No Association between Vitiligo and Obesity: A Case-Control Study

Abstract

Objective: The purpose of this study was to investigate the relationship between vitiligo and body mass index (BMI) to assess the possible association between vitiligo and obesity. Subjects and Methods: This was a case-control study on a total of 400 participants, i.e., 200 patients with vitiligo and 200 healthy volunteers. Medical assessments were performed by dermatologists using the modified Vitiligo European Task Force form. The height and weight of all of the participants were measured and used to calculate the BMI. Data were analyzed using multivariate logistic regression models. Adjustment for age and gender was carried out preliminarily in the case-control analysis, whereas a forward stepwise selection algorithm was used to assess which independent factors were associated with a BMI ≥30 or a BMI ≤18.5. Results: Comparison of the vitiligo and control groups revealed the absence of a significant association. The multivariate analysis of factors associated with a high BMI (≥30) in vitiligo patients showed a significant association between a high BMI and a sudden onset of vitiligo (p = 0.021; OR = 3.83; 95% CI 1.22-11.99) and the presence of inflammation and pruritus (p = 0.031; OR = 3.26; 95% CI 1.11-9.57). No significant association was observed in the analysis of factors associated with a low BMI (≤18.5) in vitiligo patients. Conclusion: In this study, vitiligo did not appear to be associated with a high BMI; obesity might not be a risk factor for vitiligo, in contrast to most autoimmune diseases which are significantly associated with obesity.

Metabolic Derangement in Patients with Vitiligo: A Cross-Sectional Study

“…In a study by Dragoni et al , same to ours, vitiligo was revealed not to have any relationship with BMI 18. In contrast, Singh et al reported higher BMI in patients with vitiligo, compared with controls 17.…”

“…3-6 16 17 In a study by Dragoni et al, same to ours, vitiligo was revealed not to have any relationship with BMI. 18 In contrast, Singh et al reported higher BMI in patients with vitiligo, compared with controls. 17 This discrepancy between results might be explained by different mean values of BMI in these studies.…”

Measurement of Serum Prolactin Level in Vitiligo Patients and its Correlation with Prolactin Gene Polymorphism

“…The creators proposed that in spite of the fact that insulin opposition is expanded in patients with vitiligo, various instruments other than stoutness might be answerable for insulin obstruction in such patients. Besides, Dragoni et al [8] indicated that vitiligo didn't seem, by all accounts, to be related with a high BMI. This absence of an affiliation could be because of a high articulation of p53 and a high centralization of Despite the fact that, stoutness is a proinflammatory condition wherein hypertrophic adipocytes and fat tissueinhabitant cells add to increment circling levels of proinflammatory cytokines [9].…”

Does weight loss lead to improvement of dermatological conditions: what is the evidence?

“…53 A previous study concluded that vitiligo did not have any significant association with higher BMI, although they found a significant association between sudden onset of vitiligo and high BMI. 54 The authors postulated that these results could be explained by the higher expression of p53 (which has a suppressive effect on white adipocyte differentiation, and is thus protective against diet-induced obesity) and the high concentration of transforming growth factor-b (a potent inhibitor of white adipose tissue differentiation). [55][56][57]…”