Pattern of Intraocular Pressure in Epidemic Dropsy in India

Malik, K P S; Dadeya, Subhash; Gupta, Vijay; Sharan, Pratibha; Guliani,; Dhawan, Munish

doi:10.1177/004947550403400313

Cited by 6 publications

(4 citation statements)

References 3 publications

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“…Other visual complications include subconjunctival haemorrhage, superficial retinal haemorrhages, retinal venous dilatation and tortuosity, subhyaloid haemorrhages, macular and papillary oedema and central retinal vein occlusion. Visual field defects are rarely permanent and intraocular pressures usually return to normal values within 12 weeks (Malik, Dadeya, Gupta, Sharan, & Dhawan, ).…”

Section: Clinical Presentation and Pathophysiology Of Epidemic Dropsymentioning

confidence: 99%

Assessing the risk of epidemic dropsy from black salve use

Croaker

King

Pyne

et al. 2018

J of Applied Toxicology

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Epidemic dropsy is a potentially life-threatening condition resulting from the ingestion of argemone oil derived from the seeds of Argemone mexicana Linn. Exposure to argemone oil is usually inadvertent, arising from mustard cooking oil adulteration. Sanguinarine, an alkaloid present in argemone oil, has been postulated as a causative agent with the severity of epidemic dropsy correlating with plasma sanguinarine levels. Cases of epidemic dropsy have also been reported following the topical application of argemone containing massage oil. Black salve, a topical skin cancer therapy also contains sanguinarine, but at significantly higher concentrations than that reported for contaminated massage oil. Although not reported to date, a theoretical risk therefore exists of black salve inducing epidemic dropsy. This literature review explores the presentation and pathophysiology of epidemic dropsy and assesses the risk of it being induced by black salve.

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Section: Clinical Presentation and Pathophysiology Of Epidemic Dropsymentioning

confidence: 99%

Assessing the risk of epidemic dropsy from black salve use

Croaker

King

Pyne

et al. 2018

J of Applied Toxicology

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“…Malik KP etal (2004), in their study, found that the rise of IOP in cases of epidemic dropsy appeared to be a transient phenomenon, and drugs needed to be titrated on a weekly basis. (Malik KP ;etal,2004). Some other investigators have found that in cases of epidemic dropsy, acute visual field defects occur independent of rise of intraocular pressure and more frequently in the early stage of the disease.…”

Section: Discussionmentioning

confidence: 99%

Case Study

Gupta

Verma

Singh

2014

International Journal of User-Driven Healthcare

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Epidemic dropsy is a multi-system disease involving the cardiovascular, hepatic, renal, ocular and other systems. Onset is usually subacute or insidious with watery diarrhea and vomiting. This lasts from a few days to more than a week. Bilaterally symmetrical pitting edema of the lower limbs extending from the ankles up to the scrotum and abdominal wall is a constant feature. It is a toxic disease caused by the unintentional ingestion of Argemone mexicana (prickly yellow poppy) seeds as an adulterant of wheat flour, or more commonly, of cooking oil such as mustard oil. Sanguinarine and dehydrosanguinarine are two major toxic alkaloids of Argemone oil. It is a rare phenomenon for practicing ophthalmologists to observe cases of epidemic dropsy, and the possibility of glaucoma should be kept in mind in cases of epidemic dropsy, when members of same family or village report with raised IOP, pedal edema and history of use of mustard oil for cooking or massage. Glaucoma is hypersecretory in nature; prostaglandin and histamine release may have significant roles in its pathogenesis. The disease has self limiting course but needs good control of intraocular pressure (IOP) medically till it returns to normal and visual field changes have stabilized. Its early diagnosis is very important to prevent grievous complications; hence, all cases should be followed up regularly for IOP measurement and visual field analysis up to 8-12 weeks, because, if ignored, optic atrophy may develop.

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“…The condition has been associated with epidemic dropsy since dropsy patients www.nature.com/scientificreports www.nature.com/scientificreports/ present high IOP levels with normal outflow facility 26 . Visual field defects have been reported but they may reflect edematous effects of the disease 27 , especially since the IOP elevation is transient 28 . While an animal model of aqueous overproduction might not have compelling clinical need, it can still have translational impact by providing an alternative experimental route of understanding IOP-driven mechanisms of glaucoma.…”

Section: Discussionmentioning

confidence: 99%

Experimental glaucoma model with controllable intraocular pressure history

Ficarrotta

Mohamed

Passaglia

2020

Sci Rep

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Glaucoma-like neuropathies can be experimentally induced by disturbing aqueous outflow from the eye, resulting in intraocular pressure (iop) changes that are variable in magnitude and time course and permanent in duration. This study introduces a novel method of glaucoma induction that offers researchers round-the-clock measurement and reversible control of IOP for the first time. One eye of Brown-norway rats was implanted with a cannula tethered to a pressure sensor and aqueous reservoir. IOP was raised 10 mmHg for weeks-to-months in treated animals and unaltered in control animals. Counts of Brn3a-expressing retinal ganglion cells (RGCs) in implanted eyes were indistinguishable from non-implanted eyes in control animals and 15 ± 2%, 23 ± 4%, and 38 ± 4% lower in animals exposed to 2, 4, and 9 weeks of IOP elevation. RGC loss was greater in peripheral retina at 2 weeks and widespread at longer durations. optic nerves also showed progressive degeneration with exposure duration, yet conventional outflow facility of implanted eyes was normal (24.1 ± 2.9 nl/min/mmHg) even after 9-weeks elevation. Hence, this infusion-based glaucoma model exhibits graded neural damage with unimpaired outflow pathways. The model further revealed a potentially-significant finding that outflow properties of rat eyes do not remodel in response to chronic ocular hypertension.

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Pattern of Intraocular Pressure in Epidemic Dropsy in India

Cited by 6 publications

References 3 publications

Assessing the risk of epidemic dropsy from black salve use

Assessing the risk of epidemic dropsy from black salve use

Case Study

Experimental glaucoma model with controllable intraocular pressure history

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