Patients' Views of Surgery and Surveillance for Familial Adenomatous Polyposis

Fritzell, Kaisa; Persson, C. Ljungberg; Björk, Jan; Hultcrantz, Rolf; Wettergren, Lena

doi:10.1097/ncc.0b013e3181bb0cf1

Cited by 21 publications

(29 citation statements)

References 63 publications

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“…If FAP is not treated, it develops into colorectal cancer that occurs in 100% of cases by the age of 50 years (Greco, 2007;Razmus et al, 2008). Prophylactic surgery (removal of the entire large bowel) is recommended by the age of 18-20 years and regular gastroscopy is also recommended postoperatively to detect development of polyps in the duodenum (Fritzell, Persson, Bjork, Hultcrantz, & Wettergren, 2010). Those with a genetic predisposition to FAP are also at risk of developing cancers of the thyroid, small bowel, liver, pancreas, and brain (Greco, 2007).…”

Section: Familial Adenomatous Polyposismentioning

confidence: 99%

Working Toward an Understanding of the Impact of Hereditary Cancers

Framp¹

2010

Gastroenterology Nursing

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Hereditary diffuse gastric cancer is a genetically inherited aggressive form of stomach cancer. Once the person is diagnosed as having this gene, they have a 75%-80% chance of inheriting the cancer. People who are at risk of this genetic mutation have to meet many challenges relating to the implications of the disease. An understanding is required by nurses to guide them in the provision of care for those afflicted with this inherited form of gastric cancer. A review of literature has been undertaken relating to other genetically inherited cancers including hereditary nonpolyposis colon cancer, familial adenomatous polyposis, and hereditary lobular breast cancer. The findings from the literature assist nurses in understanding the physical and psychological implications of genetically inherited cancer; however, further study is required to gain a complete understanding of the implications of hereditary diffuse gastric cancer.

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Section: Familial Adenomatous Polyposismentioning

confidence: 99%

Working Toward an Understanding of the Impact of Hereditary Cancers

Framp¹

2010

Gastroenterology Nursing

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“…4,[6][7][8][9] To explore patients' views of what it is like to live with FAP, our research group conducted focus-group interviews among patients who had undergone prophylactic colorectal surgery. 5 The results showed that abdominal discomfort and pain were important reasons for concern in regard to living with FAP, including insecurity caused…”

Section: Introductionmentioning

confidence: 99%

“…Most patients also report a need for dietary restrictions 3,4 to avoid disturbing abdominal symptoms. 5 Symptoms have been suggested to be more prevalent in patients with an IPAA than in those with an IRA; 3 knowledge is limited regarding symptoms experienced by patients with an ileostomy. 6 As measured with standardized questionnaires, health status in patients with FAP after prophylactic colorectal surgery has been reported to be equivalent to population norms.…”

Section: Introductionmentioning

confidence: 99%

Self-Reported Abdominal Symptoms in Relation to Health Status in Adult Patients With Familial Adenomatous Polyposis

Fritzell

Björk²,

Hultcrantz³

et al. 2011

Diseases of the Colon &Amp; Rectum

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“…Here again there is a stark difference between BRCA and FAP. Without surgical intervention, mortality from gastrointestinal cancer for individuals with FAP is almost 100%, with half of patients dying before age 50 [4]. In contrast, individuals with a BRCA mutation who do not have prophylactic surgery can have a normal, or near normal, life expectancy [13].…”

Section: Genetic Penetrance and Mortalitymentioning

confidence: 99%

“…Most hereditary cancers have established prophylactic treatments that are routinely recommended by health care professionals. For example, the standard of care for individuals with gene alterations related to FAP is a prophylactic colectomy between 18 and 20 years old [4]. While there is a standard of care for BRCA positive women, it pertains only to their ovarian cancer risk: surveillance for ovarian cancer has proven ineffective [5], so the consensus is that oophorectomy should be offered to all women carrying a BRCA mutation between age 35-40 or once childbearing is complete [3].…”

Section: The Medical Factors No Standard Of Carementioning

confidence: 99%

BRCA Previvors: Medical and Social Factors That Differentiate Them From Previvors With Other Hereditary Cancers

Campo‐Engelstein

2018

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Droits d'auteur © Lisa Campo-Engelstein, 2017Ce document est protégé par la loi sur le droit d'auteur. L'utilisation des services d'Érudit (y compris la reproduction) est assujettie à sa politique d'utilisation que vous pouvez consulter en ligne.https://apropos.erudit.org/fr/usagers/politique-dutilisation/ Cet article est diffusé et préservé par Érudit.Érudit est un consortium interuniversitaire sans but lucratif composé de l'Université de Montréal, l'Université Laval et l'Université du Québec à Montréal. Il a pour mission la promotion et la valorisation de la recherche. In this paper, I outline some of the reasons why BRCA "previvors" (i.e., "survivors of a predisposition to cancer") are different from previvors with other hereditary cancers. I examine how the absence of a standard of care for breast cancer risk for women with a BRCA mutation, coupled with a broad range of genetic penetrance and lower mortality, makes BRCA different than other hereditary cancers that have clear and established guidelines. In addition to these medical differences, social factors like the cultural prominence of breast cancer and the social significance of breasts have engendered a more complicated individual previvor identity for and cultural response to women with a BRCA mutation. Mots clés Keywordsprevivor, BRCA, cancer héréditaire, cancer du sein previvor, BRCA, hereditary cancer, breast cancer Responsabilités des évaluateurs externes Peer-reviewer responsibilitiesLes évaluations des examinateurs externes sont prises en considération de façon sérieuse par les éditeurs et les auteurs dans la préparation des manuscrits pour publication. Toutefois, être nommé comme examinateur n'indique pas nécessairement l'approbation de ce manuscrit. Les éditeurs de BioéthiqueOnline assument la responsabilité entière de l'acceptation finale et la publication d'un article.Reviewer evaluations are given serious consideration by the editors and authors in the preparation of manuscripts for publication. Nonetheless, being named as a reviewer does not necessarily denote approval of a manuscript; the editors of BioéthiqueOnline take full responsibility for final acceptance and publication of an article.

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Patients' Views of Surgery and Surveillance for Familial Adenomatous Polyposis

Cited by 21 publications

References 63 publications

Working Toward an Understanding of the Impact of Hereditary Cancers

Working Toward an Understanding of the Impact of Hereditary Cancers

Self-Reported Abdominal Symptoms in Relation to Health Status in Adult Patients With Familial Adenomatous Polyposis

BRCA Previvors: Medical and Social Factors That Differentiate Them From Previvors With Other Hereditary Cancers

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