Pattern of pericardial diseases in HIV-positive patients at University College Hospital, Ibadan, Nigeria

Abubakar, U.; Adeoye, Peter Oladapo; Adebo, O A; Adegboye, V O; Kesieme, Emeka B.; Okonta, Kelechi E.

doi:10.4102/sajhivmed.v12i2.194

Cited by 4 publications

(4 citation statements)

References 13 publications

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“…This study shows a relatively high rate of HIV infection (32/83, 38.6%) among patients with constrictive pericarditis compared to the 14.6% reported by Mutyaba et al 2 in a recent South African study, but less than the 12/19 (63%) reported by Abubaker and colleagues 17 in a Nigerian study. These data for developing countries are in contrast to the very low rate reported by Gopaldas et al 18 in the USA, who found only 10 HIV-positive Data presented as mean ± standard deviation for continuous variables and n (%) for categorical variables.…”

Section: Discussioncontrasting

confidence: 48%

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The effects of HIV/AIDS on the clinical profile and outcomes post pericardiectomy of patients with constrictive pericarditis: a retrospective review

Naidoo

Laurence

Sartorius

et al. 2019

CVJA

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Objective: The clinical profile and surgical outcomes of patients with constrictive pericarditis were compared in HIV-positive and-negative individuals. Methods: This study was a retrospective analysis of patients diagnosed with constrictive pericarditis at Inkosi Albert Luthuli Central Hospital, Durban, over a 10-year period (2004-2014). Results: Of 83 patients with constrictive pericarditis, 32 (38.1%) were HIV positive. Except for pericardial calcification, which was more common in HIV-negative subjects (n = 15, 29.4% vs n = 2, 6.3%; p = 0.011), the clinical profile was similar in the two groups. Fourteen patients died preoperatively (16.9%) and three died peri-operatively (5.8%). On multivariable analysis, age (OR 1.17; 95% CI: 1.03-1.34; p = 0.02), serum albumin level (OR 0.63; 95% CI: 0.43-0.92; p = 0.016), gamma glutamyl transferase level (OR 0.97; 95% CI: 0.94-0.1.0; p = 0.034) and pulmonary artery pressure (OR 1.49; 95% CI: 1.07-2.08; p = 0.018) emerged as independent predictors of pre-operative mortality rate. Peri-operative complications occurred more frequently in HIV-positive patients [9 (45%) vs 6 (17.6%); p = 0.030]. Conclusions: Without surgery, tuberculous constrictive pericarditis was associated with a high mortality rate. Although peri-operative complications occurred more frequently, surgery was not associated with increased mortality rates in HIV-positive subjects.

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Section: Discussioncontrasting

confidence: 48%

“…2 Recent data suggest that co-existing HIV infection may modify the clinical manifestations and natural history of tuberculous pericarditis and resultant constriction. 17,18 Our study was designed to evaluate the clinical profile and surgical outcomes of HIV-positive and -negative patients with constrictive pericarditis.…”

mentioning

confidence: 99%

The effects of HIV/AIDS on the clinical profile and outcomes post pericardiectomy of patients with constrictive pericarditis: a retrospective review

Naidoo

Laurence

Sartorius

et al. 2019

CVJA

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“…Two of our patient were HIV positive and they presented with massive effusion and were on antiretroviral and anti-tuberculous drugs at the time of presentation. The association between massive effusion in patients with tuberculosis and HIV infection has been reported [24][25][26][27].…”

Section: Discussionmentioning

confidence: 99%

Subxiphoid Tube Pericardiostomy in the Management of Pericardial Effusion: Our Experience

Umar¹,

Ismail²,

Sani³

et al. 2019

IJCTS

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Introduction -There is minimal amount of fluid within the two layers of the pericardium. This serves to lubricate the layers preventing friction. Various disease processes can lead to increase in the amount of this fluid which cause haemodynamic compromise these patients. Various methods have been used to drain this fluid. We report our experience with subxiphoid tube pericardiotomy in the drainage of pericardial effusion. Material and Method -we reviewed case files of 30 patients that presented to us with pericardial effusion over a six-year period. Results -There were 19 males (63.3%) and 11 females (36.7%). Age range is between 2 yrs and 65 years with a mean of 27.3 yrs. Adult age group accounted for 25 (83.3%) while paediatric age group was 5 (16.7%). Predominant symptom was dyspnea and all patients had subxiphoid tube pericardiostomy for drainage. Majority of our patients (80%) had tuberculosis as the cause of their effusion. Mortality was 3 (10%) following the drainage but cause of death was progression of their disease. The was recurrence in one patient who had malignant effusion and was subsequently treated with pericardial window but later lost to follow up. Conclusion -Subxiphoid tube pericardiostomy still remains the main stay in the management of massive tuberculous pericardial effusion in our environment as it provides the opportunity to drain the fluid and take adequate fluid samples and tissue for diagnosis. Recurrence rate is also low.

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“…Interestingly, a subset of pericardial disease known as effusive-constrictive pericarditis was stated as deserving a closer attention as treatment was challenging [7]. Also, one of the important causes of pericardial diseases resulting in HF in HIV-AIDS patients, that is amenable to surgery, is pericardial effusion [8]. Thus the duo of tuberculosis and HIV infections which are common in the sub-region, have made the condition of pericardial diseases common [9] [10].…”

Section: Epidemiologymentioning

confidence: 99%

Epidemiology and Pathophysiology of Acquired Heart Failures Amenable to Surgical Interventions in the Sub-Saharan Africa

Okonta¹

2014

WJCS

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Heart failure (HF) is an important cause of morbidity and mortality in sub-Saharan Africa and indeed worldwide. The management of this condition has largely been thought to be within the domain of the Physician with the Surgeon having little or no role to play. The commonest cause of HF that may require surgical intervention is rheumatic valvular heart disease especially in the young age group while ischaemic heart disease still remains at the low rung of the ladder and interestingly, hypertrophic cardiomyopathy is becoming common. Most of the literatures reviewed failed to identify pericardial diseases, though it ranked topmost in the face of tuberculosis and HIV infections in the sub-region, and the other non-cardiac structures as important causes of HF which is amenable to surgical intervention. Equally, what have not been clearly identified are the surgical aspects; indeed its sub-classifications into heart and non-heart causes have hitherto not been documented. Even though these lists from this review are not exhaustive of the numerous unidentified causes of surgical HF, this would act as stimulus for further and extensive documentation of guideline for the recognition of these sub-classifications of HF amenable to surgery.

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Pattern of pericardial diseases in HIV-positive patients at University College Hospital, Ibadan, Nigeria

Cited by 4 publications

References 13 publications

The effects of HIV/AIDS on the clinical profile and outcomes post pericardiectomy of patients with constrictive pericarditis: a retrospective review

The effects of HIV/AIDS on the clinical profile and outcomes post pericardiectomy of patients with constrictive pericarditis: a retrospective review

Subxiphoid Tube Pericardiostomy in the Management of Pericardial Effusion: Our Experience

Epidemiology and Pathophysiology of Acquired Heart Failures Amenable to Surgical Interventions in the Sub-Saharan Africa

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