Body mass index and albumin levels are prognostic factors for long-term survival in elders with limited performance status

Lai, Kuan Yu; Wu, Tai-Hsien; Liu, Chiu Shong; Lin, Chi-Yi; Lin, Cheng Chieh; Lai, Ming May

doi:10.18632/aging.102642

Cited by 20 publications

(17 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Combined hypoalbuminemia and low BMI has been shown to be a powerful prognostic indicator of high mortality risk in older individuals with limited performance status. 3,30 In addition, hypoalbuminemia predicts outcome of COVID-19 independantly of age and comorbidity. 31 Oxygen therapy was required more often in our series than in large series of younger adult subjects, all form of diseases confounded, probably to be attributed to the severity of disease in regard to age and comorbidities.…”

Section: Discussionmentioning

confidence: 99%

COVID‐19 in Older Adults: A Series of 76 Patients Aged 85 Years and Older with COVID‐19

Vrillon

Hourrègue

Azuar

et al. 2020

J American Geriatrics Society

View full text Add to dashboard Cite

BACKGROUND Clinical presentation and risk factors of death in COVID‐19 in oldest adults have not been well characterized. OBJECTIVES To describe clinical features and outcome of COVID‐19 in patients older than 85 years and study risk factors for mortality. DESIGN Prospective cohort. PARTICIPANTS AND SETTING Patients aged 85 years and older, admitted in noncritical care units at the University Hospital Lariboisière Fernand‐Widal (Paris, France) for confirmed severe acute respiratory syndrome coronavirus 2 infection were included and followed up for 21 days. MEASUREMENTS Clinical and laboratory findings were collected. Cox survival analysis was performed to explore factors associated with death. RESULTS From March 14 to April 11, 2020, 76 patients (median age = 90 (86–92) years; women = 55.3%) were admitted for confirmed COVID‐19. Of the patients, 64.5% presented with three or more comorbidities. Most common symptoms were asthenia (76.3%), fever (75.0%) and confusion and delirium (71.1%). An initial fall was reported in 25.0% of cases, and digestive symptoms were reported in 22.4% of cases. COVID‐19 was severe in 51.3% of cases, moderate in 32.9%, and mild in 15.8%. Complications included acute respiratory syndrome (28.9%), cardiac decompensation (14.5%), and hypotensive shock (9.0%). Fatality at 21 days was 28.9%, after a median course of disease of 13 (8–17) days. Males were overrepresented in nonsurvivors (68.2%). In survivors, median length of stay was 12 (9–19.5) days. Independent predictive factors of death were C‐reactive protein level at admission and lymphocyte count at nadir. CONCLUSION Specific clinical features, multiorgan injury, and high case fatality rate are observed in older adults with COVID‐19. However, rapid diagnosis, appropriate care, and monitoring seem to improve prognosis.

show abstract

Section: Discussionmentioning

confidence: 99%

COVID‐19 in Older Adults: A Series of 76 Patients Aged 85 Years and Older with COVID‐19

Vrillon

Hourrègue

Azuar

et al. 2020

J American Geriatrics Society

View full text Add to dashboard Cite

show abstract

“…The registered dietitians obtained the residents’ age, sex, and body mass index (BMI) from the nursing care records. The BMI was categorized as follows: 0, ≥18.5 kg/m 2 ; 1, <18.5 kg/m 2 [ 11 ].…”

Section: Methodsmentioning

confidence: 99%

Observational Variables for Considering a Switch from a Normal to a Dysphagia Diet among Older Adults Requiring Long-Term Care: A One-Year Multicenter Longitudinal Study

Takeda

Watanabe

Matsushita

et al. 2022

IJERPH

View full text Add to dashboard Cite

This one-year multicenter longitudinal study aimed to assess whether older adult residents of long-term care facilities should switch from a normal to a dysphagia diet. Using the results of our previous cross-sectional study as baseline, older adults were subdivided into those who maintained a normal diet and those who switched to a dysphagia diet. The explanatory variables were age, sex, body mass index (BMI), Barthel Index, clinical dementia rating (CDR), and 13 simple and 5 objective oral assessments (remaining teeth, functional teeth, oral diadochokinesis, modified water swallowing test, and repetitive saliva swallowing test), which were used in binomial logistic regression analysis. Between-group comparison showed a significantly different BMI, Barthel Index, and CDR. Significant differences were also observed in simple assessments for language, drooling, tongue movement, perioral muscle function, and rinsing and in objective assessments. In multi-level analysis, switching from a normal to a dysphagia diet was significantly associated with simple assessments of tongue movement, perioral muscle function, and rinsing and with the objective assessment of the number of functional teeth. The results suggest that simple assessments can be performed regularly to screen for early signs of discrepancies between food form and eating/swallowing functions, which could lead to the provision of more appropriate food forms.

show abstract

“…Historically, there have been reports about the association between hypoalbuminemia and poor prognosis 22 – 25 . Although the underlying mechanism is not clear, it has been reported that albumin levels decline in older age, and age-related visceral protein loss and/or worsening nutritional status are thought to be the factors behind hypoalbuminemia 25 – 28 . These factors might also contribute to low albumin levels and poor prognosis in elderly patients with newly diagnosed AML in our cohort.…”

Section: Discussionmentioning

confidence: 99%

High CRP-albumin ratio predicts poor prognosis in transplant ineligible elderly patients with newly diagnosed acute myeloid leukemia

Senjo

Onozawa

Hidaka

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Acute myeloid leukemia (AML) patients older than 65 years have a poor prognosis. Recently, CAR (C-reactive-protein/albumin ratio) has been actively reported as a prognostic index reflecting the nutritional and inflammatory status of elderly patients with solid tumors, but the usefulness of this index as a prognostic indicator in transplant-ineligible elderly AML patients has not been investigated. We studied genetic alterations and CARs in 188 newly diagnosed AML patients aged 65 years or older who were treated in a multicenter setting and had treated without HSCT. Both NCCN 2017 risk group, reflecting the genetic component of the tumor, and CAR, reflecting the inflammatory and nutritional status of the patient, successfully stratified the overall survival (OS) of the patients (2-year OS; CAR low vs high, 42.3% vs 17.8%, P < 0.001). Furthermore, in multivariate analysis, NCCN 2017 poor group and high CAR were extracted as independent poor prognostic factors predicting 2-year OS in the current study. We found, for the first time, that CAR at diagnosis predicted the prognosis of elderly patients with newly diagnosed AML treated without HSCT.

show abstract

Body mass index and albumin levels are prognostic factors for long-term survival in elders with limited performance status

Cited by 20 publications

References 50 publications

COVID‐19 in Older Adults: A Series of 76 Patients Aged 85 Years and Older with COVID‐19

COVID‐19 in Older Adults: A Series of 76 Patients Aged 85 Years and Older with COVID‐19

Observational Variables for Considering a Switch from a Normal to a Dysphagia Diet among Older Adults Requiring Long-Term Care: A One-Year Multicenter Longitudinal Study

High CRP-albumin ratio predicts poor prognosis in transplant ineligible elderly patients with newly diagnosed acute myeloid leukemia

Contact Info

Product

Resources

About