2019
DOI: 10.3329/bjms.v18i4.42909
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Patients’ Knowledge on Rheumatoid Arthritis presenting with Arthralgia in a Tertiary Care Teaching Hospital, Pakistan

Abstract: Objectives: The main aim of this study was to determine the level of knowledge about rheumatoid arthritis disease among patients presenting with arthralgia in a tertiary care teaching hospital, Pakistan. Materials and Methods: A cross-sectional study during the period of September 2015 - March 2016 in the Medical Out-Patient Department, Shaheed Mohtarma Benzir Bhutto Medical University Hospital, a tertiary care teaching hospital in Larkana, Pakistan. Patients above 40 years of age of either gender were i… Show more

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Cited by 3 publications
(3 citation statements)
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References 25 publications
(31 reference statements)
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“…4 However, joint pain involving multiple sites, persistent or recurrent, and severe may suggest other diagnoses. 4,5 Gouty arthritis is one of the rheumatological cause for joint pain. It is a rare diagnosis in children, thus complicating and delaying its' diagnosis as demonstrated in this 16-year-old teenage boy.…”
Section: Discussionmentioning
confidence: 99%
“…4 However, joint pain involving multiple sites, persistent or recurrent, and severe may suggest other diagnoses. 4,5 Gouty arthritis is one of the rheumatological cause for joint pain. It is a rare diagnosis in children, thus complicating and delaying its' diagnosis as demonstrated in this 16-year-old teenage boy.…”
Section: Discussionmentioning
confidence: 99%
“…This cytokine demonstrates its biological activity by interacting with specific receptors expressed on fibroblasts, neutrophil leukocytes, keratinocytes, endotheliosytes, and others.The binding of TNFα to these receptors activates such transcription factors as NF-kB, JNK, and AP-1, directly regulating the activity of the genes responsible for the biosynthesis of inflammatory mediators, primarily cytokines, and inducing cell apoptosis, i.e., their programmed death. 18,21,22 Over the past few decades, the concept of RA therapy has changed slightly.Induction of persistent remissions is the primary goal of treatment, and the basic anti-inflammatory drug used to achieve this goal is methotrexate (MT). 23 Moreover,an intense MT therapy should begin as soon as possible after the disease onset (best in the first 3 months) witha rapid escalation of the drug dose (up to 20-25 mg/ week).…”
Section: Introductionmentioning
confidence: 99%
“…The current objective of RA treatment is to suppress inflammation, pain, and prevent bone destruction. While the symptoms of RA are similar to those of other types of arthritis, such as Rheumatic Fever, Arthralgia, gouty arthritis, and they all have a high rate of morbidity and disability, it is important to distinguish between them 2,3,4 .Both doctors and patients are misled about the disparities in diagnostic capabilities and treatment options available to them 5 . It is critical to comprehend the disease at the molecular level, specifically at the amino acid level, in order to provide correct diagnosis and therapy options.…”
Section: Introductionmentioning
confidence: 99%