Patients Nutritional Status: BMI and serum albumin as a predictive indicator of survival in patients with metastatic breast cancer

Courtney, D.; Moloney, Brian; Lowery, Aoife; Kerin, M J

doi:10.1016/j.ejso.2017.01.120

Cited by 2 publications

(2 citation statements)

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“…A study by Lai et al conducted on a group of 228 elderly people showed that the concomitant presence of low albumin and BMI in the elderly was associated with a poor prognosis for many diseases [58]. These findings have also been confirmed in other studies [59][60][61][62][63]. It has been shown that low albumin levels and/or low BMI values are associated with higher mortality rates and a worse prognosis in hemodialyzed and oncological patients.…”

Section: Discussionmentioning

confidence: 67%

Evaluation of Albumin, Transferrin and Transthyretin in Inflammatory Bowel Disease Patients as Disease Activity and Nutritional Status Biomarkers

et al. 2023

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Inflammatory bowel disease (IBD), which includes Crohn’s disease (CD) and ulcerative colitis (UC), is often accompanied by malnutrition that manifests itself as nutrient deficiencies and body mass loss or deficit. The purpose of this study is to evaluate the utility of albumin, transferrin and transthyretin levels in the assessment of nutritional status and IBD activity. The case–control study included 82 IBD patients. The serum concentrations of albumin, transferrin and transthyretine were determined by a quantitative sandwich enzyme-linked immunosorbent assay (ELISA). Significantly lower median concentrations of albumin were found in the IBD patients vs. controls and in CD patients compared to the UC patients. Significantly higher median transthyretin concentrations were found in the IBD patients compared to the healthy subjects. There were no significant differences in median transferrin concentrations between the IBD patients and the healthy subjects. Significantly higher albumin levels were found in IBD patients in remission compared to patients with moderate and severe exacerbation of IBD symptoms. There were no significant differences in the median transferrin or transthyretin levels in patients with IBD depending on disease activity. No differences were identified in the median transferrin or transthyretin levels in the IBD patients according to nutritional status. The median albumin concentrations in the IBD subjects were significantly higher in patients with normal body fat, normal BMI and normal waist circumferences compared to those with an abnormal nutritional status. The albumin levels reflect both nutritional status and disease activity and therefore cannot be considered a prognostic marker of malnutrition in IBD. As regards the utility of transferrin and transthyretin as markers of activity and nutritional status in IBD patients, further studies are required.

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Section: Discussionmentioning

confidence: 67%

Evaluation of Albumin, Transferrin and Transthyretin in Inflammatory Bowel Disease Patients as Disease Activity and Nutritional Status Biomarkers

et al. 2023

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“…Combined low albumin levels and BMIs in the elderly associate with poor prognoses in several diseases [10,[34][35][36][37]. Mechanisms to explain lower serum albumin [35,38] and BMI [39] may involve chronic inflammation, which appears to be a common factor in various diseases affecting the elderly, including cancer, cardiovascular disease, diabetes, cognitive impairment, frailty, sarcopenia [40,41].…”

Section: Albumin and Bmimentioning

confidence: 99%

Body mass index and albumin levels are prognostic factors for long-term survival in elders with limited performance status

Lai

Liu

et al. 2020

Aging

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Elderly long-term care facility residents typically have musculoskeletal conditions that may lead to long-term disability and increased mortality. Our main objective was to explore the relationship between body mass index (BMI), albumin levels, and mortality in elderly individuals with limited performance status. Among 182 participants (mean age, 78.8 years; 57% women), 11%, 64%, and 25% had serum albumin levels of <2.8, 2.8-3.5, and >3.5 g/dL, respectively. After multivariate adjustments, diastolic blood pressure >90 mmHg was associated with all-cause mortality [hazard ratio (HR) = 2.08, 95% confidence interval (CI) = 1.13-3.82; P = 0.018]. In addition, BMI <18.5 kg/m2 and albumin level <2.8 g/dL associated with higher mortality than BMI = 18.5-24 kg/m2 and albumin level > 3.5 g/dL (HR = 1.80, 95% CI = 1.11-2.94 and HR = 2.54, 95% CI 1.22-5.30, respectively; P = 0.018 and 0.013, respectively). Highest mortality was noted in participants with albumin levels <2.8 g/dL and BMIs <18.5 kg/m2 (HR = 6.12, 95% CI = 1.85-20.21, P = 0.003). Combined hypoalbuminemia (albumin level < 2.8 g/dL) and low BMI (<18.5 kg/m2) may be a useful prognostic indicator of high mortality risk in elderly individuals with limited performance status.

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Patients Nutritional Status: BMI and serum albumin as a predictive indicator of survival in patients with metastatic breast cancer

Cited by 2 publications

References 0 publications

Evaluation of Albumin, Transferrin and Transthyretin in Inflammatory Bowel Disease Patients as Disease Activity and Nutritional Status Biomarkers

Evaluation of Albumin, Transferrin and Transthyretin in Inflammatory Bowel Disease Patients as Disease Activity and Nutritional Status Biomarkers

Body mass index and albumin levels are prognostic factors for long-term survival in elders with limited performance status

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