Patients with vitiligo present fewer cardiovascular risk factors: results from a case–control study

Rodríguez-Martín, Marisa; Paz, Nayra Merino de; Mehtani, P.; Ferrer, Patricia Contreras; Eliche, Mar Pestana; Martin, Billie-Jean; Sáez, María Eugenia; García, Miquel Barceló; Noda, Aiji

doi:10.1111/j.1468-3083.2011.04392.x

Cited by 19 publications

(26 citation statements)

References 12 publications

(17 reference statements)

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“…All our findings provide evidence that lipid disturbances may develop even in young vitiligo patients, which would stand in contradiction to the view of Rodríguez‐Martín et al. who claimed otherwise. In their recent study, comprising 105 active nonsegmental vitiligo patients aged 14–85 years, Rodríguez‐Martín et al.…”

Section: Introductioncontrasting

confidence: 99%

“…All our findings provide evidence that lipid disturbances may develop even in young vitiligo patients, which would stand in contradiction to the view of Rodríguez-Martín et al (7) who claimed otherwise. In their recent study, comprising 105 active nonsegmental vitiligo patients aged 14-85 years, Rodríguez-Martín et al (7) found out that the studied patients presented a better lipid profile, with higher levels of HDL and lower triglyceride, in comparison with the control group. Even though in their opinion vitiligo patients might be at a lower cardiovascular risk because of the controversial choice of the studied subjects (i.e., their age, sex), the results of Rodríguez-Martín et al are debatable.…”

Section: Introductioncontrasting

confidence: 99%

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Metabolic syndrome in vitiligo

et al. 2012

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Vitiligo is an acquired, depigmenting skin disease with still unclear, multifactorial etiopathogenesis. However, there is growing evidence that vitiligo affects not only the skin but it may also be connected with metabolic abnormalities, including glucose intolerance and lipid abnormalities, all of which confirms the systemic nature of the disease. Recently, it has been shown that melanocytes, especially those found in the adipose tissue, due to their ability to decrease inflammation and oxidative damage, are capable of preventing the metabolic syndrome. The article presents updated knowledge on potential metabolic disturbances in vitiligo.

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Section: Introductioncontrasting

confidence: 99%

Section: Introductioncontrasting

confidence: 99%

Metabolic syndrome in vitiligo

et al. 2012

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“…Therefore, the authors suggested that vitiligo patients might have a lower cardiovascular risk. But they did not mention about the severity or type of vitiligo, be it focal or generalized, in their study cohort [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Neutrophil to lymphocyte ratio in patients with vitiligo

Solak¹,

Dikicier²,

Coşansu³

et al. 2017

pdia

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IntroductionThere are a few studies showing an increased risk of insulin resistance, metabolic syndrome, and oxidative stress in patients with vitiligo.AimTo investigate whether systemic inflammation is increased in vitiligo patients in a case-control study design.Material and methodsNonsegmental vitiligo patients who had been followed at the outpatient dermatology clinic of a university-affiliated teaching hospital, and healthy controls were enrolled in the study. Patients who were receiving systemic treatments and having a systemic disease such as diabetes mellitus and thyroiditis were excluded. Demographic features were recorded and peripheral blood samples were taken from all participants to study serum whole blood count, creatinine, and C-reactive protein (CRP).ResultsFifty patients with localized vitiligo, 43 patients with generalized vitiligo, and 50 healthy volunteers were enrolled in the study. Neutrophil to lymphocyte ratio and serum CRP levels were significantly higher in patients who have generalized vitiligo than those with localized vitiligo and healthy controls. However, there was no significant difference regarding neutrophil to lymphocyte ratio (NLR) and CRP between localized vitiligo and control groups.ConclusionsPatients with generalized vitiligo seem to have increased systemic inflammation compared with localized vitiligo and control subjects in our cohort. To the best of our knowledge, this is the first study in the literature showing increased NLR values in generalized vitiligo patients. Further studies with cardiovascular disease markers are required to elicit this association better.

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“…A recent report provided information on the reduction of some cardiovascular risk factors in patients with vitiligo. However, the relationship between vitiligo and cardiovascular disease is not yet clear and no association between vitiligo and obesity has ever been documented in a case-control study [20] .…”

Section: Introductionmentioning

confidence: 99%

No Association between Vitiligo and Obesity: A Case-Control Study

Dragoni¹,

Conti²,

Cazzaniga³

et al. 2017

Med Princ Pract

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Objective: The purpose of this study was to investigate the relationship between vitiligo and body mass index (BMI) to assess the possible association between vitiligo and obesity. Subjects and Methods: This was a case-control study on a total of 400 participants, i.e., 200 patients with vitiligo and 200 healthy volunteers. Medical assessments were performed by dermatologists using the modified Vitiligo European Task Force form. The height and weight of all of the participants were measured and used to calculate the BMI. Data were analyzed using multivariate logistic regression models. Adjustment for age and gender was carried out preliminarily in the case-control analysis, whereas a forward stepwise selection algorithm was used to assess which independent factors were associated with a BMI ≥30 or a BMI ≤18.5. Results: Comparison of the vitiligo and control groups revealed the absence of a significant association. The multivariate analysis of factors associated with a high BMI (≥30) in vitiligo patients showed a significant association between a high BMI and a sudden onset of vitiligo (p = 0.021; OR = 3.83; 95% CI 1.22-11.99) and the presence of inflammation and pruritus (p = 0.031; OR = 3.26; 95% CI 1.11-9.57). No significant association was observed in the analysis of factors associated with a low BMI (≤18.5) in vitiligo patients. Conclusion: In this study, vitiligo did not appear to be associated with a high BMI; obesity might not be a risk factor for vitiligo, in contrast to most autoimmune diseases which are significantly associated with obesity.

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Patients with vitiligo present fewer cardiovascular risk factors: results from a case–control study

Cited by 19 publications

References 12 publications

Metabolic syndrome in vitiligo

Metabolic syndrome in vitiligo

Neutrophil to lymphocyte ratio in patients with vitiligo

No Association between Vitiligo and Obesity: A Case-Control Study

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