Pattern and clinical management of penile cancer in Rwanda

Ngendahayo, E.; Nzayirambaho, Manassé; Bonane, Alex; Gasana, George; Ssebuufu, Robinson; Umurangwa, F.; Muhawenimana, Emmanuel; Nyirimodoka, Alexandre; Nzeyimana, Innocent; Rugwizangoga, Belson; Muvunyi, Thierry Zawadi; Musoni, Emile; Bwogi, S.; Hategekimana, Théobald; Kalengayi, R.; Rwamasirabo, Emile

doi:10.1016/j.afju.2018.07.001

Cited by 4 publications

(2 citation statements)

References 21 publications

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“…22 Conversely, another study found no effect of HIV status (in patients undergoing ART for more than 2 years) on disease characteristics or progression. 29 These findings highlight the varying phenotypic spectrum of HIV disease, from undetectable viral load to AIDS, variability that has not been controlled for in this review. Indeed, the question of whether effective ART negates the effect of HIV on PeSCC is an intriguing area for further research.…”

Section: Discussionmentioning

confidence: 88%

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The association between penile cancer and HIV infection: A literature review

et al. 2023

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Penile cancer is a rare malignancy which HIV infection appears to increase the risk of. The magnitude of this risk and the pathogenesis remain unclear. A comprehensive review of the literature was undertaken using conventional search strategies. Twenty-four publications were identified by this methodology, of which nine were case reports and 15 were observational studies. These studies were highly heterogeneous, with varying study designs, populations, and objectives. The risk of penile cancer within HIV-positive individuals is significantly greater than in those without HIV (RR = 3 .7 to 5.8, 3 studies; SIR = 3.8 to 11.1, 4 studies). HIV is also shown to influence disease characteristics, with a four-fold increased risk of death from penile cancer. Moreover, progression from intraepithelial neoplasia occurs earlier in HIV, six years sooner than in HIV-negative men. HIV-positive men have a higher prevalence of HPV infection. Ethnicity is also shown to modulate the relationship between HIV and penile carcinoma, with a higher risk of cancer in Hispanic, compared with Caucasian, HIV-positive men. This review has collated data from diverse sources to improve understanding of the relationship between HIV and penile cancer. This relationship has been quantitatively and qualitatively characterised and highlights areas deserving further enquiry.

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Section: Discussionmentioning

confidence: 88%

“…In the study by Ngendahayo and colleagues, out of 30 Rwandan men with PeSCC, six were HIV positive and undergoing antiretroviral therapy (ART) for at least two years. 29 In them, HIV infection showed no relationship to disease presentation or progression.…”

Section: Resultsmentioning

confidence: 99%

The association between penile cancer and HIV infection: A literature review

et al. 2023

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Assessment of the impacts of selected physicochemical and bacteriological parameters of wastewater (hospital effluents) from the University teaching hospital of Butare on the surrounding environment

Baranyika

Katabarwa²,

Nyirimbibi

et al. 2023

Journal of Cleaner Production

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Management guidelines of penile cancer- a contemporary review of sub-Saharan Africa

Cassell

Yunusa

Manobah

et al. 2020

Infect Agents Cancer

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Background Penile cancer is a rare malignancy with prevalence higher in areas of high Human Papilloma Virus (HPV) such as Africa, Asia and South America. In middle- and low-income countries where circumcision is not routinely practiced, the rate of penile cancer could be ten times higher. Main body of the abstract A literature review was conducted from 1992 to 2019 using PubMed, Google Scholar, African Journal Online and Google with inclusion of 27 publications with emphasis on the Sub-Saharan literature. Findings revealed that most men with penile cancer in Sub-Saharan Africa (SSA) present with locally advanced to advanced disease with devastating consequences. The option of penile sparing procedure is reduced with most treatment option directed to mutilating surgeries. The lack of appropriate chemotherapy and radiotherapy worsens the prognosis in the region. Short conclusion Human Papilloma Virus (HPV) vaccination may not be cost-effective for most regions in SSA. Therefore, early childhood circumcision might be the best advocated alternative for prevention.

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Pattern and clinical management of penile cancer in Rwanda

Cited by 4 publications

References 21 publications

The association between penile cancer and HIV infection: A literature review

The association between penile cancer and HIV infection: A literature review

Assessment of the impacts of selected physicochemical and bacteriological parameters of wastewater (hospital effluents) from the University teaching hospital of Butare on the surrounding environment

Management guidelines of penile cancer- a contemporary review of sub-Saharan Africa

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