Pattern, Stage, and Time of Recurrent Colorectal Cancer After Curative Surgery

Guraya, Salman Yousuf

doi:10.1016/j.clcc.2019.01.003

Cited by 92 publications

(66 citation statements)

References 50 publications

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“…The global burden of CRC is expected to increase by 60% to more than 2.2 million new cases and 1.1 million deaths by 2030 [ 1 ]. Despite the standardization of surgical procedures (total mesorectal excision and complete mesocolic excision) and the contributory effect of neoadjuvant and adjuvant therapies on survival, recurrence occurs in 30%–50% of CRC cases [ 2 ]. There are numerous factors affecting survival in CRC that could be divided into 2 main groups: patient characteristics (performance status, age, and sex) and tumor characteristics (TNM stage, biomarkers, and gene mutations).…”

Section: Introductionmentioning

confidence: 99%

The prognostic significance of serum lactate dehydrogenase-to-albumin ratio in colorectal cancer

2020

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Colorectal cancer (CRC) is the third most common cancer and fourth leading cause of cancer-associated mortality worldwide. The global burden of CRC is expected to increase by 60% to more than 2.2 million new cases and 1.1 million deaths by 2030 [1]. Despite the standardization of surgical procedures (total mesorectal excision and complete mesocolic excision) and the contributory effect of neoadjuvant and adjuvant therapies on survival, recurrence occurs in 30%-50% of CRC cases [2]. There are numerous factors affecting survival in CRC that could be divided into 2 main groups: patient characteristics (performance status, age, and sex) and tumor characteristics (TNM stage, biomarkers, and gene mutations). However, it is well known that the survival time can differ even for patients with the same characteristics and the same disease stage at diagnosis. LDH and albumin are significant markers of systemic inflammation and have been shown to play a key role in promoting cancer

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Section: Introductionmentioning

confidence: 99%

The prognostic significance of serum lactate dehydrogenase-to-albumin ratio in colorectal cancer

2020

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“…Currently, the main treatments for CRC surgery, radiotherapy and chemotherapy. However, one-third of patients exhibit recurrent issues following radical surgery and distant metastasis (3,4). Furthermore, the radiation dose is difficult to control during radiotherapy and the identification of the location of lesions in patients with CRC is required for an accurate dose to be administered (5).…”

Section: Introductionmentioning

confidence: 99%

Function and mechanisms of microRNA‑20a in colorectal cancer (Review)

et al. 2020

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Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer-associated mortality worldwide. CRC currently has no specific biomarkers to promote its diagnosis and treatment and the underlying mechanisms regulating its pathogenesis have not yet been determined. MicroRNAs (miRs) are small, non-coding RNAs that exhibit regulatory functions and have been demonstrated to serve a crucial role in the post-transcriptional regulatory processes of gene expression that is associated with cell physiology and disease progression. Recently, abnormal miR-20a expression has been identified in a number of cancers types and this has become a novel focus within cancer research. High levels of miR-20a expression have been identified in CRC tissues, serum and plasma. In a recent study, miR-20a was indicated to be present in feces and to exhibit a high sensitivity to CRC. Therefore, miR-20a may be used as a marker for CRC and an indicator that can prevent the invasive examination of patients with this disease. Changes in the expression of miR-20a during chemotherapy can be used as a biomarker for monitoring resistance to treatment. In conclusion, miR-20a exhibits the potential for clinical application as a novel diagnostic biomarker and therapeutic target for use in patients with CRC. The present study focused on the role and mechanisms of miR-20a in CRC. Contents 1. Introduction 2. microRNA-20a overview 3. The mechanism of miR-20a in CRC 4. miR-20a can be used as a diagnostic marker in CRC 5. miR-20a may be used as a monitoring indicator during chemotherapy 6. Conclusion and prospects

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“…Colon cancer is the third‐most frequent cancer worldwide . Although great treatment advancements have been achieved, the high frequency of recurrence in patients with colon cancer remains the major problem in clinical practice . Effective treatments for the metastasis of colon cancer cells are limited.…”

Section: Introductionmentioning

confidence: 99%

LINC00961 inhibits the migration and invasion of colon cancer cells by sponging miR‐223‐3p and targeting SOX11

Dai

Zhang

et al. 2020

Cancer Medicine

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Long noncoding RNAs play essential roles in colon cancer tumorigenesis. This study aimed to explore the potential function and molecular mechanisms of LINC00961 in colon cancer. qPCR results showed that LINC00961 was downregulated in colon cancer cells and tissues. Functional assays demonstrated that LINC00961 suppressed the migration and invasion of colon cancer cells in vitro. LINC00961 functioned as an endogenous sponge for miR‐223‐3p in colon cancer cells. SOX11 was confirmed as a target gene of miR‐223‐3p. The effect of miR‐223‐3p on colon cancer cells was then investigated. MiR‐223‐3p inhibition enhanced their migration and invasion. The effect of SOX11 on colon cancer cells was studied. SOX11 overexpression inhibited the invasion of colon cancer cells. LINC00961 acted as an anti‐oncogene and upregulated SOX11 expression by functioning as a miR‐223‐3p sponge. This research revealed the molecular mechanism of LINC00961 in colon cancer. LINC00961 might act as a potential diagnostic biomarker and therapeutic target for further clinical treatments.

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Pattern, Stage, and Time of Recurrent Colorectal Cancer After Curative Surgery

Cited by 92 publications

References 50 publications

The prognostic significance of serum lactate dehydrogenase-to-albumin ratio in colorectal cancer

The prognostic significance of serum lactate dehydrogenase-to-albumin ratio in colorectal cancer

Function and mechanisms of microRNA‑20a in colorectal cancer (Review)

LINC00961 inhibits the migration and invasion of colon cancer cells by sponging miR‐223‐3p and targeting SOX11

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