The current study aimed to explicate the effect of preventative pill effect on the lipids levels and lipase activity. The study design included two groups each consists of thirty women; preventative pill group (women who were taking contraceptive pills) and control group (women who were not taking contraceptive pills), their ages ran between (20-40) year. Blood samples were collected for the period from 1/11/2019 to 3/1/2020. Results of this study showed that there was a significant increase in the levels of total cholesterol (TC), Triglycerides (TG), low-density lipoproteins-cholesterol (LDL-C) and very low-density lipoproteins-cholesterol (VLDL-C) in contraceptive pills group compared to control group, while there was a significant decrease in Lipase activity and high-density lipoprotein-cholesterol (HDL-C) level in contraceptive pills group compared with control group.