Pattern and prevalence of physiological cutaneous changes in pregnancy: A study of 2000 antenatal women

Rathore, Shagufta P; Gupta, Sandeep; Gupta, Vipin

doi:10.4103/0378-6323.79741

Cited by 47 publications

(62 citation statements)

References 5 publications

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“…4 The mean age in this study 27.3 years which is higher compared to other studies by Kumari et al and Muzzafir et al 5,6 This could be due to relatively earlier age at marriage in other states compared to our state.…”

Section: Parity and Agecontrasting

confidence: 54%

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A study of pregnancy specific dermatoses and their effect on the outcome of pregnancy

2017

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Background: Pregnancy being a complex state, the interactions of multiple factors result in a number of cutaneous findings that can be separated into physiologic changes, pre-existing dermatoses that can be aggravated or improved during pregnancy and dermatoses that are specific to pregnancy. Dermatoses specific to pregnancy are important to recognise because they may be pruritic or painful to the mother and may pose significant risk to mother, her fetus or both. Early identification of the condition may go a long way in preventing morbidity and mortality.Methods: Antenatal women attending dermatology outpatient for dermatologic problems or referred from Obstetrics and Gynaecology, department for skin conditions in a tertiary care hospital in Kottayam, Kerala state were taken up for the study. Pregnancy related dermatoses or physiologic changes due to pregnancy if present were noted. The patients were followed up till delivery and the pregnancy outcome recorded. The results were analyzed using SPSS.Results: 94.3% of the patients had physiological changes, hyperpigmentation being the commonest. Specific pregnancy dermatoses were present in 38.3%. 94% of pregnancy dermatoses occurred during third trimester. The most common specific dermatoses observed was pruritic urticarial papules and plaques of pregnancy (PUPPP)-63.6%. It is more common in primi gravida (30/42), in twin pregnancies, in mothers of babies with more birth weight, male babies and those with gestational diabetes mellitus. None of the specific dermatoses produced adverse fetal outcome. Conclusions: Pregnancy dermatoses usually manifest in the third trimester. PUPPP is the commonest pregnancy dermatosis. PUPPP is more common among mothers with increased body weight, gestational diabetes, in twin pregnancy and in mothers with male babies. Most of the common pregnancy dermatoses have no adverse effect on the fetus.

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Section: Parity and Agecontrasting

confidence: 54%

“…Hyperpigmentation was the commonest physiological change (90.3%) as in other studies by Rathore et al, Kumari et al and Muzzafir et al [4][5][6] …”

Section: Physiological Changesmentioning

confidence: 59%

A study of pregnancy specific dermatoses and their effect on the outcome of pregnancy

2017

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“…[4] The exact cause of melasma is unknown. However, multiple factors are implicated in its etiopathogenesis, mainly sunlight, genetic predisposition, pregnancy, thyroid disorders, certain drugs and female hormonal activity [5,6,7]. Dermatopathic anemia has attracted the attention of clinicians because iron deficiency was On clinical examination patients were classified into three types: centrofacial, malar and mandibular type.…”

Section: *Correspondencementioning

confidence: 99%

Serum Iron profile in Female patients of Melasma-A case control study

Qazi¹,

Dogra²,

Dogra³

2017

APJHS

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Background: Melasma is a common acquired pigmentary dermatosis characterized by presence of symmetric, hyperpigmented patches, most commonly seen on the face. It is most commonly seen in young to middle aged females. The exact cause of melasma is not known, however a number of factors have been implicated in its etiopathogenesis. The effect of body iron stores on melasma is not exactly known. Although iron overload has been seen to affect skin pigmentation, effect of low body iron stores on skin pigmentation is unknown. In this study, we evaluated total body iron stores by assessing serum iron , ferritin and total iron binding capacity (TIBC) level among nonpregnant females with and without melasma. Materials and Methods: A cross-sectional case control study was conducted in 2016 at Department of Dermatology, Government Medical College, Jammu for a period of one year. The study comprised of 70 non pregnant females with and without melasma . Serum iron level, TIBC and ferritin in the two groups were measured and compared. The severity of melasma was assessed on the basis of MASI score. The correlation between severity of melasma and derangements in iron profile were also assessed in the study. Results: Comparison of serum Iron levels in cases and controls showed lower levels in patients of melasma(58.84± 29.17) as compared to control population (82.26± 45.83) ;p<0.001. Serum ferritin levels were found to be lower in patients of melasma (20.06±18.64) as compared tp control population(42.29±30.08);p<0.001.Comparison of serum TIBC between cases and controls showed higher values in cases(424±58 98.33) compared to control population (384.45± 74.55) p<0.007.Also a positive correlation was found between severity of melasma as per MASI score and derangement in Iron profile. Conclusion: Serum Iron, ferritin levels were found to be significantly lower in patients of melasma compared to the control population whereas Total iron binding capacity(TIBC) was found to be higher in patients of melasma compared to the control population indicating low body iron storesin patients of melasma. The severity of maelasma as per MASI score correlated well with the derangements in iron profile. Hence patients with melasma had low body Iron stores compared to control population indicating a possible role of iron deficiency in the etiopathogenesis of melasma.

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“…A bit higher percentage has been reported by other authors. [8,13] PUPPP (also known as polymorphic eruption of pregnancy) was the commonest specific disorder of pregnancy accounting for 5.57% followed by prurigo of pregnancy with 12 (3.52%) cases and pruritus gravidarum (also known as intrahepaticcholestasis of pregnancy) with 4 (1.17%) cases. Similar to our study, PUPPP was reported as commonest specific dermatoses of pregnancy in study by Kumari R [9] accounting for 63.6% cases followed by pruritus gravidarum while Shivakumar and Madhavamurthy [11] reported prurigo of pregnancy as the commonest specific dermatoses of pregnancy with incidence of 9.41% followed by pruritus gravidarum.…”

Section: Discussionmentioning

confidence: 99%

“…This was found to be consistent with other studies. [13] Vascular changes result from distension, instability and proliferation of vessels [4] and were seen in 45.16 % of cases. Non pitting edema over the hands, feet and face was observed in 35.78% cases.…”

Section: Discussionmentioning

confidence: 99%