, Gwan Hyun; Björnmalm, Mattias; Dai, Yunlu; Yoo, Pil J.; Caruso, Frank

doi:10.1021/acs.bioconjchem.6b00544

Cited by 20 publications

(20 citation statements)

References 28 publications

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“…[7,8,9]. The presence of functional groups such as catechol, amine and imine groups, and its high biocompatibility renders PDA an ideal material for biomedical applications [1], sensing applications (e.g., for bioaffinity sensing [10], DNA sensing [11], for intracellular pH sensing [12]), and as substrate for cell adhesion [13]. Deposition of PDA films can be achieved via a simple one step dipping procedure in slightly basic aqueous dopamine solutions (>pH 7.4) through oxidation and subsequent self-polymerization in the presence of oxygen [6] or other oxidants such as reactive oxygen species (ROS) generated via UV radiation [14] or Cu 2+ /H 2 O 2 [14] in phosphate buffered, TRIS buffered or hydrogencarbonate-buffered solutions.…”

Section: Introductionmentioning

confidence: 99%

Micro-Structured Polydopamine Films via Pulsed Electrochemical Deposition

et al. 2019

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Polydopamine (PDA) films are interesting as smart functional materials, and their controlled structured formation plays a significant role in a wide range of applications ranging from cell adhesion to sensing and catalysis. A pulsed deposition technique is reported for micro-structuring polydopamine films using scanning electrochemical microscopy (SECM) in direct mode. Thereby, precise and reproducible film thicknesses of the deposited spots could be achieved ranging from 5.9 +/− 0.48 nm (1 pulse cycle) to 75.4 nm +/− 2.5 nm for 90 pulse cycles. The obtained morphology is different in comparison to films deposited via cyclic voltammetry or films formed by autooxidation showing a cracked blister-like structure for high pulse cycle numbers. The obtained polydopamine spots were investigated in respect to their electrochemical properties using SECM approach curves. Quantitative kinetic data in dependence of the film thickness, the substrate potential, and the used redox species were obtained.

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Section: Introductionmentioning

confidence: 99%

Micro-Structured Polydopamine Films via Pulsed Electrochemical Deposition

et al. 2019

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“…Differentiation of stem cells has been obtained with LbL coatings [101]. Adhesion of cells can be promoted either by patterning [102], chemically patterning the LbL sources [103] or by adjusting mechanical properties [104]. Adjusting the mechanical properties, which can be done by addition of gold nanoparticles on the surface, allows not only for controlling cell adhesion, but also to controllably embed and pattern particle [105,106].…”

Section: Assembly Of Polymers Into Coatings and Films: Hydrogels Lblmentioning

confidence: 99%

Polymer- and Hybrid-Based Biomaterials for Interstitial, Connective, Vascular, Nerve, Visceral and Musculoskeletal Tissue Engineering

2020

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In this review, materials based on polymers and hybrids possessing both organic and inorganic contents for repairing or facilitating cell growth in tissue engineering are discussed. Pure polymer based biomaterials are predominantly used to target soft tissues. Stipulated by possibilities of tuning the composition and concentration of their inorganic content, hybrid materials allow to mimic properties of various types of harder tissues. That leads to the concept of "one-matches-all" referring to materials possessing the same polymeric base, but different inorganic content to enable tissue growth and repair, proliferation of cells, and the formation of the ECM (extra cellular matrix). Furthermore, adding drug delivery carriers to coatings and scaffolds designed with such materials brings additional functionality by encapsulating active molecules, antibacterial agents, and growth factors. We discuss here materials and methods of their assembly from a general perspective together with their applications in various tissue engineering sub-areas: interstitial, connective, vascular, nervous, visceral and musculoskeletal tissues. The overall aims of this review are two-fold: (a) to describe the needs and opportunities in the field of bio-medicine, which should be useful for material scientists, and (b) to present capabilities and resources available in the area of materials, which should be of interest for biologists and medical doctors.Polymers 2020, 12, 620 2 of 30 allows to tailor functionalize the coatings, where their responsiveness to external stimuli is one of their biggest advantages.Polymers stand out as a special class of materials due to the flexibility of design of their blocks and various functionalities, which is brought by their versatile assembly or by introducing additional side-groups or blocks, in the case of block-co-polymers. In this regard, both synthetic and biocompatible polymers are available, and polymer engineering represents a growing area tailoring the needs often driven by applications. With all advantages and the flexibility of the design, there is one significant weakness of polymers-the softness. In regard with tissue engineering, that translates to the fact that some materials can match predominantly soft tissue, but it is difficult to tune mechanical properties of polymers to match the hardness of bones, tendons, etc. And since mechanical properties of materials affect and even drive cell and tissue growth, enhancement of mechanical properties of polymers and biomaterials is essential. Chemical crosslinking can be applied to address these challenges, but that solves problems only partially.To solve these challenges the so-called hybrid materials [6] are used, which possess both inorganic and organic contents. Increasingly, hybrid materials are used in designing the extracellular matrix. The hybrid matrix design for various tissue engineering applications should meet bio-medical requirements. On the one hand, it needs to be biocompatible and biodegradable, which is achieved through the po...

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“…In terms of tissue engineering, PDA has been previously proven to be beneficial for cell attachment, and the utilization of PDA coatings in this field has been reported. For instance, PDA and arginylglycylaspartic acid were deposited onto a 3D graphene framework via the layer‐by‐layer method to prepare porous scaffolds for the adhesion and expression of neural cells both in vitro and in vivo .…”

Section: Pda‐coating Filmsmentioning

confidence: 99%

Current Advances in the Utilization of Polydopamine Nanostructures in Biomedical Therapy

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Batul

Bhave

et al. 2019

Biotechnology Journal

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Since the first time mussel‐inspired polymer polydopamine (PDA) was discovered, it has gained enormous attention from numerous scientists, especially those working in the field of drug delivery and bacterial and tumor treatment, due to its distinctive properties, such as surface chemistry, biocompatibility, capability to adhere to any surface, and excellent photothermal conversion. Studies using PDA in various types of structures for therapeutic purposes have been carried out extensively in recent years. Considering the rapid development in the area, this review aims to cover and highlight the latest achievements (from 2016 to present) with respect to PDA‐based materials for therapeutic purposes. A description of the diverse structures of PDA and its formation strategy, including colloidal particles, hollow structures, and coating films, are discussed. In addition, the main focus of this review is on the therapeutic applications of these PDA nanostructures.

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Patterned Poly(dopamine) Films for Enhanced Cell Adhesion

Cited by 20 publications

References 28 publications

Micro-Structured Polydopamine Films via Pulsed Electrochemical Deposition

Micro-Structured Polydopamine Films via Pulsed Electrochemical Deposition

Polymer- and Hybrid-Based Biomaterials for Interstitial, Connective, Vascular, Nerve, Visceral and Musculoskeletal Tissue Engineering

Current Advances in the Utilization of Polydopamine Nanostructures in Biomedical Therapy

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