“…Age-related changes in the electrical responses of the retina and cortex are an important consideration when analysing clinical data. Various workers have separately investigated the effect of age on the normal ERG to flash stimulation (Karpe et al, 1950;Zetterstrom, 1956;Zeidler, 1959;Straub, 1961 ;Peterson, 1968;Weleber, 1981 ;Martin and Heckenlively, 1982) and on the flash VEP (Kooi and Bagchi, 1964;Copenhaver and Perry, 1964;Dustman and Beck, 1966;1969, Buchsbaum et al, 1974Dustman et al, 1977;Cosi et al, 1982) and the pattern reversal VEP (Asselman et al, 1975;Celesia and Daly, 1977;Allison et al, 1979Allison et al, , 1983Stockard et al, 1979;Shaw and Cant, 1981;Snyder et al, 1981;Sokol et al, 1981;Halliday et al, 1982). There are few studies on age-related changes in VEPs evoked by pattern onset-offset stimulation, which is a subject of considerable interest (de Vries-Khoe and Spekreijse, 1982;Spekreijse et al, 1973;Jeffreys, 1977).…”