Pattern electroretinogram: Effects of miosis, accommodation, and defocus

Leipert, K. P.; Gottlob, Irène

doi:10.1007/bf00143951

Cited by 25 publications

(19 citation statements)

References 18 publications

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“…Nor was it attributable to an error of refraction nor to variations in the level of anaesthesia. Neither defocus nor a reduction in contrast caused a prolongation of the time-to-peak of the PERG, which agrees with the results of Arden et al [3] and Leipert and Gottlob [34], respectively. The inter-leaving of recordings from left and right eyes essentially rule out a time-dependent change in the level of anaesthesia.…”

Section: Discussionsupporting

confidence: 82%

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Abnormality of the pattern electroretinogram and pattern visual evoked cortical response in esotropic cats

1989

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In six 3-week-old kittens, the tendon of the lateral rectus muscle of one eye was sectioned under anaesthesia in order to induce an esotropic (nasally-directed) squint. At maturity, the pattern electroretinogram (PERG) and pattern visual evoked response (PVER) were recorded under anaesthesia to phase-reversal at 1.67 Hz of a 0.5c/deg square wave grating pattern of 75% contrast. Refraction was determined by retinoscopy and confirmed by recording the PERG for different trial lenses. The amplitude and time-to-peak of the PERG and PVER were compared between operated and unoperated eyes, and with the responses of one normal and two sham-operated cats. With stimulation of the operated eye, the amplitude of the PVER was consistently reduced by 50% compared with the non-operated eye, confirming that the cats had become amblyopic as a result of the squint. While the appreciable inter-eye variations in the amplitude of the PERG of the normal and sham-operated cats precluded identification of a change in the esotropic cats, there was a consistent prolongation of the time-to-peak of the PERG by 50% with stimulation of the operated eye. This result is consistent with a retinal component to strabismic amblyopia.

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Section: Discussionsupporting

confidence: 82%

“…Should the effective illumination at the retina be reduced, this would delay the time-to-peak of the PERG [34,49]. However, it is unlikely that the esotropic eye had diminished ocular transmission since the fundus had a normal appearance with reverse ophthalmoscopy.…”

Section: Discussionmentioning

confidence: 99%

Abnormality of the pattern electroretinogram and pattern visual evoked cortical response in esotropic cats

1989

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“…Under experimental conditions latency delays may also be evoked in pattern ERG by stimulus variation, e.g., by an alteration of the mean luminance [18,19] or in cases of maculopathy. However, the absence of latency delays in the pattern ERG of amblyopic children was clearly shown in this study.…”

Section: Discussionmentioning

confidence: 99%

Retinal and retinocortical times to pattern stimulation in amblyopic children

1989

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In order to determine whether in amblyopes retinal conduction delays contribute to the cortical measureable delays in the visual evoked cortical potential (VECP), peak latencies of the pattern electroretinogram (ERG) are measured in amblyopic children. The results are compared with those of the normal fellow eyes and those of a healthy control group. Simultaneously the latencies in the VECP are recorded and the determination of the retinocortical times is performed. Statistically retinal b-wave (Q) and a-wave (P) of the pattern ERG of amblyopic eyes do not show significant delays of peak latency. In retincortical times, however, there are significant prolongations. During occlusion therapy retinocortical values of normal fellow eyes are also delayed in comparison with the control group. A pathological conduction delay of visual information on the retinal level up to the generators of the pattern ERG can thus be excluded in amblyopia. The total latency delay in the VECP of amblyopes consists solely in a prolongation of retinocortical times.

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“…Jede qualitative Minderung des durch das Reizmuster entstehenden optischen Netzhautbildes reduziert das PERG-Signal [34,35,36]. Dies liegt an der dabei auftretenden Kontrastminderung, die das PERG stark beeinflusst [20,21,22].…”

Section: Notwendigkeit Einer Guten Optischen Abbildung Beim Pergunclassified

Elektrophysiologische Untersuchungsmethoden in der Glaukomdiagnostik

Poloschek¹,

Bach²

2012

Ophthalmologe

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The two currently used most successful techniques for early detection of glaucoma are described. (1) The pattern electroretinogram (PERG) allows detection of incipient glaucomatous damage in eyes with ocular hypertension up to 4 years ahead of manifest glaucoma with a sensitivity and specificity of approximately 75%. This is achieved by selecting optimized stimulation (check size and stimulation frequency) and analysis protocols (amplitude ratio to different check sizes). The major disadvantage is the requirement for best corrected visual acuity to be at least 0.8(decimal) to avoid false positive results. (2) The photopic negative response (PhNR), a component of the Ganzfeld ERG, does not suffer from optical factors reducing visual acuity. It is also affected in early glaucoma but so far has not achieved the same sensitivity and specificity as the PERG.

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Pattern electroretinogram: Effects of miosis, accommodation, and defocus

Cited by 25 publications

References 18 publications

Abnormality of the pattern electroretinogram and pattern visual evoked cortical response in esotropic cats

Abnormality of the pattern electroretinogram and pattern visual evoked cortical response in esotropic cats

Retinal and retinocortical times to pattern stimulation in amblyopic children

Elektrophysiologische Untersuchungsmethoden in der Glaukomdiagnostik

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