Pattern of access determines influence of junk food diet on cue sensitivity and palatability

Kosheleff, Alisa R; Araki, Jingwen; Hsueh, Jennifer; Le, Andrew; Quizon, Kevin; Ostlund, Sean B.; Maidment, Nigel T.; Murphy, Niall P.

doi:10.1016/j.appet.2017.12.009

Cited by 11 publications

(7 citation statements)

References 133 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cue-invigorating food-seeking may be considered adaptive, but the maladaptive eating in the absence of hunger forms the basis for the FA hypothesis. It has been shown that limited or intermittent access to highly palatable foods increase cue-reactivity to these foods, which has implications for the consequences of extreme dieting behavior in humans ( 85 ).…”

Section: Food “Reward” and Accumbens Dopaminementioning

confidence: 99%

Sugar Addiction: From Evolution to Revolution

2018

View full text Add to dashboard Cite

The obesity epidemic has been widely publicized in the media worldwide. Investigators at all levels have been looking for factors that have contributed to the development of this epidemic. Two major theories have been proposed: (1) sedentary lifestyle and (2) variety and ease of inexpensive palatable foods. In the present review, we analyze how nutrients like sugar that are often used to make foods more appealing could also lead to habituation and even in some cases addiction thereby uniquely contributing to the obesity epidemic. We review the evolutionary aspects of feeding and how they have shaped the human brain to function in “survival mode” signaling to “eat as much as you can while you can.” This leads to our present understanding of how the dopaminergic system is involved in reward and its functions in hedonistic rewards, like eating of highly palatable foods, and drug addiction. We also review how other neurotransmitters, like acetylcholine, interact in the satiation processes to counteract the dopamine system. Lastly, we analyze the important question of whether there is sufficient empirical evidence of sugar addiction, discussed within the broader context of food addiction.

show abstract

Section: Food “Reward” and Accumbens Dopaminementioning

confidence: 99%

Sugar Addiction: From Evolution to Revolution

2018

View full text Add to dashboard Cite

show abstract

“…In a related study, we found that rats given intermittent junk-food access were also impaired in a distinct, nonspecific version of the Pavlovian-to-instrumental transfer task ( 8 ). In that study, rats that had been given intermittent access to a junk-food diet showed indiscriminant instrumental food-seeking behavior in response to both food-paired and unpaired cues, unlike chow-fed rats, which showed a selective increase in responding during trials with the food-paired cue.…”

Section: Discussionmentioning

confidence: 93%

“…Overeating and obesity seem to represent a failure of the multifaceted homeostatic processes that regulate energy balance and nutritional diversity ( 4 ), and there is growing evidence that repeated exposure to a junk-food diet can exacerbate the situation by further dysregulating feeding and food seeking. Specifically, animal studies have shown that poor diets (e.g., refined, high-fat, or high-sugar diets) can cause persistent aberrations in behavioral control and cognition, resulting in impulsive decision making ( 5 , 6 ), motivational impairments ( 7 ), and altered food reward liking and craving ( 8 – 13 ).…”

Section: Introductionmentioning

confidence: 99%

Junk Food Exposure Disrupts Selection of Food-Seeking Actions in Rats

et al. 2018

Self Cite

View full text Add to dashboard Cite

There is growing evidence that repeated consumption of highly palatable, nutritionally poor “junk food” diets can produce deficits in cognition and behavioral control. We explored whether long-term junk-food diet exposure disrupts rats' ability to make adaptive choices about which foods to pursue based on (1) expected reward value (outcome devaluation test) and (2) cue-evoked reward expectations (Pavlovian-to-instrumental test). Rats were initially food restricted and trained on two distinct response-outcome contingencies (e.g., left press chocolate pellets, and right press sweetened condensed milk) and stimulus-outcome contingencies (e.g., white noise chocolate pellets, and clicker sweetened condensed milk). They were then given 6 weeks of unrestricted access to regular chow alone (controls) or chow and either 1 or 24 h access to junk food per day. Subsequent tests of decision making revealed that rats in both junk-food diet groups were impaired in selecting actions based on either expected food value or the presence of food-paired cues. These data demonstrate that chronic junk food consumption can disrupt the processes underlying adaptive control over food-seeking behavior. We suggest that the resulting dysregulation of food seeking may contribute to overeating and obesity.

show abstract

“…The number of bursts reflects the incentive motivation triggered by cues because it indicates the activation of responses (Johnson, Sherwood, Smith, Gallagher, & Holland, ; Johnson et al., ; Smith, ). The size of the bursts reflects the hedonic impact of reward (Dwyer, ; Kosheleff et al., ; Mendez, Ostlund, Maidment, & Murphy, ; Ostlund, Kosheleff, Maidment, & Murphy, ), whereas the intraburst lick speed is an indicator of licking‐associated motor control (Gramling & Fowler, ; Gramling, Fowler, & Collins, ).…”

Section: Discussionmentioning

confidence: 99%

Differential effects of dopamine D1‐like and D2‐like receptor agonists on water drinking behaviour under thirsty conditions in mice with reduced dopamine secretion

Kao

Hisatsune

2019

Eur J of Neuroscience

View full text Add to dashboard Cite

The mesolimbic dopamine system is important for reward‐oriented behaviours, such as drinking and eating. However, the precise involvement of dopaminergic neurons and dopamine receptors in water drinking behaviour remains unclear. Here, we generated triple transgenic mice harbouring Slc6a3(DAT)‐icre/ERT2, Camk2a‐loxP‐STOP‐loxP‐tetracycline transactivator and tetO‐tetanus toxin constructs, in which the release of dopamine is blocked by tetanus toxin. These mice, referred to as dopamine secretion interference mice, had reduced dopamine secretion in the striatum (61.4%) and the nucleus accumbens (54.5%). They showed adequate limb strength and food consumption, similarly to control mice, but exhibited motor control impairment in a challenging rotarod test. Dopamine secretion interference mice made fewer licks and had fewer bursts than control mice during a licking test under thirsty conditions. To elucidate the influence of dopamine receptors in the altered drinking behaviour, a dopamine D1 or D2/D3 receptor agonist (A68930 or ropinirole, respectively) was administered prior to the licking microstructure analysis. Treatment with the D1 agonist restored the total number of licks but not the burst number in dopamine secretion interference mice. By contrast, the D2/3 agonist impeded water drinking behaviour in both transgenic and control mice. The present findings indicate that D1 receptor activation partially ameliorates the altered drinking behaviour of the dopamine secretion interference mice and suggest that D1 receptor activity impacts drinking under thirsty conditions.

show abstract

Pattern of access determines influence of junk food diet on cue sensitivity and palatability

Cited by 11 publications

References 133 publications

Sugar Addiction: From Evolution to Revolution

Sugar Addiction: From Evolution to Revolution

Junk Food Exposure Disrupts Selection of Food-Seeking Actions in Rats

Differential effects of dopamine D1‐like and D2‐like receptor agonists on water drinking behaviour under thirsty conditions in mice with reduced dopamine secretion

Contact Info

Product

Resources

About