Patients’ reports of the factors influencing medication adherence in bipolar disorder – An integrative review of the literature

Crowe, Marie; Wilson, Lynere; Inder, Maree

doi:10.1016/j.ijnurstu.2011.03.008

Cited by 46 publications

(55 citation statements)

References 54 publications

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“…Brief psychoeducational interventions focusing specifically on medication adherence can be integrated into clinical practice 354. Flexible and collaborative engagement to address individual risk factors for non‐adherence is recommended to optimize acceptability of pharmacological therapies 353, 355, 356, 357…”

Section: Maintenance Therapy For Bipolar Disordermentioning

confidence: 99%

Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder

et al. 2018

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The Canadian Network for Mood and Anxiety Treatments (CANMAT) previously published treatment guidelines for bipolar disorder in 2005, along with international commentaries and subsequent updates in 2007, 2009, and 2013. The last two updates were published in collaboration with the International Society for Bipolar Disorders (ISBD). These 2018 CANMAT and ISBD Bipolar Treatment Guidelines represent the significant advances in the field since the last full edition was published in 2005, including updates to diagnosis and management as well as new research into pharmacological and psychological treatments. These advances have been translated into clear and easy to use recommendations for first, second, and third‐ line treatments, with consideration given to levels of evidence for efficacy, clinical support based on experience, and consensus ratings of safety, tolerability, and treatment‐emergent switch risk. New to these guidelines, hierarchical rankings were created for first and second‐ line treatments recommended for acute mania, acute depression, and maintenance treatment in bipolar I disorder. Created by considering the impact of each treatment across all phases of illness, this hierarchy will further assist clinicians in making evidence‐based treatment decisions. Lithium, quetiapine, divalproex, asenapine, aripiprazole, paliperidone, risperidone, and cariprazine alone or in combination are recommended as first‐line treatments for acute mania. First‐line options for bipolar I depression include quetiapine, lurasidone plus lithium or divalproex, lithium, lamotrigine, lurasidone, or adjunctive lamotrigine. While medications that have been shown to be effective for the acute phase should generally be continued for the maintenance phase in bipolar I disorder, there are some exceptions (such as with antidepressants); and available data suggest that lithium, quetiapine, divalproex, lamotrigine, asenapine, and aripiprazole monotherapy or combination treatments should be considered first‐line for those initiating or switching treatment during the maintenance phase. In addition to addressing issues in bipolar I disorder, these guidelines also provide an overview of, and recommendations for, clinical management of bipolar II disorder, as well as advice on specific populations, such as women at various stages of the reproductive cycle, children and adolescents, and older adults. There are also discussions on the impact of specific psychiatric and medical comorbidities such as substance use, anxiety, and metabolic disorders. Finally, an overview of issues related to safety and monitoring is provided. The CANMAT and ISBD groups hope that these guidelines become a valuable tool for practitioners across the globe.

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Section: Maintenance Therapy For Bipolar Disordermentioning

confidence: 99%

Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder

et al. 2018

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“…Non-adherence is explained by "lack of insight" or as a symptom of disease for patients with mental disorders, but these conditions give limited information about medication adherence (9). Major barriers to compliance in patients with mental disorders include age, gender, marital status, substance use, psychotic symptoms, personality disorders, lack of insight and knowledge, chronicity of disorder, poor social support, fear of stigmatization, the poor quality of information available about treatment, the complexity of medication regimens, concerns about side effects, lack of comprehension of treatment benefits, and poor communication or lack of trust between the patient and his or her clinician (10).…”

Section: Assessment Of Treatment Adherence In Patients With Bipolar Dmentioning

confidence: 99%

Assessment of Treatment Adherence in Patients with Bipolar Disorder

Karaytuğ¹,

Keskin²,

Tamam³

et al. 2017

JMOOD

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Objective: Non-adherence with medication is very common in patients with Bipolar Disorder (BD) and is the most frequent cause of recurrence. The aim of this study was to assess treatment adherence and related demographic and clinical factors in patients with bipolar disorder. Manual of Mental Disorders, fourth edition (DSM-IV) Axis II (SCID-II) was used to determine the comorbidity of personality disorders. Well, moderately, and poorly adherent patients were compared with respect to clinical and socio-demographic variables and functionality scores. Results:The rate of moderately and poorly adherent patients was 70.6% of the sample. Married patients and patients with social support were more adherent. The rate of previous suicide attempt was higher in well adherers. Comorbidity with personality disorders, alcohol and substance use, and the type of treatment were not associated with adherence. Conclusions:The results of this study have shown that being single and lacking social support were the factors that have the most significant effect on treatment adherence. Good adherers may have a better outcome, so patients with BD especially who do not have efficient social support should be monitored for treatment adherence closely.

