Pattern of long-term complications in Sudanese insulin-treated diabetic patients

Elbagir, Murtada; Eltom, Mohamed; Mahadi, Elfatih O.; Berne, Christian

doi:10.1016/0168-8227(95)01146-3

Cited by 50 publications

(39 citation statements)

References 16 publications

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“…The prevalence of neuropathy and peripheral vascular disease in Sudan was well documented in the literature. For instance, the prevalence of peripheral neuropathy in Sudan in association with diabetes showed progressive increase over the last 2 decades, as the prevalence in 1989 was 28.1%, in 1991 was 31.5%, 1995 it was 37% and in 2000 it was 66% (17)(18)(19)(20). Importantly, this was attributed to prolonged duration of diabetes and poor glycemic control (17).…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have shown association between diabetic foot and hypertension, albuminuria, retinopathy, neuropathy, HbA1c, cholesterol, HDL, LDL and triglyceride (8,(11)(12)(13)(14)(15)(16). Peripheral vascular disease is another important contributor in pathogenesis of diabetic foot, and prevalence of peripheral vascular disease in Sudan in 1989 was estimated to be 6.2% and this increased to 10% in 1995 (18,20). Due to increase in urbanization across Africa there is an increase in prevalence of peripheral vascular disease.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of diabetic foot ulceration and associated risk factors: an old and still major public health problem in Khartoum, Sudan?

et al. 2017

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Background: Diabetic foot ulceration (DFU) is a major health problem across the globe. The objective of this study is to determine the prevalence of DFU and its associated risk factors in Sudanese individuals with diabetes.Methods: Three hundred and ten individuals with type 2 diabetes, who have been on treatment for DM for at least 1 year and volunteered to participate, were enrolled in this study. Participants were interviewed using standardized pretested questionnaire to record medical history, socio-demographic, life style characteristics and presence of DFU.Results: The prevalence of DFU was found to be 18.1% in this cohort (95% CI: 13.78-22.34%). Among different metabolic variants like hypertension, albuminuria, retinopathy, neuropathy, HbA1c, cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL) and triglyceride, only duration of diabetes was significantly associated with DFU (P<0.0018) as shown by logistic regression statistical analysis. Even after adjusting for all other potential risk factors, living with diabetes for more than 10 years is associated with an increase in the diabetic foot probability by 3.16 folds (95% CI: 052-10.48 folds increase), P=0.006.The adjusted effect for living with diabetes for more than 20 years on the diabetic foot complication probability is an increase by 1.73 folds (95% CI: 0.39-4.37 folds increase), P=0.005. However, living with diabetes for more than 5 years had a non-significant adjusted effect on diabetic foot probability.Conclusions: Prevalence of diabetic foot ulcer was 18.1 % and the risk of development of diabetic foot ulcer is increased with duration of diabetes more than 10 years.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prevalence of diabetic foot ulceration and associated risk factors: an old and still major public health problem in Khartoum, Sudan?

et al. 2017

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“…48 In a cross-sectional study in the Sudanese diabetic population, the prevalence of cerebrovascular disease was found to be 5.5%. 36 Among 600 African diabetic subjects from Zambia, Rolfe 49 found 7 with stroke. In a prospective study of 51 hypertensive and 54 normotensive type 2 diabetic Nigerians, strokeassociated deaths occurred in 8 subjects (7.6%), and all the stroke-related deaths occurred in the hypertensive group.…”

Section: Cerebrovascular Diseasesmentioning

confidence: 99%

“…CAD (28%) was the most frequent macrovascular complication of diabetes in Sudanese subjects with diabetes, followed by peripheral vascular diseases (10%) and stroke (5.5%). 36 A dual-arm (retrospective and prospective) study by Kamotho et al 37 in black Kenyans who underwent coronary angiography found diabetes to be the most strongly associated risk factor in the population with angiographically detected CAD. Diabetes was present in 38.5% of this population, and other cardiovascular risk factors considered were not discriminatory for CAD.…”

Section: Coronary Artery Diseasesmentioning

confidence: 99%

Cardiovascular Complications of Diabetes Mellitus in Sub-Saharan Africa

2005

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Background-Cardiovascular disease, the major cause of mortality and morbidity in modern societies, is set to overtake infectious diseases in the developing world as the most common cause of death. The increasing prevalence of major and emerging cardiovascular risk factors accounts for the growing burden of cardiovascular disease in the world. Diabetes in all its forms is one of the main cardiovascular risk factors. Two of 3 diabetic patients will die as a result of cardiovascular complications, and approximately 30% of patients treated in cardiovascular intensive care units have diabetes. Methods and Results-This review on the cardiovascular complications of diabetes in sub-Saharan Africa is a bibliographical MEDLINE search of published data over the past 2 decades. Diabetes-related cardiovascular disease complications are considered to be rare in Africa but are on the rise and are regularly associated with classic cardiovascular risk factors. Coronary heart disease may affect 5% to 8% of type 2 diabetic patients and cardiomyopathy, up to 50% of all patients. Close to 15% of patients with stroke have diabetes, and up to 5% of diabetic patients present with cerebrovascular accidents at diagnosis. Peripheral vascular disease prevalence varies across sites from 4% to 28%. Conclusions-It is obvious that diabetes mellitus and related cardiovascular complications are gaining more importance in sub-Saharan Africa. The relative contribution of putative risk factors is not well defined, and further research is therefore needed.

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“…Due to limited resources, most patients do not receive a satisfactory diabetes care and education, resulting in a low rate of clinic attendance and dietary noncompliance leading to poor glycaemic control, a high prevalence of acute and chronic complications and a low quality of life (Elbagir et al 1995a(Elbagir et al , 1995b(Elbagir et al , 1999Abdelgadir et al 2003).…”

mentioning

confidence: 99%

Health Related Quality of Life and Sense of Coherence in Sudanese Diabetic Subjects with Lower Limb Amputation

Abdelgadir

Shebeika

Eltom³

et al. 2009

Tohoku J. Exp. Med.

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Pattern of long-term complications in Sudanese insulin-treated diabetic patients

Cited by 50 publications

References 16 publications

Prevalence of diabetic foot ulceration and associated risk factors: an old and still major public health problem in Khartoum, Sudan?

Prevalence of diabetic foot ulceration and associated risk factors: an old and still major public health problem in Khartoum, Sudan?

Cardiovascular Complications of Diabetes Mellitus in Sub-Saharan Africa

Health Related Quality of Life and Sense of Coherence in Sudanese Diabetic Subjects with Lower Limb Amputation

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