Pattern electroretinogram in neuromyelitis optica and multiple sclerosis with or without optic neuritis and its correlation with FD-OCT and perimetry

Abstract

Pattern electroretinogram measurements were able to detect RNFL loss in MS + ON and NMO eyes, with a performance comparable to OCT. PERG amplitude measurements were reasonably well correlated with OCT-measured parameters.

Evaluation of retinal nerve fiber layer thickness measured by optical coherence tomography in Moroccan patients with multiple sclerosis

“…Indeed, many studies have reported a reduction in macular volume and macular ganglion cell complex thickness in MS [8,19,20,23]. Similarly, in the present study, GC-IPL and mNFL thicknesses were lower in MS patient's eyes than in HC eyes.…”

“…The association between RNFL thinning and MS is marked by various studies [3][4][5][6][7][8][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]. Likewise, in this study, MS patients' eyes showed statistically significantly lower values of the total RNFL than the HC eyes.…”

“…Since 2006, interest in the study of the RNFL thickness by OCT in MS patients is growing and several publications have emerged [1][2][3][4][5][6][7][8][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25].…”

Optical Coherence Tomography in Multiple Sclerosis

“…48 Visual field sensitivity (as measured by the mean deviation (MD) from age-matched normal values) is reduced in MS patients relative to normal subjects, with the greatest reduction being observed in those eyes with a history of ON. 49,50 Mean deviation is correlated with TD-OCT-derived RNFL thickness in MS eyes with a history of ON, 51,52 although the quantitative relationship with deeper retinal layers remains unstudied. Given that MS patients are prone to fatigue 53 and the adverse effects of fatigue on both visual sensitivity and reliability when performing perimetry, 48 more objective measures of visual function (such as electrophysiology) are likely to be helpful when assessing MS patients.…”

Eletrorretinograma de padrão reverso macular e multifocal e tomografia de coerência óptica em olhos suspeitos de glaucoma e glaucomatosos com perda de hemicampo

“…Nos últimos anos, novos aparelhos de TCO foram introduzidos possibilitando incorporar softwares para este tipo de análise o que melhorou em muito o desempenho dos parâmetros maculares na quantificação da integridade neural da retina em várias afecções da via visual anterior incluindo o glaucoma (74)(75)(76) .…”