Patients’ perspective of pruritus in chronic plaque psoriasis: a questionnaire‐based study

Amatya, Beni; Wennersten, G; Nordlind, Klas

doi:10.1111/j.1468-3083.2008.02591.x

Cited by 133 publications

(204 citation statements)

References 20 publications

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“…The subjective descriptions of experimentally induced pruritus reported by the participants in this study were similar to those of previous studies [28,29] . The perception of pruritus might vary from one individual to another, especially according to gender [28] .…”

Section: Discussionsupporting

confidence: 78%

“…The perception of pruritus might vary from one individual to another, especially according to gender [28] . However, we did not find any gender difference in the perception of clinical or experimentally induced pruritus in the psoriasis patients of the present study.…”

Section: Discussionmentioning

confidence: 99%

“…This could be the reason why antihistamines are less effective for the treatment of pruritus in psoriasis [26][27][28] .…”

Section: Discussionmentioning

confidence: 99%

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Responses to Intradermal Injections of Substance P in Psoriasis Patients with Pruritus

Amatya

Nordlind²,

Wahlgren³

2009

Skin Pharmacol Physiol

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Background: Various mediators have been suggested for the pathogenesis of pruritus in psoriasis. Methods: To investigate cutaneous responses of substance P in pruritic lesional and nonlesional areas of psoriasis patients and in healthy controls, substance P, saline and histamine were injected intradermally. After each injection, pruritus, flare and wheal were recorded. Results: There was no statistical difference in the latency period, duration, area under the curve and maximum intensity of pruritus evoked by substance P (10^–5 and 10^–6 mol/l) between psoriasis and healthy control skin. Substance P (10^–5 mol/l) induced a tendency to a greater intensity of pruritus in lesional compared to nonlesional psoriatic skin (p = 0.08). Histamine produced a shorter itch latency period (p < 0.05) and a lower maximum intensity of pruritus (p = 0.05) in lesional psoriasis skin than in healthy control skin. No significant difference in flare area was observed between the psoriasis patients and healthy controls. The histamine-induced wheal was smaller in psoriasis patients than in healthy individuals (p < 0.05). Conclusion: Intradermally injected substance P induced pruritus, flare and wheal in psoriasis patients. However, these responses did not differ significantly from those of the healthy controls.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

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Responses to Intradermal Injections of Substance P in Psoriasis Patients with Pruritus

Amatya

Nordlind²,

Wahlgren³

2009

Skin Pharmacol Physiol

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“…Pruritus is an important predictor of psychosocial morbidity and decreased QOL in numerous disorders, including general skin disorders (10,11), psoriasis (12,13), atopic dermatitis (14,15), uremia (16 -18), and idiopathic pruritus (19,20). Across conditions, sleep disruption is commonly reported among patients with pruritus, including both difficulties falling asleep and waking up multiple times during the night (13,15,16).…”

Section: Introductionmentioning

confidence: 99%

“…Across conditions, sleep disruption is commonly reported among patients with pruritus, including both difficulties falling asleep and waking up multiple times during the night (13,15,16). Pruritus is also associated with agitation, poor concentration, and symptoms of anxiety and depression (10,12,(21)(22)(23)(24). To our knowledge, no studies have investigated the degree to which pruritus may affect physical and mental health and disability in SSc.…”

Section: Introductionmentioning

confidence: 99%

Association of pruritus with quality of life and disability in systemic sclerosis

El‐Baalbaki¹,

Razykov²,

Hudson³

et al. 2010

Arthritis Care & Research

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Objective. To our knowledge, no studies have investigated the association of pruritus, which is present in almost half of patients with systemic sclerosis (SSc; scleroderma), with quality of life (QOL) and disability. The objective of this study was to investigate the association of pruritus with QOL and disability in SSc. Methods. We performed a cross-sectional, multicenter study of 578 SSc patients >1 year post-enrollment in the Canadian Scleroderma Research Group Registry. Patients reported whether they experienced pruritus during the past month on most days and underwent clinical histories and medical examinations. QOL was measured using the mental and physical component summary scores of the Short Form 36, and disability was measured with the Health Assessment Questionnaire disability index. The association of pruritus with QOL and disability was estimated using linear regression, controlling for sociodemographic and disease variables. Results. A total of 248 patients (43%) reported pruritus on most days. Patients with pruritus had significantly worse mental (Hedges's g ‫؍‬ ؊0.43; 95% confidence interval [95% CI] ؊0.59, ؊0.26) and physical function (Hedges's g ‫؍‬ ؊0.51; 95% CI ؊0.68, ؊0.34) and greater disability (Hedges's g ‫؍‬ 0.46; 95% CI 0.29, 0.63) than patients without pruritus. In multivariate analyses, controlling for age, sex, marital status, education, disease duration, skin score, number of tender joints, gastrointestinal symptoms, breathing problems, Raynaud's phenomenon, and finger ulcers, pruritus was independently associated with mental (P ‫؍‬ 0.017) and physical function (P ‫؍‬ 0.003), but not disability (P ‫؍‬ 0.112). Conclusion. Pruritus is common and associated with QOL in SSc. More attention to pruritus in SSc is needed, including its measurement, etiology, trajectory, and potential methods for intervention.

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Itch

Reszke¹,

Szepietowski²

2019

Advances in Integrative Dermatology

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Patients’ perspective of pruritus in chronic plaque psoriasis: a questionnaire‐based study

Abstract: Pruritus is a common symptom in patients with chronic plaque psoriasis.

Cited by 133 publications

References 20 publications

Responses to Intradermal Injections of Substance P in Psoriasis Patients with Pruritus

Responses to Intradermal Injections of Substance P in Psoriasis Patients with Pruritus

Association of pruritus with quality of life and disability in systemic sclerosis

Itch

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