Pattern of diastolic dysfunction in alcoholic and non-alcoholic cirrhotic portal hypertensive patients with or without ascites in rural population in South India

Sidmal, Prashant S; Bg, Prashanthkumar; Kc, Shekarappa

doi:10.18203/2320-6012.ijrms20150623

Cited by 3 publications

(3 citation statements)

References 28 publications

(39 reference statements)

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“…In Table 7, we found the distribution of LVDD based on the E/A ratio, 12 patients had grade I diastolic dysfunction, and 24 patients had grade II diastolic dysfunction out of 50 patients (Figure 3). A statistically significant association existed between the E/A ratio and diastolic dysfunction with P=0.0118 by the Fisher exact test similar to Dadhicha et al, 18 study, 28 patients had LVDD out of 40 cases of cirrhotic patients studied, another study by Sidmal,15 showed that LVDD was diagnosed in 91.6% of cirrhotic patients,19 patients had mild LVDD. In contrast, 36 patients had moderate to severe LVDD.…”

Section: Discussionsupporting

confidence: 67%

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QTc prolongation and diastolic dysfunction in cirrhosis patients with higher Child-Pugh score

Chandrakant Salve,

Jaiprakash Kuldeep,

Dinesh Singh Mahor

2023

Asian J Med Sci

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Background: Cirrhosis is associated with numerous cardiac abnormalities, which include increased cardiac output, left ventricular diastolic dysfunction, increased wall thickness of cardiac chambers, and pulmonary arterial hypertension. Without further identified cardiac disorders, cirrhotic cardiomyopathy (CCM) is a chronic cardiac dysfunction with an impaired contractile reaction to stress stimuli, impeded diastolic relaxation, and electrophysiological anomalies with a prolonged QT interval. In chronic hepatic disease, echocardiography is a non-invasive method for detecting CCM. Aims and Objectives: The focus was to examine the link between cardiac dysfunction and conduction disturbances in cirrhosis individuals and the extent of the disorder. Materials and Methods: A case–control investigation was conducted at a Medical College. The research involved a cohort of 50 patients and an equal number of 50 healthy controls. The Child-Pugh (CP) Score was utilized to evaluate the degree of liver cirrhosis severity. Bazett’s formula was utilized to compute the QTc interval. The 2D echocardiography revealed the presence of diastolic dysfunction, as evidenced by the E/A ratio. Results: Of 50 patients, 37 (74%) were male, 13 (26%) were female, and the mean age of the patients was 51.76±9.89 years. The E/A ratio in the control group had a mean value of 1.10±0.19, whereas in the cases, it had a mean value of 0.94±0.20. A statistically significant relationship was observed between the control and cases, with a P-value of less than 0.0001. QTc interval between control with a mean value of 382.9±47.34 ms and cases with a mean value of 431.6±62.84 ms was found statistically significant with P<0.0001. Conclusion: QTc prolongation and transmitral flow abnormality are markers of severe cardiac abnormality in patients with higher CP score in cirrhosis. Hence, recognition of such abnormalities in cirrhotic patients may prevent arrhythmogenic cardiovascular deaths in such patients.

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Section: Discussionsupporting

confidence: 67%

“…In the Study by Sidmal et al, 15 the mean age of patients was 53±12 years, including 42 male and 18 female patients.…”

Section: Discussionmentioning

confidence: 97%

QTc prolongation and diastolic dysfunction in cirrhosis patients with higher Child-Pugh score

Chandrakant Salve,

Jaiprakash Kuldeep,

Dinesh Singh Mahor

2023

Asian J Med Sci

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“…By increasing severity of cirrhosis from Child A to Child C, diastolic dysfunction was seemed to worsen. 15…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular dysfunction in patients of cirrhosis of liver

et al. 2019

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Background: Cirrhosis of liver refers to a progressive condition that disrupts the normal architecture of the liver. It is increasingly recognized that cirrhosis per se can cause cardiac dysfunction. The aim was to assess cardiovascular dysfunction electrocardiographically and echocardiographically in patients with cirrhosis of liver and to find the correlation between cardiovascular dysfunction and severity of liver cirrhosis as per child-PUGH score.Methods: Total 90 patients of cirrhosis of liver of both sexes were included in this cross-sectional study conducted from January 2018 to August 2019 in SGRDIMSR, Sri Amritsar. The severity of liver cirrhosis was assessed as per Child Pugh Score. QTc interval was calculated by Bazett’s formula. Systolic and Diastolic dysfunction was seen on 2D-echocardiography.Results: QTc interval increased linearly with the severity of liver cirrhosis. Mean values of QTc in Child Pugh Class A=425.00(±20.97), Class B=437.35(±42.60), Class C=479.71(±29.48) with p value of 0.04 which is significant. Diastolic dysfunction was also related with the severity of liver cirrhosis. In Child Pugh Class A= 2(33%) patients had grade 1 diastolic dysfunction, Class B=23(59%) patients had grade 1 diastolic dysfunction while in Child Pugh Class C=3(7%) had grade 1 diastolic dysfunction, 33(73%) patients had grade 2 diastolic dysfunction and 1(2%) patients had grade 3 diastolic dysfunction with p value of 0.04 which is significant. Systolic function was found normal in all the patients.Conclusions: Diastolic dysfunction and QTc interval prolongation are both related with the severity of liver cirrhosis and are major criteria of cirrhotic cardiomyopathy.

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Diastolic versus systolic dysfunction in patients with chronic liver disease – A single center study in South-South, Nigeria

Njideofor

Okonkwo

Ansa

et al. 2021

CJHS

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Objectives: The term cirrhotic cardiomyopathy (CCM) has been used to describe the constellation of cardiovascular abnormalities including diastolic and systolic dysfunctions in patients with chronic liver disease (CLD). CCM contributes to morbidity and mortality associated with CLD. The aim of the study was to evaluate the left atrial and ventricular geometry, systolic and diastolic functions in patients with CLD. Material and Methods: This was a cross-sectional analytical study that involved 80 patients with CLD seen at University of Calabar Teaching Hospital, Calabar, Nigeria, and 80 apparently healthy controls matched for age/ gender. The participants were interviewed, examined and had resting transthoracic echocardiography. The data were analyzed using IBM SPSS version 20.0. Results: A total of 160 subjects were recruited into the study with a male to female ratio of 2.8:1. There was no difference in the mean age of cases and controls (P = 0.115). Systolic function of the left ventricle was similar in the two arms. However, left ventricular diastolic dysfunction, left atrial enlargement, and increased left ventricular mass index (LVMI) were more prevalent among the patients with CLD compared to controls (P < 0.05). Conclusion: The study demonstrated increased left atrial diameter, increased LVMI associated with diastolic dysfunction, and preserved systolic function at rest among CLD patients.

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Pattern of diastolic dysfunction in alcoholic and non-alcoholic cirrhotic portal hypertensive patients with or without ascites in rural population in South India

Cited by 3 publications

References 28 publications

QTc prolongation and diastolic dysfunction in cirrhosis patients with higher Child-Pugh score

QTc prolongation and diastolic dysfunction in cirrhosis patients with higher Child-Pugh score

Cardiovascular dysfunction in patients of cirrhosis of liver

Diastolic versus systolic dysfunction in patients with chronic liver disease – A single center study in South-South, Nigeria

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