Assessment of Treatment Adherence in Patients with Bipolar Disorder

Karaytuğ, Mahmut Onur; Keskin, Necla; Tamam, Lut; Özpoyraz, Nurgül; Demirkol, Mehmet Emin; Gürbüz, Mahmut

doi:10.5455/jmood.20170613090644

Cited by 3 publications

(6 citation statements)

References 17 publications

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“…In a similar study done by Hayanes et al ., 2008[ 28 ] Karaytug et al . [ 1 ] that race, ethnicity, gender, education, occupation, and income do not have significant effect on adherence.…”

Section: Discussionmentioning

confidence: 99%

“…Bipolar affective disorder (BPAD) is a chronic, disabling psychiatric disorder which can cause significant morbidity and mortality. [ 1 ] It is an episodic illness with fluctuating level of severity of manic and depressive symptoms with euthymic period. [ 2 ] The current prevalence of BPAD is 0.4%–0.5%.…”

Section: Introductionmentioning

confidence: 99%

“…[ 2 ] The first-line treatment for BPAD is pharmacotherapy whereas a combination of medications with psychotherapies has proven to lead to relatively normal and productive life in 60%–80% patients. [ 1 ] The efficacy of medications is directly related with adherence. [ 1 ] The WHO has defined treatment adherence as “The extent to which a person's behavior taking medication, following a diet, and or executing lifestyle changes, corresponds with agreed recommendations from a health care provider.”[ 3 ] The existing literature suggests about 41% of patients were believed to be nonadherent to medication, ranging from 20% to 60%.…”

Section: Introductionmentioning

confidence: 99%

“…[ 1 ] The efficacy of medications is directly related with adherence. [ 1 ] The WHO has defined treatment adherence as “The extent to which a person's behavior taking medication, following a diet, and or executing lifestyle changes, corresponds with agreed recommendations from a health care provider.”[ 3 ] The existing literature suggests about 41% of patients were believed to be nonadherent to medication, ranging from 20% to 60%. [ 4 5 ] In an Indian study, patient-related factors contributed for 33.5%, drug-related factors for 32% and disease-related factors for 31% of nonadherence.…”

Section: Introductionmentioning

confidence: 99%

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Nonadherence in bipolar disorder patients: A 14-year retrospective study

Narayanan

Jith

Bansal

2020

Indian J Psychiatry

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Background: Bipolar disorder is a disabling psychiatric disorder. The existing literature suggests about 41% of patients to be nonadherent. Nonadherence leads to relapses, delay in recovery besides higher inpatient care cost as well as higher global cost of the disease. Nonadherence in bipolar affective disorder (BPAD) is a complex phenomenon, its critical determinants are yet to be identified with certainty. Aims: This study aims to assess the prevalence of nonadherence in BPAD and to delineate the factors associated with it. Methods: Medical records were reviewed in this study from 2005 to 2019 at a medical college in Kerala. Patients who were diagnosed with BPAD according to International Classification of Diseases 10 and who were needing or opting for prophylaxis were included. Patients who were not taking medications for at least 1 week were termed as nonadherent. We included 150 participants in our study. Results: To test the statistical significance of the association of categorical variables between H/O of adherence and nonadherence, Chi-square test was used. In the sample, 82.7% had at least 1 week of history of noncompliance in the past. The most common reason was poor understanding of illness by the family (56%) followed by a negative aspect of the patient toward the drug (20%). Conclusion: Therefore, this study concludes that though majority of the patients have a history of nonadherence of at least 1 week on long-term follow-up, it was seen that majority of the patients were more than 80% adherent to medications.

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“…In a similar study done by Hayanes et al ., 2008[ 28 ] Karaytug et al . [ 1 ] that race, ethnicity, gender, education, occupation, and income do not have significant effect on adherence.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Nonadherence in bipolar disorder patients: A 14-year retrospective study

Narayanan

Jith

Bansal

2020

Indian J Psychiatry

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“…Rahatsızlığın ehemmiyetini kabul etmek istemezler. Yan etkilerden ziyade bu yan etkilerin ortaya çıkacak olmasına dair endişenin uyumsuzluğu ortaya çıkarabileceğini ifade eden araştırmacılar da bulunmaktadır 31 .…”

Section: Tedaviye Uyumsuzluk Nedenleriunclassified

Bipolar Bozukluk Tanılı Hastalarda Tedaviye Uyum ve İlişkili Faktörler

Karaytuğ

Tamam

Demirkol

et al. 2022

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Despite the current treatment options, there is no significant increase in the treatment compliance of patients with bipolar disorder. In those with chronic disease, adherence to treatment is an important factor affecting recovery. Nonadherence to treatment is generally explained by "lack of insight" in psychiatric disorders. Adherence to treatment also affects the way the patient's family and himself perceive the disease. Medication compliance is adversely affected by patients with insufficient social support, lack of knowledge about the disorder, dysfunctional attitudes in their families, and fear of stigma. Three main items related to non-compliance with drug therapy were identified in the studies. Patient-related factors; age, gender, marital status, substance use, psychotic disorder, personality disorder, earnings related to patient role, factors related to illness; insufficient insight, insufficient information on long-term drug use, the disease becoming chronic, lack of information about the disease, stigma, disease acceptance/rejection, drug-related factors; improvement or no signs of improvement, side effects, and concerns about drug addiction. Among these substances, the most known are drug-related side effects. In individuals with bipolar disorder, drug non-compliance decreases the quality of life and increases the rate of hospitalization. It also causes high care costs and mortality, depressive episodes and suicides. Identifying and eliminatingthe factors that cause treatment non-compliance will increase treatment compliance and reduce treatment costs and the number of hospitalizations.

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The effect of mindfulness on medication adherence in individuals diagnosed with Schizophrenia: A cross‐sectional study

Üşenmez

Gültekin

Erkan

et al. 2022

Perspect Psychiatric Care

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Objective: The aim of this study is to determine the effect of mindfulness on medication adherence in individuals diagnosed with schizophrenia. Materials and Methods:This cross-sectional study was conducted with 147 individuals diagnosed with schizophrenia. The data were collected using the Descriptive Characteristics Form, Morisky Medication Adherence Scale, and Mindful Attention Awareness Scale.Results: A strong positive correlation was determined between the mindfulness level and medication adherence of the individuals diagnosed with schizophrenia. Furthermore, mindfulness of the individuals diagnosed with schizophrenia was statistically significant in explaining medication adherence (p < 0.05) and mindfulness predicted medication adherence by 64%. Conclusion:It was observed that the individuals' mindfulness level was low and half of the participants had low medication adherence. Moreover, as their mindfulness level increased, so did their medication adherence.

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Assessment of Treatment Adherence in Patients with Bipolar Disorder

Cited by 3 publications

References 17 publications

Nonadherence in bipolar disorder patients: A 14-year retrospective study

Nonadherence in bipolar disorder patients: A 14-year retrospective study

Bipolar Bozukluk Tanılı Hastalarda Tedaviye Uyum ve İlişkili Faktörler

The effect of mindfulness on medication adherence in individuals diagnosed with Schizophrenia: A cross‐sectional study

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