Pattern-coated titanium bone fixation plate for dual delivery of vancomycin and alendronate

Park, Chun Gwon; Park, Min; Kim, Byung Hwi; Lee, Seung Ho; Park, Joong Yull; Park, Ho Hyun; Lee, Kangwon; Seok, Hyun‐Kwang; Choy, Young Bin

doi:10.1007/s13233-017-5073-1

Cited by 8 publications

(5 citation statements)

References 35 publications

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“…In this strategy, the CS-SH solution contained the drug of interest (risedronate) before mixing with the counterpart solution. The cationic amine groups of CS would form an ionic complex with the negatively charged risedronate, thereby sustaining drug release. At the same time, the gelled hydrogel resides in the bone defect according to the degradation profile of the hydrogel (Figure ).…”

Section: Discussionmentioning

confidence: 99%

“…MG-63 cells were seeded in the lower chamber of a transwell plate at a density of 2 × 10 4 cells/well and incubated for 24 h to evaluate the osteogenic differentiation of preosteoblasts. After that, the culture medium was replaced with an osteogenic differentiation medium of DMEM supplemented with 10% FBS, 100 units/ml penicillin, and 100 μg/mL of streptomycin, containing 10 mM β-glycerophosphate, 2 mM l -glutamine, 10 nM dexamethasone and 50 μg/mL l -ascorbic acid . The 20 μL of sterilized hydrogel, containing 26.6 μg risedronate for the M0/R and M75/R, was placed in the upper chamber and incubated in an osteogenic medium containing 0.3 mM H 2 O 2 .…”

Section: Methodsmentioning

confidence: 99%

“…The 20 μL of sterilized hydrogel, containing 26.6 μg risedronate for the M0/R and M75/R, was placed in the upper chamber and incubated in an osteogenic medium containing 0.3 mM H 2 O 2 . After incubation for 7 days, alkaline phosphatase (ALP) activity was analyzed using a p-nitrophenyl phosphate (pNPP) alkaline phosphatase assay kit (AnaSpec, CA, USA) . The absorbance at 405 nm was measured using a microplate reader to quantify the osteogenic activity.…”

Section: Methodsmentioning

confidence: 99%

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In Situ Hydrogel with Immobilized Mn-Porphyrin for Reactive Oxygen Species Scavenging, Oxygen Generation, and Risedronate Delivery in Bone Defect Treatment

Kim,

Yoon,

et al. 2024

ACS Appl. Mater. Interfaces

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We propose a hydrogel immobilized with manganese porphyrin (MnP), a biomimetic superoxide dismutase (SOD), and catalase (CAT) to modulate reactive oxygen species (ROS) and hypoxia that impede the repair of large bone defects. Our hydrogel synthesis involved thiolated chitosan and polyethylene glycolmaleimide conjugated with MnPs (MnP-PEG-MAL), which enabled in situ gelation via a click reaction. Through optimization, a hydrogel with mechanical properties and catalytic effects favorable for bone repair was selected. Additionally, the hydrogel was incorporated with risedronate to induce synergistic effects of ROS scavenging, O 2 generation, and sustained drug release. In vitro studies demonstrated enhanced proliferation and differentiation of MG-63 cells and suppressed proliferation and differentiation of RAW 264.7 cells in ROS-rich environments. In vivo evaluation of a calvarial bone defect model revealed that this multifunctional hydrogel facilitated significant bone regeneration. Therefore, the hydrogel proposed in this study is a promising strategy for addressing complex wound environments and promoting effective bone healing.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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In Situ Hydrogel with Immobilized Mn-Porphyrin for Reactive Oxygen Species Scavenging, Oxygen Generation, and Risedronate Delivery in Bone Defect Treatment

Kim,

Yoon,

et al. 2024

ACS Appl. Mater. Interfaces

Self Cite

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“…The technique of biopanning by phage is an effective method to find tissue-specific peptides, so it will be of great clinical significance to screen peptides with stronger stability and bone inducing effect via this method [ 193 ]. Furthermore, the use of alendronate, simvastatin, icariin, and other osteogenic inducers with better biological stability than growth factors combined with antimicrobial agents is likewise an option [ [194] , [195] , [196] , [197] ]. However, the osteogenic induction effect of these drugs is not as strong as that of the growth factors, and high concentrations of these drugs inhibits osteogenesis.…”

Section: Dual-functional Drug Delivery Systemmentioning

confidence: 99%

Dual-functional composite scaffolds for inhibiting infection and promoting bone regeneration

Cui

Tian

et al. 2022

Materials Today Bio

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“…In addition to HA, the organic materials loaded with BPs are coated on the surface of Ti scaffolds. Park et al prepared a pattern‐coating with a mixture of PLGA and vancomycin or ALN on the flat surface of the Ti‐containing scaffold. This composite Ti graft showed good stability and sustained drug release for up to 28 days, as well as excellent osteogenic and antibacterial effects.…”

Section: Bp‐incorporated Composite Scaffolds For Enhanced Bone Defectmentioning

confidence: 99%

Bisphosphonate‐Functionalized Scaffolds for Enhanced Bone Regeneration

Cui

Zhu

et al. 2019

Adv Healthcare Materials

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Bone defect healing is an intricate but methodical process that restores bone integrity and represents an intrinsic capacity of The local sustained release of bioactive substances are attracting increasing attention in bone tissue engineering, which is beneficial to bone tissue formation and helps to improve the bone ingrowth ability of a scaffold. Bisphosphonates (BPs), as a representative kind of osteoclast inhibitors, are proven to possess excellent osteogenic induction capability. Accordingly, various physical and chemical strategies are developed to functionalize bone tissue scaffolds with BPs to achieve controlled release profiles. Compared with traditional treatment modalities, local release of BPs from these composite scaffolds will contribute to continuous bone integration without the risk of many complications. This review explores the molecular mechanisms of BPs on bone metabolism and analyzes the appropriate concentrations of BPs that promote bone regeneration. The advanced BP loading strategies, implant modification technologies, and BP-loaded composite scaffolds based on different matrices are summarized. Finally, the latest advances and the future development of BP-modified scaffolds for enhanced bone regeneration are discussed. This article provides leading-edge design strategies of the BP-functionalized bone engineering scaffolds for improved bone repairability.

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Pattern-coated titanium bone fixation plate for dual delivery of vancomycin and alendronate

Cited by 8 publications

References 35 publications

In Situ Hydrogel with Immobilized Mn-Porphyrin for Reactive Oxygen Species Scavenging, Oxygen Generation, and Risedronate Delivery in Bone Defect Treatment

In Situ Hydrogel with Immobilized Mn-Porphyrin for Reactive Oxygen Species Scavenging, Oxygen Generation, and Risedronate Delivery in Bone Defect Treatment

Dual-functional composite scaffolds for inhibiting infection and promoting bone regeneration

Bisphosphonate‐Functionalized Scaffolds for Enhanced Bone Regeneration

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