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“…B ipolar disorder causes great harms in people's lives, because it leads to suicidal attempt, substance abuse, and high rate of hospitalization, poor academic success, interpersonal communication and legal problems (1)(2)(3). World Health Organization has defined bipolar disorder in diseases which cause severe disability (4).…”

Section: Introductionmentioning

confidence: 99%

“…Drug incompliance rates vary from 20% to 60% in bipolar patients (2,3,(17)(18)(19)(20). Drug incompliance causes patients diagnosed with bipolar disorder to have lower life quality (2,3), increased hospitalization rate, increased expenses of care and high mortality (2,20,21), depressive attacks, suicide, functional deterioration in addition to treatment disorders and signs (22). Studies related to factors affecting drug compliance and incompliance are quite limited in patients with bipolar disorder.…”

Section: Introductionmentioning

confidence: 99%

Relationship between drug compliance, coping with stress, and social support in patients with bipolar disorder

Aksoy¹,

Kelleci²

2016

Dusunen Adam

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Relationship between drug compliance, coping with stress, and social support in patients with bipolar disorder Objective: In bipolar disorder, recurrence rate is relatively high. With each episode, the risk of a new episode is increased. The first choice is drug treatment. However, patients have serious difficulties in drug compliance. This study was conducted to investigate drug compliance of patients with bipolar disorder, and to determine relationships between drug compliance, coping with stress, and social support. Method: The target population of the study included 280 patients registered in a state hospital with the diagnosis of bipolar disorder in 2011, residing in the city center, and having no other psychiatric disorders. Of these 280 patients, 150 who agreed to participate in the study and accepted to be visited at home after they were telephoned comprised the study sample. Of the patients in the target population, phone numbers and addresses were changed in 112 patients, and 18 refused to have a home-visit, so they were excluded from the study. Data were collected using the personal information form, Morisky Medication Adherence Scale, Multidimensional Scale of Perceived Social Support and Ways of Coping Scale. Results: In this study, it was determined that 55.3% of the patients did not comply with drug treatment. The patients with poor drug compliance preferred mainly desperate approach and submissive approach subdimensions of the Ways of Coping Scale more. There was no difference between patients with and without drug compliances in terms of social support. Conclusions: It is considered that development of effective coping strategies would promote drug compliance in patients with bipolar disorder. Keywords: Bipolar disorder, coping, medication compliance, nursing, social support ÖZET Bipolar hastalarda ilaç uyumunun stresle başetme ve sosyal destekle ilişkisi Amaç: Bipolar bozukluğun tekrarlama oranı oldukça yüksektir. Geçirilen her atak yeni bir atak geçirme riskini arttırır. Tedavide ilk seçenek ilaç tedavisidir. Ancak hastaların ilaç tedavisine uyumla ilgili ciddi sorunları bulunmaktadır. Bu çalışma bipolar hastaların ilaç uyumunu belirlemek, stresle başetme ve sosyal destekle ilişkisini incelemek amacı ile yapılmıştır. Yöntem: Araştırmanın evrenini bir devlet hastanesine 2011 yılında bipolar bozukluk tanısı ile kayıtlı olan, il merkezinde yaşayan, ek psikiyatrik tanısı olmayan 280 hasta, örneklemi ise telefonla aranarak araştırmaya katılmayı ve ev ziyaretini kabul eden 150 hasta oluşturdu. Evreni oluşturan hastalardan 112 kişiye telefon ve adres değişikliği, 18 kişiye ise ev ziyaretini kabul etmeme nedeni ile ulaşılamamıştır. Veriler, "Kişisel Bilgi Formu", "Morisky Uyum Ölçeği", "Çok Boyutlu Algılanan Sosyal Destek Ölçeği" ve "Stresle Başa Çıkma Tarzları Ölçeği" ile toplandı. İlaç uyumu iyi olan ve ilaç uyumu olmayan hastalar stresle baş etme biçimleri ve sosyal destek puanları açısından karşılaştırıldı. Bulgular: Çalışmada hastaların %55.3'ünün ilaç tedavisine uyumsuz olduğu belirlendi...

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Patients’ reports of the factors influencing medication adherence in bipolar disorder – An integrative review of the literature

Cited by 46 publications

References 54 publications

Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder

Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder

Assessment of Treatment Adherence in Patients with Bipolar Disorder

Relationship between drug compliance, coping with stress, and social support in patients with bipolar disorder

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