Patients with Schizophrenia Remember that an Event has Occurred, but not When

Rizzo, Lydia; Danion, Jean-Marie; Linden, Martial Van der; Grangé, Danielle

doi:10.1192/bjp.168.4.427

Cited by 97 publications

(51 citation statements)

References 10 publications

(4 reference statements)

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“…There is a considerable amount of literature on memory and possible biases of retrospective assessment (Friedman, 1993). The fact that a certain event has occurred is more accurately recalled than the time when it occurred (Rizzo et al, 1996). Fendrich et al (1990) found that the stability of recall for anxiety disorders was poorer than for other DSM-III mental disorders.…”

Section: Comorbid Psychiatric Conditionsmentioning

confidence: 98%

Six-year course of bulimia nervosa

Fichter

Quadflieg

1997

Int. J. Eat. Disord.

131

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Section: Comorbid Psychiatric Conditionsmentioning

confidence: 98%

Six-year course of bulimia nervosa

Fichter

Quadflieg

1997

Int. J. Eat. Disord.

131

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“…31,63,64 This interpretation is corroborated by a previous study from MacDonald et al 31 that demonstrates that, instead of using context processing, schizophrenic patients may use an inefficient encoding and retrieval episodic strategy-related to enhanced activation in rostral LPFC. In this line of arguments, the disruption of episodic control observed in schizophrenic patients could be the result of an inappropriate binding process between temporal and more immediate aspects of information 65,66 that may be due to a primary inefficient encoding strategy of contextual cues. …”

Section: Commentmentioning

confidence: 99%

Organization of Cognitive Control Within the Lateral Prefrontal Cortex in Schizophrenia

Barbalat¹,

Chambon²,

Franck³

et al. 2009

Arch Gen Psychiatry

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In schizophrenic patients, the architecture of cognitive control follows the cascading organization from rostral LPFC regions to caudal LPFC and premotor regions depending on the temporal framing of action and events. We found, however, that immediate contextual signals insufficiently bias the caudal LPFC activity required to select the appropriate behavioral representation. This specific deficit could thus alter the internal consistency of schizophrenic patients' behavior. To compensate for this weakening of contextual influence, schizophrenic patients may inefficiently use temporal episodic information through higher activation in rostral LPFC regions.

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“…Based largely on a series of papers indicating differentially greater deficits in context-dependent memory performance in patients with schizophrenia (Huron, Danion et al 1995;Rizzo, Danion et al 1996;Vinogradov, WillisShore et al 1997;Kazes, Berthet et al 1999), many would now argue for a specific source memory deficit in this population. The literature is far from uniform on this issue, however.…”

Section: Introductionmentioning

confidence: 99%

Distinguishing familiarity-based from source-based memory performance in patients with schizophrenia

Weiss

Goff

Duff

et al. 2008

Schizophrenia Research

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Background-There is substantial current interest in the cognitive deficits associated with schizophrenia, particularly those in the realm of memory. Yet the exact nature of these deficits remains a matter of some debate. This study sought to examine performance on two distinct aspects of memory performance: familiarity-based and source-based memory processes.Methods-Eighteen medicated outpatients with schizophrenia and eighteen healthy adult control subjects performed an external source memory task. Key measures included the ability to distinguish old (previously experienced) items from new items, the ability to correctly identify the source (male voice or female voice) of previously experienced items, and the reaction time associated with these responses.Results-Patients with schizophrenia showed an impaired ability to distinguish old from new items, but intact performance in correctly identifying the source of items recognized as old. Whereas control subjects showed a rapid response to items deemed unfamiliar, particularly in rejecting novel items, these responses were slowed in patients with schizophrenia. This was not attributable to a generalized diminution in processing speed, as reaction times to correctly recognized old items (regardless of source accuracy) did not differ between the two groups.Conclusions-Patients with schizophrenia demonstrated impaired familiarity-based and intact source-based memory performance. In addition, the reaction time for novelty detection, an important component of familiarity-based memory, was significantly delayed in patients compared to controls, while the response times for source-based decisions were completely overlapping. Considered together, these findings suggest a deficit in the familiarity-based aspect of episodic memory in at least some patients with schizophrenia.

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Patients with Schizophrenia Remember that an Event has Occurred, but not When

Cited by 97 publications

References 10 publications

Six-year course of bulimia nervosa

Six-year course of bulimia nervosa

Organization of Cognitive Control Within the Lateral Prefrontal Cortex in Schizophrenia

Distinguishing familiarity-based from source-based memory performance in patients with schizophrenia

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