Cardiovascular dysfunction in patients of cirrhosis of liver

Chandey, Manish; Mohan, Gurinder; Kaur, Jaskiran; Vaid, Aarti

doi:10.18203/2349-3933.ijam20195636

Cited by 2 publications

(1 citation statement)

References 5 publications

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“…Class A had no patients; Class B had seven, and Class C had 14 patients, which showed QTC+LVDD. After applying Fisher exact test, P=0.0424 showed a statistically significant correlation similar to Chandey et al, 19 study.…”

Section: Discussionsupporting

confidence: 85%

QTc prolongation and diastolic dysfunction in cirrhosis patients with higher Child-Pugh score

Chandrakant Salve,

Jaiprakash Kuldeep,

Dinesh Singh Mahor

2023

Asian J Med Sci

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Background: Cirrhosis is associated with numerous cardiac abnormalities, which include increased cardiac output, left ventricular diastolic dysfunction, increased wall thickness of cardiac chambers, and pulmonary arterial hypertension. Without further identified cardiac disorders, cirrhotic cardiomyopathy (CCM) is a chronic cardiac dysfunction with an impaired contractile reaction to stress stimuli, impeded diastolic relaxation, and electrophysiological anomalies with a prolonged QT interval. In chronic hepatic disease, echocardiography is a non-invasive method for detecting CCM. Aims and Objectives: The focus was to examine the link between cardiac dysfunction and conduction disturbances in cirrhosis individuals and the extent of the disorder. Materials and Methods: A case–control investigation was conducted at a Medical College. The research involved a cohort of 50 patients and an equal number of 50 healthy controls. The Child-Pugh (CP) Score was utilized to evaluate the degree of liver cirrhosis severity. Bazett’s formula was utilized to compute the QTc interval. The 2D echocardiography revealed the presence of diastolic dysfunction, as evidenced by the E/A ratio. Results: Of 50 patients, 37 (74%) were male, 13 (26%) were female, and the mean age of the patients was 51.76±9.89 years. The E/A ratio in the control group had a mean value of 1.10±0.19, whereas in the cases, it had a mean value of 0.94±0.20. A statistically significant relationship was observed between the control and cases, with a P-value of less than 0.0001. QTc interval between control with a mean value of 382.9±47.34 ms and cases with a mean value of 431.6±62.84 ms was found statistically significant with P<0.0001. Conclusion: QTc prolongation and transmitral flow abnormality are markers of severe cardiac abnormality in patients with higher CP score in cirrhosis. Hence, recognition of such abnormalities in cirrhotic patients may prevent arrhythmogenic cardiovascular deaths in such patients.

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Section: Discussionsupporting

confidence: 85%

QTc prolongation and diastolic dysfunction in cirrhosis patients with higher Child-Pugh score

Chandrakant Salve,

Jaiprakash Kuldeep,

Dinesh Singh Mahor

2023

Asian J Med Sci

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Study of Cardiac Profile in Patients of Liver Cirrhosis

Karwa

Gajbhiye

2022

ijsr

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Background: Liver cirrhosis is the production, in response to chronic liver injury, of degenerative nodules surrounded by brous band. Cirrhotic patients may also have renal, respiratory, hemodynamic and cardiac dysfunction, which increases morbidity and mortality in addition to liver damage. The prevalence of cirrhotic cardiomyopathy is estimated to be between 40 - 50 % in cirrhosis. Present study was aimed to study cardiac prole in patients of liver cirrhosis. Material and Methods: Present study was single-center, observational, cross-sectional study, conducted in patients of age > 18 years, diagnosed case of liver cirrhosis. Child-Pugh-Turcotte Score & MELD Score were calculated. Results: Present study included a total of 103 study participants. The mean age of the study participants was 46.66 ± 9.31 years, majority were males (90.29%) History of alcohol (85.44%) was the most common etiology seen followed by Hepatitis B (9.71%). According to their Child Pugh scores, most (88.35%) of the patients of liver cirrhosis belonged to class C, According to their MELD scores most (88.35%) of the patients of liver cirrhosis belonged to class 3. We found a statistically signicant association between the Child Pugh's class and MELD class (χ2 (1, n=103) =52.956, p = 0.001). The patients of liver cirrhosis who participated in our study are disproportionately distributed in CPclass C and MELD class 3 as compared to the CPclass B and MELD class 2. Conclusion: Diastolic dysfunction is common in patients of liver cirrhosis irrespective of CPand MELD class. Patients of CPclass C and MELD class 3 should be monitored for QTprolongation.

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Cardiovascular dysfunction in patients of cirrhosis of liver

Cited by 2 publications

References 5 publications

QTc prolongation and diastolic dysfunction in cirrhosis patients with higher Child-Pugh score

QTc prolongation and diastolic dysfunction in cirrhosis patients with higher Child-Pugh score

Study of Cardiac Profile in Patients of Liver Cirrhosis

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